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 | Continuous Flow Multi-Step Organic Synthesis - Methods and Applications Tim Jamison, Professor at Massachusetts Institute of Technology, speaking at Flow Chemistry Congress 2012. |
 | Improving Organic Synthesis by Exploiting Flow Reactor Professor Paul Watts, The University of Hull, speaking at Flow Chemistry Congress 2012. |
Lab Instrument Rental Trends 2012
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
DOE in Assay Development Trends
HTStec
This report summarizes the results of HTStec’s global Pharma, Biotech and Academic Research web-based benchmarking survey on the use of design of experiments (DOE) in assay development (AD) carried out in June 2009.
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
DOE in Assay Development Trends
HTStec
This report summarizes the results of HTStec’s global Pharma, Biotech and Academic Research web-based benchmarking survey on the use of design of experiments (DOE) in assay development (AD) carried out in June 2009.
Imperial College Employs Parallel Synthesis to Develop Better Catalysts
Asynt DrySyn MULTI and parallel synthesis kits to provide safer, more convenient way to perform heated catalytic reactions in parallel.
Antimalarial Drug Launched
Twelve years after a breakthrough discovery in his UC Berkeley laboratory, professor of chemical engineering Jay Keasling is seeing his dream come true.
From Bead to Flask: Synthesis of a Complex ß-amido-amide for Probe-Development Studies
This study reports the synthesis of LLW62, which is a complex benzimidazole-substituted ß-amido-amide similar in structure to inhibitors of p21 that were reported previously to support studies of this compound as a biological probe.
Simultaneous Saccharification and Co-Fermentation for Bioethanol Production at Lab, PDU and Demo Scales
In this study, researchers designed a SSCF process and scaled up from lab to demo scale reaching 4% (w/v) ethanol using xylose rich corncobs.
Mechanochemistry Assisted Asymmetric Organocatalysis: A Sustainable Approach
This review highlights the progress in asymmetric organocatalytic reactions assisted by mechanochemical techniques.
Flow Photochemistry: Old Light Through New Windows
This review highlights the use of flow reactors in organic photochemistry, allowing a comparison of the various reactor types to be made.
Heterogeneously Catalyzed Continuous-Flow Hydrogenation Using Segmented Flow in Capillary Columns
Researchers have utilized wall-catalyzed segmented flow to overcome monitoring and yield problems.
Ask the Experts: The Challenges and Benefits of Flow Chemistry to Optimize Drug Development
In this article a variety of experts from within Medicinal Chemistry discuss key issues concerning the use of flow chemistry to optimize drug development.
A Quantitative Approach to Nucleophilic Organocatalysis
In this review article researchers demonstrate that important information can be obtained by specifically synthesizing relevant intermediates and studying the kinetics of their reactions with nucleophiles or electrophiles.
N-Heterocyclic Carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis
Cooperative catalysis is a powerful technique for the highly selective synthesis of a variety of target structures, in this commentary the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis will be highlighted.
Asynt DrySyn MULTI and parallel synthesis kits to provide safer, more convenient way to perform heated catalytic reactions in parallel.
Antimalarial Drug Launched
Twelve years after a breakthrough discovery in his UC Berkeley laboratory, professor of chemical engineering Jay Keasling is seeing his dream come true.
From Bead to Flask: Synthesis of a Complex ß-amido-amide for Probe-Development Studies
This study reports the synthesis of LLW62, which is a complex benzimidazole-substituted ß-amido-amide similar in structure to inhibitors of p21 that were reported previously to support studies of this compound as a biological probe.
Simultaneous Saccharification and Co-Fermentation for Bioethanol Production at Lab, PDU and Demo Scales
In this study, researchers designed a SSCF process and scaled up from lab to demo scale reaching 4% (w/v) ethanol using xylose rich corncobs.
Mechanochemistry Assisted Asymmetric Organocatalysis: A Sustainable Approach
This review highlights the progress in asymmetric organocatalytic reactions assisted by mechanochemical techniques.
Flow Photochemistry: Old Light Through New Windows
This review highlights the use of flow reactors in organic photochemistry, allowing a comparison of the various reactor types to be made.
Heterogeneously Catalyzed Continuous-Flow Hydrogenation Using Segmented Flow in Capillary Columns
Researchers have utilized wall-catalyzed segmented flow to overcome monitoring and yield problems.
