Application of Modeling to Scale-Up Dissolution in Pharmaceutical Manufacturing
This article attempts to provide a model-based approach to scale-up dissolution process from a 2 l lab-scale vessel to a 4,000 l scale vessel used in manufacturing.

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Continuous Preparation of Carbon-Nanotube-Supported Platinum Catalysts in a Flow Reactor Directly Heated by Electric Current
Researchers from Clausthal University of Technology present a continuous process for the production of highly active Pt catalysts supported by carbon nanotubes by use of an electrically heated tubular reactor.

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Multistep Flow Synthesis of Vinyl Azides and their use in the Copper-Catalyzed Huisgen-type Cycloaddition under Inductive-Heating Conditions
In this article, researchers from Leibniz University Hannover report the multistep flow synthesis of vinyl azides and their application in the synthesis of vinyltriazoles.

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Efficient and Selective Chemical Transformations under Flow Conditions: The Combination of Supported Catalysts and Supercritical Fluids
This paper reviews the current trends in the combined use of supported catalytic systems, either on solid supports or in liquid phases and supercritical fluids.

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The Eschenmoser Coupling Reaction under Continuous-Flow Conditions
In this paper, researchers from Technische Universität Ilmenau investigate the reaction kinetics of the Eschenmoser coupling reaction.

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Scaling up of Continuous-Flow, Microwave-Assisted, Organic Reactions by Varying the Size of Pd-Functionalized Catalytic Monoliths
Changing the volumetric capacity of the monolith under optimal reaction conditions was shown to increase the quantity of product from 31 mg per hour to 340 mg per hour.

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Evaluation of a Commercial Packed Bed Flow Hydrogenator for Reaction Screening, Optimization and Synthesis
Scientists from Amgen have evaluated the performance of the ThalesNano H-Cube(®)in the context of small scale reaction screening and optimization.

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Homocoupling of Aryl Halides in Flow: Space Integration of Lithiation and FeCl3 Promoted Homocoupling
Integration of the generation of aryllithiums by halogen–lithium exchange and FeCl3 promoted homocoupling has been effectively accomplished in an integrated flow microreactor system.

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Continuous Flow Photolysis of Aryl Azides: Preparation of 3H-Azepinones
This article describes the development of a continuous flow variant for the preparation of 7-membered nitrogen-containing heterocycles and demonstrates how the reaction can be further optimized using a flow system.

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Continuous Flow Hydrogenation using Polysilane-Supported Palladium/Alumina Hybrid Catalysts
Researchers from The University of Tokyo have developed continuous flow systems for hydrogenation using polysilane-supported palladium/alumina (Pd/(PSi-Al(2)O(3))) hybrid catalysts.

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Brenntag Opens New Head Office in India
New office represents Brenntag’s continued commitment to invest in India.

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SCM to Deliver Vial Filling Project
BrePco selects CDMO to initially produce clinical batches for eight clinical trial sites.

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INTERPHEX Unveils Conference Programming For May 2012 Event
This year’s conference and technical sessions will mark a new level of content, including new session criteria and formats, growth in the number of senior-level speakers, and a third day of programming.

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Pragmatic’s Imprinted Logic Moving into Commercial Production
Collaborative model to support scale-up across entire value chain.

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Dr Wilfried Hoffmann Joins Scale-up Systems
Following 28 years with Pfizer, Dr Wilfried Hoffmann joins Scale-up Systems Limited as a Principal Consultant.

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ELA’s Life Science Awards Take Centre Stage for a Second Year
Select Biosciences announce that the second annual Life Science Awards ceremony will be held on the evening of 29th May at the Radisson Blu hotel, Hamburg, Germany.

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UK Chemical Industry Under Threat
Experts have warned the UK’s chemical industry could be at risk following the announcement in May by Energy and Climate Change Secretary Chris Huhne of the fourth carbon budget plan.

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R3Fusion Names Mark Beemer as President of Ethanol
As President of the company’s Ethanol Division Mark Beemer will be responsible for the development, deployment and execution of the ethanol water separation business for North America.

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EU Commission Appoints First Ever Chief Scientific Adviser
The European commission has appointed Anne Glover as its first ever chief scientific adviser.

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DuPont Affirms Strong Long-Term Growth Outlook
CEO Ellen Kullman and the company’s senior leaders detail the dynamic global growth strategy for continuing to deliver strong, sustainable results in 2012 and beyond.

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"Some Like it Hot" - Continuous Flow Chemistry at High Temperatures and Pressures
University of Graz

More and more recently published chemistry examples in glass-chip- and Teflon based microreactors begin to exploit the possibility of superheating solvents for process intensification leading to drastically shortened reaction times.

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Quality Standards for 14C API for use in human clinical studies
Quotient Bioresearch

The Good Manufacturing Practice (GMP) state that the active pharmaceutical ingredient (API) intended for use in early stage clinical trials should be of "suitable" quality. The Clinic Ready quality standard ensures that the API is synthesised with all the appropriate documentation to facilitate QP release of the final IMP for guman clinical dosing.

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Microwave chemistry in SiC Reaction Vials
University of Graz

Using novel SiC-technology to mimic conventional heated autoclave experiments.

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Organic azide synthesis in microreactors: from optimization to lab scale production
Radboud University

The formation of benzyl azide by diazotransfer to benzyl amine was screened and subsequently scaled up using continuous flow chemistry.

