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Webcast - Handling Slower Reactions in Flow Handling Slower Reactions in Flow
Robert Ashe, AM Technology, speaking at Flow Chemistry India 2015
Webcast - Photocontrolled Polymerizations in Flow: Next Generation Material SynthesisPhotocontrolled Polymerizations in Flow: Next Generation Material Synthesis
Thomas Junkers, Hasselt University, speaking at Flow Chemistry India 2015

Market Reports
Scientific News
Chemical Design Made Easier
Rice University scientists prepare elusive organocatalysts for drug and fine chemical synthesis.
2015 ACS GCI Pharmaceutical Roundtable Research Grant
Request for proposals: Greener Continuous Chemistry & Engineering Technology.
'Crumpled' Filter to Slash Energy Consumption
Scientists have developed an ultra-thin, super-strong membrane to filter liquids and gases, with the potential to cut energy consumption in industry.
Tackling Chemical Safety Rules and Regulations
Helsinki Chemicals Forum continues to lead international chemicals safety and management discussions.
Pioneering New Method to Map Enzyme Activity
Cardiff University researchers new discovery could have wide-reaching implications for the creation of manufactured goods, biofuels and therapeutic drugs.
Euro Vision turns Reality for Australia’s Iconic ‘Green Whistle’
Patients will soon benefit from a unique invention, with emergency pain killer Penthrox receiving initial regulatory approval for sale in the European and UK markets.
Gaining the Full Benefit of Microflow Electrolysis Cells
This paper sets out the factors that should be considered in seeking good performance from microflow cells for organic electrosynthesis.
Are Chemical Safety Regulations Changing Your Laboratory?
GHS changes to country chemical regulations affect everyone.
Continuous Flow of Breakthroughs for Vapourtec
Flow chemistry systems designed and manufactured by Vapourtec have recently reached the milestone of having been cited in 150 peer review publications.
A Continuous Flow System for the Measurement of Ambient Nitrogen Oxides
The proposed method can be used in industrial locations to continuously monitor ambient NOx levels and it can be automated for measuring the variation of NOx concentrations.
Business News
National Graphene Institute Reveals First Results With Industrial Partner
The first official experimental results since the National Graphene Institute (NGI) opened in March have been produced. The novel collaboration between industry and academia is exploring the production of graphene in the first stage of a long-term project.
Process Safety Competence Matters
Trish Kerin wins John A Brodie Medal that recognizes her excellent work and leadership.
VWR Acquires Purification Technologies
Acquisition extends VWR's solvent manufacturing capabilities.
CPhI Experts Predict Continuous Manufacturing for All Within 10-years
Brian Carlin emphasizes need to build flexibility into design to manage impact of raw material variability through product lifecycle.
Ingenza Embarks on GSK Collaboration
Ingenza Ltd, a world leader in the application of industrial biotechnology and synthetic biology, is pleased to announce that it is collaborating with global healthcare company GlaxoSmithKline (GSK) on an innovative research project.
Exhibitors Quick to Sign Up for Lab Innovations 2015
More than 100 industry leading suppliers have already booked stands for Lab Innovations 2015, which returns to Birmingham’s NEC on 4 & 5 November 2015.
Innovation is at the Heart of the Laboratory Industry
For its fourth edition, the show welcomes a whole host of first time exhibitors, launches an educational theatre and introduces an exciting new feature.
Goodwin Biotechnology and Aspyrian Therapeutics Collaborate
Collaboration on the successful GMP manufacturing and IND submission for a novel Antibody Drug Conjugate platform.
Tim Jamison and Aaron Beeler Launch Snapdragon Chemistry, Inc.
Tim Jamison, professor of chemistry, MIT, and Aaron Beeler, assistant professor of chemistry, Boston University, have launched of Snapdragon Chemistry, Inc., to help companies harness the advantages and opportunities of continuous flow synthesis.
New Cambridge, Office for Alfa Aesar
New and exciting chapter in Alfa Aesar’s UK history.

Photochemical Transformations
09 Dec 2015
Photochemical Transformations ...
More information
Implementation of Flow Chemist
21 Dec 2015
Implementation of Flow Chemist ...
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WCBP 2016: 20th Symposium on t
26 Jan 2016
WCBP 2016: 20th Symposium on t ...
More information
Flow Chemistry Europe 2016 - 6
16 Feb 2016
Flow Chemistry Europe 2016 - 6 ...
More information

An HTS-Compatible Plate For Highly Miniaturized Cultures Of Primary Human Bronchial Epithelial Cells At Air-Liquid Interface
1BellBrook Labs, Madison, WI, USA 2UAB Cystic Fibrosis Research Center, Birmingham, AL, USA

Primary human bronchial epithelial cells (HBE) cultured at air liquid interface (ALI) exhibit striking similarity to the in vivo situation, including both tissue architecture and ion channel functionality. Cultures of this type serve as a gold standard for predicting therapeutic activity in airway diseases such as cystic fibrosis.
The Prestwick Chemical Library (R), A Valuable Tool for Screening
1. Prestwick Chemical, 220 Blvd Gonthier d'Andernach, 67400 Strasbourg-Illkirch, FRANCE 2. University of Strasbourg, Therapeuthic Innovation Laboratory, UMR7200 CNRS, Faculty of Pharmacy, 74 route du