Ask the Experts: The Challenges and Benefits of Flow Chemistry to Optimize Drug Development
In this article a variety of experts from within Medicinal Chemistry discuss key issues concerning the use of flow chemistry to optimize drug development.
A Quantitative Approach to Nucleophilic Organocatalysis
In this review article researchers demonstrate that important information can be obtained by specifically synthesizing relevant intermediates and studying the kinetics of their reactions with nucleophiles or electrophiles.
N-Heterocyclic Carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis
Cooperative catalysis is a powerful technique for the highly selective synthesis of a variety of target structures, in this commentary the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis will be highlighted.
Successful Scale-Up in the Production of CodeXol® Detergent Alcohols
Codexis and Chemtex achieve key milestone in commercial development of bio-based chemicals from non-food cellulosic biomass.
Almac Announces Further Expansion and 229 New Jobs
Dual expansion with completion of a new non-GMP drug development facility.
Novasep Appoints Fine Chemicals Market Director
Company strengthens its position by appointing Udo Steinhauer.
Codexis Appoints Vice President of Sales and Marketing
Appointment of Scott Watson as Vice President.
Nottingham Further Invest In Green Chemistry Laboratory
The School of Chemistry at the University of Nottingham (UK) has placed a sizeable order with Asynt to upgrade their undergraduate teaching facilities.
EMD Millipore and PharmaCell Announces Collaboration
Collaboration to evaluate EMD Millipore’s Mobius® bioreactor platform for expansion of HepaRG® cells.
Free Webinar Explores Safe Scaling of Pressure Reactions
Robust in situ technology allows cost effective scale-up pressure reactions.
Purdue Researcher's New 'Tool for the Organic Chemist Toolbox' Licensed to Sigma-Aldrich
U.S. patent for a safer, easier and "greener" method to incorporate fluorine into organic compounds has been licensed to a subsidiary of Sigma-Aldrich Corporation.
Halo Pharma Announces Investment and Formal Collaboration with Altus
Halo Pharma has taken a minority ownership position in, and established a formal collaboration with, Altus Formulation Inc.
Biotage and Peptide Synthesis
CEM claim to won a “patent dispute” with Biotage.
Codexis and Chemtex achieve key milestone in commercial development of bio-based chemicals from non-food cellulosic biomass.
Almac Announces Further Expansion and 229 New Jobs
Dual expansion with completion of a new non-GMP drug development facility.
Novasep Appoints Fine Chemicals Market Director
Company strengthens its position by appointing Udo Steinhauer.
Codexis Appoints Vice President of Sales and Marketing
Appointment of Scott Watson as Vice President.
Nottingham Further Invest In Green Chemistry Laboratory
The School of Chemistry at the University of Nottingham (UK) has placed a sizeable order with Asynt to upgrade their undergraduate teaching facilities.
EMD Millipore and PharmaCell Announces Collaboration
Collaboration to evaluate EMD Millipore’s Mobius® bioreactor platform for expansion of HepaRG® cells.
Free Webinar Explores Safe Scaling of Pressure Reactions
Robust in situ technology allows cost effective scale-up pressure reactions.
Purdue Researcher's New 'Tool for the Organic Chemist Toolbox' Licensed to Sigma-Aldrich
U.S. patent for a safer, easier and "greener" method to incorporate fluorine into organic compounds has been licensed to a subsidiary of Sigma-Aldrich Corporation.
Halo Pharma Announces Investment and Formal Collaboration with Altus
Halo Pharma has taken a minority ownership position in, and established a formal collaboration with, Altus Formulation Inc.
Biotage and Peptide Synthesis
CEM claim to won a “patent dispute” with Biotage.
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Concentration and Mixing Effects on the Production of Amine Hydrochloride Salts in a Confined Impinging Jet Reactor
University of Alberta
Results show that different AHC salts can be formed under different process conditions.
"Some Like it Hot" - Continuous Flow Chemistry at High Temperatures and Pressures
University of Graz
More and more recently published chemistry examples in glass-chip- and Teflon based microreactors begin to exploit the possibility of superheating solvents for process intensification leading to drastically shortened reaction times.