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Automated Sample Pretreatment of Environmental
Dionex Corporation

Matrix elimination is a method of sample preparation that removes certain matrix species from a sample, typically by specifically binding matrix species to a solid phase. Interfering compounds can be removed before the analyte determination, thus improving the quality of results as well as lengthening the lifetime of consumables such as columns.

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Five noncovalent peptidic ligands show different affinity rankings in solution and gas phase
Institute for Research in Biomedicine (IRB), Barcelona Science Park, University of Barcelona, Spain

Stability of noncovalent complexes of VEGF protein with 5 peptidic ligands is studied. Experiments were conducted in solution (NMR CSP, ITC) and in gas phase (CID TOF MS). Each ligand differs from others in chirality of one amino acid. It was shown, that trend of stability of the studied noncovalent complexes is reversed in the gas phase relatively to the solution. An explanation of this behavior is presented.

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Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor
Federal University of São Carlos

An inadequate transfer of oxygen can lead to rapid changes in cell physiology, metabolism, and cell death. In this work, the KLa is evaluated in a Taylor vortex flow bioreactor and a mass transfer correlation is proposed. The experimental conditions employed were: rotational Reynolds number between 244 and 2928, airflow rates varying from 80 mL.min-1 to 550 mL.min-1 and used culture medium DMEM.

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Hyperbaric Bioreactors use with Yarrowia Lipolytica Cultures: Cellular Adaptation to Hyperbaric Conditions
IBB-Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho, Braga, Portugal

In this work, a pressurized bioreactor was used for Y. lipolytica batch cultivation under increased air pressure from 1 bar to 6 bar. Cell growth was strongly enhanced by the pressure rise. The increase of oxygen availability caused the induction of the antioxidant enzyme SOD. The pre-growth of Y. lipolytica under increased pressure conditions did not affect the lipase production ability of the cells.

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Adaptive control of glycerol & methanol feeding in recombinant Pichia pastoris cultures: Impact on antibody titre
CQFB/REQUIMTE and IBET/ITQB

Pichia pastoris processes for heterolougous protein expression are typically run in three phases: a batch phase, an exponential feeding fed-batch phase and a long oxygen transfer limitation (OTL) phase. The final protein titre is often limited by the oxygen availability in the OTL phase. Here a direct adaptive controller is designed for the OTL phase. The controller was validated in pilot P. pastoris cultivations expressing a single chain antibody fragment (ScFv). This work shows that the propos

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Scalability of heterogeneous MW-heated processes
DSM Research

The combination of flow chemistry and microwave heating offers a unique opportunity to scale out heterogeneous microwave-assisted organic reactions. The feasibility of this setup is depending on the presence of a microwave effect, safety issues and energy efficiency.

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Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega
BMG Labtech

The Oris™ Cell Migration Assays from Platypus offer certain advantages over traditional migration assays. Especially the TriCoated kits enable the researcher to test the effect of different extracellular matrix components like Collagen I or Fibronectin on migration. In this application note we show the real-time monitoring of cell migration using a POLARstar Omega from BMG LABTECH equipped with a CO2 gas vented system.

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Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices

Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional

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Examples of FRX Applications for Demonstration
Syrris Ltd

FRX as a product offers a wide range of applications in a number of areas. To try and increase the exposure of the product to a wider audience, two standard demonstrations are detailed here. The first is a Wittig reaction showing the operation of an FRX200 system. The second is a separation of water and ethyl acetate demonstrating the operation of the FLLEX (Flow Liquid Liquid EXtraction module), for FRX300 or FRX400.

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Cleaning Microreactors
Syrris Ltd

This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.

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The Basics of Flow Chemistry
Syrris Ltd

This application note gives information on the basics of flow chemistry, with particular reference to the FRX system.

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Planning Successful Reactions
Syrris Ltd

This application note gives hints and tips for planning successful FRX reactions.

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Superheating Reactions
Syrris Ltd

When using the Pressurisation Module, the FRX system can be easily pressurised up to 7bar. This allows reactions to be performed at temperatures much higher than atmospheric reflux, enabling faster and often cleaner, higher yielding reactions. This application note describes the practicalities of superheating reactions and the suggested maximum temperatures for common solvents.

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Reaction Optimisation and Large Scale Synthesis
Syrris Ltd

A major benefit of flow chemistry is the ease and consistency of reaction scale up. In a flow reactor, high quality, reproducible mixing, excellent temperature control and superheating are maintained when increasing reaction volume.

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Analysis of Baculovirus in media on deltaDOT’s CE platform
deltaDOT

Here we describe a rapid, highly quantitative method used to analyse Baculovirus in growth media that is also applicable for real time monitoring of viral growth. Reproducibility by migration time was shown to be <0.6%.The current analytical techniques for the analysis of virus concentration in growth media is time consuming (24hrs minimum), labour intensive and has limited value for quantitation.

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Analysis of E.coli lysate using Peregrine High Performance Capillary Electrophoresis (HPCE) with Label Free Intrinsic Imaging (LFII™)
deltaDOT

Analytical instruments with the capability of analyzing complex mixture of bio-molecules with high precision, excellent reproducibility and quantitative indications are highly sought after in fields ranging from routine quality control procedure in bio-molecule production to biomarker discovery and diagnostic industry. This application note describes the high resolution separation and subsequent molecular weight characterization of four of the most abundant protein in E. coli cell lysate, using

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