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Webcasts
Webcast - Flow Chemistry from Milligrams to Metric TonsFlow Chemistry from Milligrams to Metric Tons
Scott May, Eli Lilly & Co, speaking at Flow Chemistry Congress 2014.
Webcast - Catalysis in Flow: Operando Study of Pd Catalyst Speciation and LeachingCatalysis in Flow: Operando Study of Pd Catalyst Speciation and Leaching
Mimi Hii, Imperial College, speaking at Flow Chemistry Congress 2014.

Market Reports
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Flow Chemistry Market by Reactor Type, Application & Geography - Trends & Forecast to 2018
MarketsandMarkets

This report Flow Chemistry Market is segmented by type of reactor with major focus on micro reactor systems. The micro reactor system market is further segmented by type along with geography and applications.
Glucosamine
RI Technologies

The report serves as a guide to glucosamine industry covering more than 240 companies that are engaged in glucosamine R&D, processing, production, and distribution.
Chiral Chemicals
RI Technologies

This report focuses on the different methods and applications of Chiral Chemicals and their impact. The study provides global market analysis for preparation of chiral chemicals by traditional, asymmetric and biological methodologies.
Active Pharmaceutical Ingredients (API) Global Market to 2017 - Growth in Developing Markets to Come From Cost Efficient Manufacturing and Rising Domestic Demand
Global Data

GBI Research's report, “Active Pharmaceutical Ingredients (API) Global Market to 2017 - Growth in Developing Markets to Come From Cost Efficient Manufacturing and Rising Domestic Demand” provides detailed insight into the global APIs market. The research presents detailed analysis and forecasts of the major economic and market trends affecting the global APIs market.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Scientific News
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
High Temperature Synthesis Using Heating Blocks
Asynt DrySyn MULTI heating block systems are being utilised to support ground breaking synthetic research in photovoltaics, water splitting and nanoimaging.
Lonely Bacteria are More Likely to Become Antibiotic-resistant
Scientists from the University of Manchester have discovered that microbes in smaller groups are more likely to mutate, resulting in higher rates of antibiotic resistance.
Lab Scale Manufacturing Using Continuous Crystallization
A new METTLER TOLEDO On-demand webinar explores recent research that could revolutionize pharmaceutical production.
MIT Chemists Devise Novel Way to Manufacture Peptide Drugs
New, fast synthetic method enables manufacture of peptides in hours, which could boost drug development.
The Future Of Photochemistry
The Vapourtec UV-150 offers potential routes for novel compounds and building blocks together with possible new manufacturing processes.
Continuous-Flow Heck Synthesis of 4-Methoxybiphenyl and Methyl 4-Methoxycinnamate in scCO2 Expanded Solvent Solutions
This paper reports the Heck reaction between 4-iodoanisole and either styrene or methyl acrylate in a continuous flow reactor.
Silica: An Efficient Catalyst for One-Pot Regioselective Synthesis of Dithioethers
Researchers demonstrate that the choice of silica gel, either dry or moistened, could lead to highly selective pathways for the preparation of different dithioethers.
Flow Synthesis of Phenylserine using Threonine Aldolase Immobilized on Eupergit Support
Researchers from Eindhoven University of Technology have made the first step towards a critical view on the commercial potential for high-priced pharmaceutical products using enzymatic microreactor technology.
One-Step Synthesis of Pyridines and Dihydropyridines in a Continuous Flow Microwave Reactor
Microwave-assisted synthesis has revolutionized many processes in recent years as a valuable alternative to the use of conductive heating.
Business News
SP Industries Acquires Bel-Art Products
Through this acquisition, SP adds to its portfolio over 3,500 additional products sold under Bel-Art’s flagship Scienceware and H-B Instrument brand names.
Endo to Acquire DAVA Pharmaceuticals
The acquisition enhances Endo's commercialization and development platform and is expected to be immediately accretive to company's 2014 adjusted earnings per share.
Onyx to Invest in Continuous Flow Technology
Significant investment into continuous flow manufacturing will allow Onyx's customers to explore alternatives during product research and development programs.
Intertek Expands San Diego Immunochemistry Center of Excellence
Intertek to expand its immunochemistry facility in San Diego with a move to a larger center of excellence.
Fujifilm Diosynth Biotechnologies Continues Expansion of R&D Facilities
Investment of over US$5.6m in new laboratories and equipment.
World-Class Scientists to take the Reins of New Nottingham ‘Green’ Lab
Professors Jairton Dupont, David Amabilino and Lam Hon will work at the laboratory which is due for completion early 2015.
Merck to Acquire Idenix
Acquisition expands portfolio of promising investigational therapies for Hepatitis C.
B-MS, Syngene Extend Research Collaboration
Companies announce a five-year extension of their drug discovery and development collaboration in India.
Malvern to Acquire MicroCal Business from GE
Malvern Instruments has entered into an agreement with GE Healthcare Life Sciences to acquire the company’s MicroCal™ microcalorimetry business.
WuXi PharmaTech Begins Operation of New HPAPI Laboratory
Adds HPAPI processing capabilities at Shanghai lab.

