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Webcasts
Webcast - Innovative Benign-by-design Flow Chemistry Protocols: From Nanomaterials Synthesis to Biomass/Waste Valorization Innovative Benign-by-design Flow Chemistry Protocols: From Nanomaterials Synthesis to Biomass/Waste Valorization
On demand webinar from Professor Rafael Luque, Universidad de Cordoba.
Webcast - Photochemical Transformations Accelerated in Continuous-flow MicroreactorsPhotochemical Transformations Accelerated in Continuous-flow Microreactors
Professor Timothy Noël, Eindhoven University of Technology, free to attend webinar.

Market Reports
Scientific News
Cutting the Cost of Drug-Building Chemicals
EPFL scientists have developed a method to produce aryl-containing amines in a cheap and easily scalable way.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
Porphyrins as Catalysts in Scalable Organic Reactions
This review covers the most relevant scalable porphyrin-catalysed procedures, showing how these compounds represent broad applications in chemistry.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
New Cancer Fighters Emerge From Lab
Rice University lab simplifies total synthesis of anti-cancer agent.
Pharmacy on Demand
New, portable system can be configured to produce different drugs.
Safer, Cheaper, Greener and More Efficient System for Organic Synthesis
The new medium not only supports organic synthesis it also produces considerably higher yields of product than pure organic solvents.
Countless New, Cleaner Uses of Methane
Chemists have demonstrated the potential to use methane as a versatile chemical building block with which to make more complex molecules.
New Way to Control Chemical Reactions
Scientists have harnessed static electricity to control chemical reactions for the first time, in a breakthrough that could bring cleaner industry and cheaper nanotechnology.
Business News
Syrris Celebrates 15 Years of Chemisty Innovation
Syrris marks 15 years of innovation since its founding in August 2001.
Flow Chemistry for Process Development
Discover flow chemistry methods used to expedite process development during a free live online symposium.
New Programming Chair for the AIChE CRE Division
Assistant Professor Ryan L. Hartman from the NYU Tandon School of Engineering has been elected to a five-year term as the programming chair of the American Institute of Chemical Engineers (AIChE) Catalysis and Reaction Engineering division.
Dow and DuPont Stockholders Approve Merger
Companies expect the merger transaction to close in the second half of 2016, subject to customary closing conditions and receipt of regulatory approvals.
$736M Deal: Sagent Pharmaceuticals Acquisition by Nichi-Iko
Nichi-Iko in two step merger agreement with Sagent Pharmaceuticals at $21.75 per share.
Dalton Receives Compliant Rating From Health Canada
The rating resulted from a Good Manufacturing Practices (GMP) inspection conducted at Dalton’s facility during March 2016.
Snapdragon Announces New Labs in Cambridge
Snapdragon Chemistry announces expansion to new labs in Cambridge, added technical services, and election of Matt Bio as chief executive officer.
METTLER TOLEDO Announces a New Symposium on Process Chemistry and Scale-Up
Company has announced that the discover methods entitled Process Chemistry and Scale-up Online Seminar featuring R&D scientists from Air Products and Nalas Engineering.
Advances in Flow Chemistry
Discovering the latest developments at Flow Chemistry Europe 2016.
Big Data and Analytics Can Tame Rising Cost of Chemical R&D
Novel sensors, cheminformatics, and advanced analytics can help bring new products to market faster and cheaper in the chemical industry, according to Lux Research.

Events
Quality Excellence: From Quali
28 Sep 2016
Quality Excellence: From Quali ...
More information
World Vaccine Congress Europe
10 Oct 2016
World Vaccine Congress Europe ...
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World Veterinary Vaccine Congr
10 Oct 2016
World Veterinary Vaccine Congr ...
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International conference on Ap
17 Oct 2016
International conference on Ap ...
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ePosters
Targeting Acute Pancreatitis by Small Molecule Inhibitors of Cyclophilin D
The University of Liverpool

Cyclophilin D (CypD) promotes opening of the mitochondrial permeability transition pore, a major contributor to acute pancreatitis. We are developing small molecule inhibitors of CypD as a possible treatment for AP and other conditions where the MPTP plays a role.
The Pathogen Box: A Catalyst for Neglected Disease Drug Discovery
Medicines for Malaria Venture, Switzerland

Modelled after the Malaria Box, the Pathogen Box contains ~400 diverse drug-like molecules active against neglected diseases of interest such as Chagas disease, cryptosporidiosis, hookworm, sleeping sickness, leishmaniasis, lymphatic filariasis, malaria, onchocerciasis, schistosomiasis, trichuriasis, tuberculosis.
Analysis of Terpenes Using Gas Chromatography with Vacuum Ultraviolet
The University of Texas at Arlington and VUV Analytics

The VUV absorption spectra for different terpenes were distinctive and differentiable. GC-VUV demonstrated the capabilities for qualitative and quantitative analysis of terpenes in turpertine mixtures. Chromatographic coeluting signals can be deconvolved by the VUV data analysis software.

