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Thursday, October 23, 2014
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Catalysis in Flow: Operando Study of Pd ...
Small Footprint Capillary-Flow NMR and t...Flow Chemistry from Milligrams to Metric...Towards Chemo-Enzymatic Reactions under ...

Featured Products
Featured Product - FlowIR For Continuous Flow Chemistry
FlowIR For Continuous Flow Chemistry
Featured Product - ReactoMate CLR systems: Innovative and safe jacketed glass reactor vessel systems from 50ml to 30,000ml
ReactoMate CLR systems: Innovative and safe jacketed glass reactor vessel systems from 50ml to 30,000ml

Webcasts
Webcast -  Early Transition Metal Chemistry in Flow - Making Known and New Discovery Faster and Easier Early Transition Metal Chemistry in Flow - Making Known and New Discovery Faster and Easier
Tyler McQuade, DARPA, speaking at Flow Chemistry Congress 2014
Webcast - Accelerating Photochemical Processes in Continuous-flow MicroreactorsAccelerating Photochemical Processes in Continuous-flow Microreactors
Timothy Noel, Eindhoven University of Technology, speaking at Flow Chemistry Congress 2014

Market Reports
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Flow Chemistry Market by Reactor Type, Application & Geography - Trends & Forecast to 2018
MarketsandMarkets

This report Flow Chemistry Market is segmented by type of reactor with major focus on micro reactor systems. The micro reactor system market is further segmented by type along with geography and applications.
Glucosamine
RI Technologies

The report serves as a guide to glucosamine industry covering more than 240 companies that are engaged in glucosamine R&D, processing, production, and distribution.
Chiral Chemicals
RI Technologies

This report focuses on the different methods and applications of Chiral Chemicals and their impact. The study provides global market analysis for preparation of chiral chemicals by traditional, asymmetric and biological methodologies.
Active Pharmaceutical Ingredients (API) Global Market to 2017 - Growth in Developing Markets to Come From Cost Efficient Manufacturing and Rising Domestic Demand
Global Data

GBI Research's report, “Active Pharmaceutical Ingredients (API) Global Market to 2017 - Growth in Developing Markets to Come From Cost Efficient Manufacturing and Rising Domestic Demand” provides detailed insight into the global APIs market. The research presents detailed analysis and forecasts of the major economic and market trends affecting the global APIs market.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Scientific News
Syrris Atlas has the Midas Touch with Nanoparticles
Spanish biotechnology company Midatech Biogune is taking advantage of our Atlas Potassium reactor systems to produce custom-made functionalized gold nanoparticles for medicinal use.
Simple, Rapid and Effective Method for Ammonia Determination
Researchers have a developed a modern, miniaturized and economic flow system to overcome problems of using Nessler's reagent for ammonia determination.
Preparation of Phosphines Through C–P Bond Formation
This article reviews some of the most important C–P bond formation strategies, organizing them according to the hybridization of carbon in the newly formed C–P bond.
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
High Temperature Synthesis Using Heating Blocks
Asynt DrySyn MULTI heating block systems are being utilised to support ground breaking synthetic research in photovoltaics, water splitting and nanoimaging.
Lonely Bacteria are More Likely to Become Antibiotic-resistant
Scientists from the University of Manchester have discovered that microbes in smaller groups are more likely to mutate, resulting in higher rates of antibiotic resistance.
Lab Scale Manufacturing Using Continuous Crystallization
A new METTLER TOLEDO On-demand webinar explores recent research that could revolutionize pharmaceutical production.
MIT Chemists Devise Novel Way to Manufacture Peptide Drugs
New, fast synthetic method enables manufacture of peptides in hours, which could boost drug development.
The Future Of Photochemistry
The Vapourtec UV-150 offers potential routes for novel compounds and building blocks together with possible new manufacturing processes.
Continuous-Flow Heck Synthesis of 4-Methoxybiphenyl and Methyl 4-Methoxycinnamate in scCO2 Expanded Solvent Solutions
This paper reports the Heck reaction between 4-iodoanisole and either styrene or methyl acrylate in a continuous flow reactor.
Business News
Ashland Opens Pharmaceutical Center of Excellence in Wilmington
Increasing pharmaceutical technologies capabilities to address global drug development and bioavailability enhancement trends.
Lilly to Close One of Three Manufacturing Operations in Puerto Rico
Manufacturing at Guayama will conclude while investments continue in Carolina.
TAP and Gallus Co-host Free Webinar
Explaining the benefits of using ambr15 microbioreactors for DoE.
New Webinars Explore Feed Strategy Challenges Using Mini Bioreactors
Detailing how to achieve consistent feeding regimes for reproducible scale-up.
Relypsa and Patheon Agreement
Relypsa announces commercial manufacturing agreement with Patheon, Inc.
Almac Forms Academia-Industry Collaboration
Collaboration aims to bring a novel chemical produced via an enzymatic route from under-utilised natural oil to the market.
Catalent And Minomic Collaborate
Collaboration aims to bring new prostate cancer treatment to market.
Vapourtec Sees Flow Chemistry Growth in India
A distribution partnership with Mumbai-based Pi-Process Intensification has enabled Vapourtec to establish a burgeoning market for its flow chemistry systems.
Novartis to Invest $35M in Gamida Cell
Novartis will receive 15% equity and an option to fully acquire Gamida Cell.
WuXi Facility Passes FDA API Manufacture Inspection
Company's wholly owned subsidiary Shanghai SynTheAll Pharmaceutical (STA) passed an FDA inspection in July for the manufacture of the active pharmaceutical ingredient (API) for a branded commercial drug.