The Prestwick Chemical Library® (PCL) is Prestwick’s flagship product dedicated to screening. It is a collection of 1280 molecules comprising 100% approved drugs (FDA, EMEA and other agencies) selected for their high chemical and pharmacological diversity. The PCL was designed to reduce the risk of "low quality" hits and therefore the cost of the initial screening, and appears to be an efficient smart library for hit discovery. The PCL comes with an extended fully-annotated database.
Building a Diverse and Experimentally-Curated Fragment Library
Key Organics Limited, Cornwall, UK, NMX Research and Solutions, Montreal, Broad Institute, Cambridge, MA, USA CA,

Presenting a new fragment collection with experimentally-determined aqueous solubility that will address a major source of false positives and attrition in fragment screening
Polymer Microarrays for Biomaterial Development
1. School of Chemistry, University of Edinburgh 2. Queen’s Medical Research Institute, University of Edinburgh 3. Scottish HPV Reference Laboratory, Royal Infirmary, Edinburgh 4. Centre for Virus Res

The application of polymer microarrays in the discovery of biocompatible and bioactive substrates. Progress towards biomaterial development for the treatment of SIRS (systemic inflammatory response syndrome), and improving cervical cytology.
Jomo Kentyatta University of Agriculture and Technology (Kenya), and Foundation of Analytical Science and Technology in Africa (UK).

From this study, the pain killers sampled were found to have large error bars suggesting that there exist counterfeit drugs in the market. The brands mostly affected for analysis of acetaminophen were panadol, action, P500, P5500, elymol and neladol. The error bars for caffeine analysis were quite low indicating that all tablets either counterfeit or original maintained the same amount of this active ingredient.
Applications of scCO2 as a “Green” Solvent in the Textile Industry
Applied Separations, Halide Group

Using Supercritical CO2 to dye textiles.
Using Cresset to grow and link distant fragment hits with sensible chemistry

We describe a further extension to our fragment growing methodology to aid fragment optimisation through linking fragments that have been shown to bind to distinct (distant or adjacent) pockets.
A multi-resonances valveless micropump with high fluid transportation efficiency
Advanced Thermal Science and Flow Control Lab, Institute of Applied Mechanics, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei, 10617 Taiwan, Republic of China

A multi-resonances valveless micropump equipping with inlet/outlet elastic chambers of intendedly-designed stiffness was successfully realized to solve the low efficiency problem. Besides, a theoretical model based on Hydraulic-electrical-Analogy was also proposed to precisely predict its characteristics of dynamic behavior.
Rate and Mechanistic Investigation of Eu(OTf)2-Mediated Reduction of Graphene Oxide at Room Temperature
Department of Chemistry, Indian Institute of Technology Madras, Chennai-600 036, TN, India

Eu(OTf)2 has been introduced as an efficient reagent for the reduction of graphene oxide. Details kinetic studies have been performed which suggests that, the method is more efficient compared to that of other commonly used reduction methods.
Direct Targets Identification of a Bioactive Compound
Charnwood Molecular, Hybrigenics services SAS

Identifying protein partners of a small bioactive molecule is of great
interest in many aspects of life sciences and specifically in the drug
discovery and development process cycle. It is a support to (i) decipher
the mechanism of action after for example a “High Content” screening,
(ii) study “off-target” effects, (iii) adjust therapeutic indications and
clinical regimens of a drug and (iv) consider drug repositioning.
Application Notes
Detecting the Presence of Anomolous Large Particles Within Powders Using Laser Diffraction Particle Size Analysis
Malvern Instruments Limited

In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.
Measuring Small Quantities of Dry Powder Using the Aero S and Mastersizer 3000
Malvern Instruments Limited

In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials with good reproducibility and illustrating the dispersion abilities of the Aero S.
Comparing HPCCC to RP-HPLC for Kilo Scale Purification of Spinetoram
Dynamic Extractions

Spinetoram is a semi-synthetic insecticide produced by Dow AgroSciences. HPCCC method improved the kilo scale separation. The aim is to purify both components to >97% purity. HPCCC method improved the kilo scale separation.
Simultaneously Reducing your API Cost of Goods and Carbon Footprint
Dynamic Extractions Ltd

High Performance Continuous Extraction Technology can improve manufacturing efficiency and increase the green credentials of a production facility. This service offering is a result of a 3 year industry funded project that was supported by both GSK and Pfizer. A toll refining offering allows access to the technique with minimal risk to the customer. Future on-site deployment of can be assessed for supply of equipment for on-site installation.
Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega
BMG Labtech

The Oris™ Cell Migration Assays from Platypus offer certain advantages over traditional migration assays. Especially the TriCoated kits enable the researcher to test the effect of different extracellular matrix components like Collagen I or Fibronectin on migration. In this application note we show the real-time monitoring of cell migration using a POLARstar Omega from BMG LABTECH equipped with a CO2 gas vented system.
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices

Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Examples of FRX Applications for Demonstration
Syrris Ltd

FRX as a product offers a wide range of applications in a number of areas. To try and increase the exposure of the product to a wider audience, two standard demonstrations are detailed here. The first is a Wittig reaction showing the operation of an FRX200 system. The second is a separation of water and ethyl acetate demonstrating the operation of the FLLEX (Flow Liquid Liquid EXtraction module), for FRX300 or FRX400.
Cleaning Microreactors
Syrris Ltd

This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
The Basics of Flow Chemistry
Syrris Ltd

This application note gives information on the basics of flow chemistry, with particular reference to the FRX system.
Planning Successful Reactions
Syrris Ltd

This application note gives hints and tips for planning successful FRX reactions.
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