Selective Debenzylation of N-Benzyloxypyrazinones in Flow
Molecular Design and Synthesis - Department of Chemistry - KU Leuven

Selective and reproducible debenzylation of benzyloxypyrazinones by using catalytic transfer hydrogenation in flow chemistry to yield N-hydroxypyrazinones. The flow methodology enabled us to avoid overreduction of the compounds to pyrazin-2(1H)-ones.
Predicting Regioselectivityand Labilityof Cytochrome P450 Metabolism using Quantum Mechanical Simulations
Optibrium

Predicting Regioselectivity and Lability of Cytochrome P450 Metabolism using Quantum Mechanical Simulations
An HTS-Compatible Plate For Highly Miniaturized Cultures Of Primary Human Bronchial Epithelial Cells At Air-Liquid Interface
1BellBrook Labs, Madison, WI, USA 2UAB Cystic Fibrosis Research Center, Birmingham, AL, USA

Primary human bronchial epithelial cells (HBE) cultured at air liquid interface (ALI) exhibit striking similarity to the in vivo situation, including both tissue architecture and ion channel functionality. Cultures of this type serve as a gold standard for predicting therapeutic activity in airway diseases such as cystic fibrosis.
The Prestwick Chemical Library (R), A Valuable Tool for Screening
1. Prestwick Chemical, 220 Blvd Gonthier d'Andernach, 67400 Strasbourg-Illkirch, FRANCE 2. University of Strasbourg, Therapeuthic Innovation Laboratory, UMR7200 CNRS, Faculty of Pharmacy, 74 route du

The Prestwick Chemical Library® (PCL) is Prestwick’s flagship product dedicated to screening. It is a collection of 1280 molecules comprising 100% approved drugs (FDA, EMEA and other agencies) selected for their high chemical and pharmacological diversity. The PCL was designed to reduce the risk of "low quality" hits and therefore the cost of the initial screening, and appears to be an efficient smart library for hit discovery. The PCL comes with an extended fully-annotated database.
Building a Diverse and Experimentally-Curated Fragment Library
Key Organics Limited, Cornwall, UK, NMX Research and Solutions, Montreal, Broad Institute, Cambridge, MA, USA CA,

Presenting a new fragment collection with experimentally-determined aqueous solubility that will address a major source of false positives and attrition in fragment screening
Polymer Microarrays for Biomaterial Development
1. School of Chemistry, University of Edinburgh 2. Queen’s Medical Research Institute, University of Edinburgh 3. Scottish HPV Reference Laboratory, Royal Infirmary, Edinburgh 4. Centre for Virus Res

The application of polymer microarrays in the discovery of biocompatible and bioactive substrates. Progress towards biomaterial development for the treatment of SIRS (systemic inflammatory response syndrome), and improving cervical cytology.
DETERMINATION OF THE QUALITY OF ACTIVE INGREDIENTS IN PAIN KILLERS USING GC-MS
Jomo Kentyatta University of Agriculture and Technology (Kenya), and Foundation of Analytical Science and Technology in Africa (UK).

From this study, the pain killers sampled were found to have large error bars suggesting that there exist counterfeit drugs in the market. The brands mostly affected for analysis of acetaminophen were panadol, action, P500, P5500, elymol and neladol. The error bars for caffeine analysis were quite low indicating that all tablets either counterfeit or original maintained the same amount of this active ingredient.
Application Notes
Integrating Automation and DOE to Streamline and Accelerate Quality by Design Activities for Process Chemistry
Unchained Labs

Unchained Labs' tools translate complex experiments into executable methods.
Detecting the Presence of Anomolous Large Particles Within Powders Using Laser Diffraction Particle Size Analysis
Malvern Instruments Limited

In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials dosed with large particles and to detect those large, anomalous particles.
Measuring Small Quantities of Dry Powder Using the Aero S and Mastersizer 3000
Malvern Instruments Limited

In this application note, we demonstrate the capability of the Aero S dry dispersion unit and the Mastersizer 3000 to measure small quantities of pharmaceutical materials with good reproducibility and illustrating the dispersion abilities of the Aero S.
Comparing HPCCC to RP-HPLC for Kilo Scale Purification of Spinetoram
Dynamic Extractions

Spinetoram is a semi-synthetic insecticide produced by Dow AgroSciences. HPCCC method improved the kilo scale separation. The aim is to purify both components to >97% purity. HPCCC method improved the kilo scale separation.
Simultaneously Reducing your API Cost of Goods and Carbon Footprint
Dynamic Extractions Ltd

High Performance Continuous Extraction Technology can improve manufacturing efficiency and increase the green credentials of a production facility. This service offering is a result of a 3 year industry funded project that was supported by both GSK and Pfizer. A toll refining offering allows access to the technique with minimal risk to the customer. Future on-site deployment of can be assessed for supply of equipment for on-site installation.
Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega
BMG Labtech

The Oris™ Cell Migration Assays from Platypus offer certain advantages over traditional migration assays. Especially the TriCoated kits enable the researcher to test the effect of different extracellular matrix components like Collagen I or Fibronectin on migration. In this application note we show the real-time monitoring of cell migration using a POLARstar Omega from BMG LABTECH equipped with a CO2 gas vented system.
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices

Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Examples of FRX Applications for Demonstration
Syrris Ltd

FRX as a product offers a wide range of applications in a number of areas. To try and increase the exposure of the product to a wider audience, two standard demonstrations are detailed here. The first is a Wittig reaction showing the operation of an FRX200 system. The second is a separation of water and ethyl acetate demonstrating the operation of the FLLEX (Flow Liquid Liquid EXtraction module), for FRX300 or FRX400.
Cleaning Microreactors
Syrris Ltd

This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
The Basics of Flow Chemistry
Syrris Ltd

This application note gives information on the basics of flow chemistry, with particular reference to the FRX system.
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