Events
Lab Innovations 2014
05 Nov 2014
Lab Innovations 2014 ...
More information
HPAPI World Congress
12 Nov 2014
HPAPI World Congress ...
More information
European Pharma M2R 2014
13 Nov 2014
European Pharma M2R 2014 ...
More information
Continuous Manufacturing in Bi
18 Nov 2014
Continuous Manufacturing in Bi ...
More information

ePosters
Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor
MRCT

An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.
Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
Department of Chemistry, Virginia Tech,Virginia Tech Carilion Research Institute

We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.
Novel Gpr39 Agonists: Correlation Of Binding Affinity Using Label-Free Back-Scattering Interferometry With Potency In Functional Assays
(1)Molecular Sensing, Inc., Nashville, Tennessee, USA, (2) AstraZeneca Discovery Sciences, Mölndal, Sweden, (3) AstraZeneca CVMD iMED, Mölndal, Sweden

We describe the application of back-scattering interferometry (BSI) to the characterization of small molecule ligand binding to human GPR39 (a GPCR targeted for type-2 diabetes therapy) overexpressed in crude membrane fractions in free solution, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds.
Mixtures Analysis of Complex Mixtures
Mestrelab Research

We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.
Novel Gpr39 Agonists: Correlation Of Binding Affinity Using Label-Free Back-Scattering Interferometry With Potency In Functional Assays
(1) Molecular Sensing, Inc., Nashville, Tennessee, USA, (2) AstraZeneca Discovery Sciences, Mölndal, Sweden, (3) AstraZeneca CVMD iMED, Mölndal, Sweden

We describe the application of back-scattering interferometry (BSI) to the characterization of small molecule ligand binding to human GPR39 (a GPCR targeted for type-2 diabetes therapy) overexpressed in crude membrane fractions in free solution, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds
A Novel Approach Toward Microfluidic Drug Metabolite Synthesis – Electrosynthetic Methodology Simulating Cytochrome (CYP450) Oxidation
Sanford Burnham Medical Research Institute at Lake Nona and Syrris Ltd