Events
14th Belgian Organic Synthesis
13 Jul 2014
14th Belgian Organic Synthesis ...
More information
BIT
21 Sep 2014
BIT's 5th Annual Global Congre ...
More information
Pharmaceutical and Medical Dev
24 Sep 2014
Pharmaceutical and Medical Dev ...
More information
MipTec 2014 The Leading Europe
23 Sep 2014
MipTec 2014 The Leading Europe ...
More information

ePosters
Microwave Assisted Green Synthesis of Aspirin From Over The Counter Pain Creams
Division of Natural Science, Mount Saint Mary College, NY

A successful microwave synthesis of methyl salicylate to aspirin using green catalysts from over the counter pain creams. The process was also prepared and tested in an undergraduate organic chemistry lab.
Functional Monoliths for Flow Processes by RAFT Polymerisation
CSIRO MATERIALS SCIENCE & ENGINEERING

Polymeric monoliths have recently emerged as a new class of solid supports for stoichiometric and catalytic reactions in continuous flow synthesis.
Marking of Weighing Equipment for Hazardous Areas
Mettler Toledo

This poster outlines typical markings for hazardous areas.
Recycled Gas Flow Control to Optimize Reaction Conversion and the Accomplishment of Heat Integration in Benzene Production through Hydrodealkylation of Toluene
ETH Zurich

In this work, a benzene production plant through hydrodealkylation process was investigated through a simulation by Aspen Plus V7.2® and run based on the real data obtained from a benzene production plant operating in the United States.
Recycled Gas Flow Control to Optimize Reaction Conversion and the Accomplishment of Heat Integration in Benzene Production through Hydrodealkylation of Toluene
ETH Zurich

In this work, a benzene production plant through hydrodealkylation process was investigated through a simulation by Aspen Plus V7.2® and run based on the real data obtained from a benzene production plant operating in the United States.
Marking of Weighing Equipment for Hazardous Areas
Mettler Toledo

This poster outlines typical markings for hazardous areas.
Concentration and Mixing Effects on the Production of Amine Hydrochloride Salts in a Confined Impinging Jet Reactor
University of Alberta

Results show that different AHC salts can be formed under different process conditions.
A mix-and-read cell-based assay for antibody screening against Epithelial Growth Factor Receptor
TTP Labtech

Here we present a sensitive robust, mix-and-read method for the screening of antibodies against cell surface proteins. With its simple operation, no-wash format, and high sensitivity, this new method is well-suited for high throughput antibody screening.
"Some Like it Hot" - Continuous Flow Chemistry at High Temperatures and Pressures
University of Graz

More and more recently published chemistry examples in glass-chip- and Teflon based microreactors begin to exploit the possibility of superheating solvents for process intensification leading to drastically shortened reaction times.
Quality Standards for 14C API for use in human clinical studies
Quotient Bioresearch

The Good Manufacturing Practice (GMP) state that the active pharmaceutical ingredient (API) intended for use in early stage clinical trials should be of "suitable" quality. The Clinic Ready quality standard ensures that the API is synthesised with all the appropriate documentation to facilitate QP release of the final IMP for guman clinical dosing.
Application Notes
Comparing HPCCC to RP-HPLC for Kilo Scale Purification of Spinetoram
Dynamic Extractions

Spinetoram is a semi-synthetic insecticide produced by Dow AgroSciences. HPCCC method improved the kilo scale separation. The aim is to purify both components to >97% purity. HPCCC method improved the kilo scale separation.
Simultaneously Reducing your API Cost of Goods and Carbon Footprint
Dynamic Extractions Ltd

High Performance Continuous Extraction Technology can improve manufacturing efficiency and increase the green credentials of a production facility. This service offering is a result of a 3 year industry funded project that was supported by both GSK and Pfizer. A toll refining offering allows access to the technique with minimal risk to the customer. Future on-site deployment of can be assessed for supply of equipment for on-site installation.
Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega
BMG Labtech

The Oris™ Cell Migration Assays from Platypus offer certain advantages over traditional migration assays. Especially the TriCoated kits enable the researcher to test the effect of different extracellular matrix components like Collagen I or Fibronectin on migration. In this application note we show the real-time monitoring of cell migration using a POLARstar Omega from BMG LABTECH equipped with a CO2 gas vented system.
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices

Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Examples of FRX Applications for Demonstration
Syrris Ltd

FRX as a product offers a wide range of applications in a number of areas. To try and increase the exposure of the product to a wider audience, two standard demonstrations are detailed here. The first is a Wittig reaction showing the operation of an FRX200 system. The second is a separation of water and ethyl acetate demonstrating the operation of the FLLEX (Flow Liquid Liquid EXtraction module), for FRX300 or FRX400.
Cleaning Microreactors
Syrris Ltd

This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
The Basics of Flow Chemistry
Syrris Ltd

This application note gives information on the basics of flow chemistry, with particular reference to the FRX system.
Planning Successful Reactions
Syrris Ltd

This application note gives hints and tips for planning successful FRX reactions.
Superheating Reactions
Syrris Ltd

When using the Pressurisation Module, the FRX system can be easily pressurised up to 7bar. This allows reactions to be performed at temperatures much higher than atmospheric reflux, enabling faster and often cleaner, higher yielding reactions. This application note describes the practicalities of superheating reactions and the suggested maximum temperatures for common solvents.
Reaction Optimisation and Large Scale Synthesis
Syrris Ltd

A major benefit of flow chemistry is the ease and consistency of reaction scale up. In a flow reactor, high quality, reproducible mixing, excellent temperature control and superheating are maintained when increasing reaction volume.
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