A novel microfluidic technology and electrochemical synthesis method is demonstrated for the efficient generation of known drug metabolites. These metabolites are typically generated on first pass hepatic oxidation in vivo. The FLUX Module, a new microfluidic electrochemical cell manufactured by Syrris Ltd., has been employed to generate the metabolites of five commercial drugs: Tolbutamide, Chlorpromazine, Diclofenac, Primidone and Albendazole.
Microwave Assisted Green Synthesis of Aspirin From Over The Counter Pain Creams
Division of Natural Science, Mount Saint Mary College, NY

A successful microwave synthesis of methyl salicylate to aspirin using green catalysts from over the counter pain creams. The process was also prepared and tested in an undergraduate organic chemistry lab.
Functional Monoliths for Flow Processes by RAFT Polymerisation
CSIRO MATERIALS SCIENCE & ENGINEERING

Polymeric monoliths have recently emerged as a new class of solid supports for stoichiometric and catalytic reactions in continuous flow synthesis.
Marking of Weighing Equipment for Hazardous Areas
Mettler Toledo

This poster outlines typical markings for hazardous areas.
Recycled Gas Flow Control to Optimize Reaction Conversion and the Accomplishment of Heat Integration in Benzene Production through Hydrodealkylation of Toluene
ETH Zurich

In this work, a benzene production plant through hydrodealkylation process was investigated through a simulation by Aspen Plus V7.2® and run based on the real data obtained from a benzene production plant operating in the United States.
Application Notes
Comparing HPCCC to RP-HPLC for Kilo Scale Purification of Spinetoram
Dynamic Extractions

Spinetoram is a semi-synthetic insecticide produced by Dow AgroSciences. HPCCC method improved the kilo scale separation. The aim is to purify both components to >97% purity. HPCCC method improved the kilo scale separation.
Simultaneously Reducing your API Cost of Goods and Carbon Footprint
Dynamic Extractions Ltd

High Performance Continuous Extraction Technology can improve manufacturing efficiency and increase the green credentials of a production facility. This service offering is a result of a 3 year industry funded project that was supported by both GSK and Pfizer. A toll refining offering allows access to the technique with minimal risk to the customer. Future on-site deployment of can be assessed for supply of equipment for on-site installation.
Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega
BMG Labtech

The Oris™ Cell Migration Assays from Platypus offer certain advantages over traditional migration assays. Especially the TriCoated kits enable the researcher to test the effect of different extracellular matrix components like Collagen I or Fibronectin on migration. In this application note we show the real-time monitoring of cell migration using a POLARstar Omega from BMG LABTECH equipped with a CO2 gas vented system.
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices

Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Examples of FRX Applications for Demonstration
Syrris Ltd

FRX as a product offers a wide range of applications in a number of areas. To try and increase the exposure of the product to a wider audience, two standard demonstrations are detailed here. The first is a Wittig reaction showing the operation of an FRX200 system. The second is a separation of water and ethyl acetate demonstrating the operation of the FLLEX (Flow Liquid Liquid EXtraction module), for FRX300 or FRX400.
Cleaning Microreactors
Syrris Ltd

This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
The Basics of Flow Chemistry
Syrris Ltd

This application note gives information on the basics of flow chemistry, with particular reference to the FRX system.
Planning Successful Reactions
Syrris Ltd

This application note gives hints and tips for planning successful FRX reactions.
Superheating Reactions
Syrris Ltd

When using the Pressurisation Module, the FRX system can be easily pressurised up to 7bar. This allows reactions to be performed at temperatures much higher than atmospheric reflux, enabling faster and often cleaner, higher yielding reactions. This application note describes the practicalities of superheating reactions and the suggested maximum temperatures for common solvents.
Reaction Optimisation and Large Scale Synthesis
Syrris Ltd

A major benefit of flow chemistry is the ease and consistency of reaction scale up. In a flow reactor, high quality, reproducible mixing, excellent temperature control and superheating are maintained when increasing reaction volume.
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