Quality Standards for 14C API for use in human clinical studies
Quotient Bioresearch
The Good Manufacturing Practice (GMP) state that the active pharmaceutical ingredient (API) intended for use in early stage clinical trials should be of "suitable" quality. The Clinic Ready quality standard ensures that the API is synthesised with all the appropriate documentation to facilitate QP release of the final IMP for guman clinical dosing.
Microwave chemistry in SiC Reaction Vials
University of Graz
Using novel SiC-technology to mimic conventional heated autoclave experiments.
Organic azide synthesis in microreactors: from optimization to lab scale production
Radboud University
The formation of benzyl azide by diazotransfer to benzyl amine was screened and subsequently scaled up using continuous flow chemistry.
Automated Sample Pretreatment of Environmental
Dionex Corporation
Matrix elimination is a method of sample preparation that removes certain matrix species from a sample, typically by specifically binding matrix species to a solid phase. Interfering compounds can be removed before the analyte determination, thus improving the quality of results as well as lengthening the lifetime of consumables such as columns.
Five noncovalent peptidic ligands show different affinity rankings in solution and gas phase
Institute for Research in Biomedicine (IRB), Barcelona Science Park, University of Barcelona, Spain
Stability of noncovalent complexes of VEGF protein with 5 peptidic ligands is studied. Experiments were conducted in solution (NMR CSP, ITC) and in gas phase (CID TOF MS). Each ligand differs from others in chirality of one amino acid. It was shown, that trend of stability of the studied noncovalent complexes is reversed in the gas phase relatively to the solution. An explanation of this behavior is presented.
Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor
Federal University of São Carlos
An inadequate transfer of oxygen can lead to rapid changes in cell physiology, metabolism, and cell death. In this work, the KLa is evaluated in a Taylor vortex flow bioreactor and a mass transfer correlation is proposed. The experimental conditions employed were: rotational Reynolds number between 244 and 2928, airflow rates varying from 80 mL.min-1 to 550 mL.min-1 and used culture medium DMEM.
Hyperbaric Bioreactors use with Yarrowia Lipolytica Cultures: Cellular Adaptation to Hyperbaric Conditions
IBB-Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho, Braga, Portugal
In this work, a pressurized bioreactor was used for Y. lipolytica batch cultivation under increased air pressure from 1 bar to 6 bar. Cell growth was strongly enhanced by the pressure rise. The increase of oxygen availability caused the induction of the antioxidant enzyme SOD. The pre-growth of Y. lipolytica under increased pressure conditions did not affect the lipase production ability of the cells.
Adaptive control of glycerol & methanol feeding in recombinant Pichia pastoris cultures: Impact on antibody titre
CQFB/REQUIMTE and IBET/ITQB
Pichia pastoris processes for heterolougous protein expression are typically run in three phases: a batch phase, an exponential feeding fed-batch phase and a long oxygen transfer limitation (OTL) phase. The final protein titre is often limited by the oxygen availability in the OTL phase. Here a direct adaptive controller is designed for the OTL phase. The controller was validated in pilot P. pastoris cultivations expressing a single chain antibody fragment (ScFv). This work shows that the propos
University of Alberta
Results show that different AHC salts can be formed under different process conditions.
"Some Like it Hot" - Continuous Flow Chemistry at High Temperatures and Pressures
University of Graz
More and more recently published chemistry examples in glass-chip- and Teflon based microreactors begin to exploit the possibility of superheating solvents for process intensification leading to drastically shortened reaction times.
Quality Standards for 14C API for use in human clinical studies
Quotient Bioresearch
The Good Manufacturing Practice (GMP) state that the active pharmaceutical ingredient (API) intended for use in early stage clinical trials should be of "suitable" quality. The Clinic Ready quality standard ensures that the API is synthesised with all the appropriate documentation to facilitate QP release of the final IMP for guman clinical dosing.
Microwave chemistry in SiC Reaction Vials
University of Graz
Using novel SiC-technology to mimic conventional heated autoclave experiments.
Organic azide synthesis in microreactors: from optimization to lab scale production
Radboud University
The formation of benzyl azide by diazotransfer to benzyl amine was screened and subsequently scaled up using continuous flow chemistry.
Automated Sample Pretreatment of Environmental
Dionex Corporation
Matrix elimination is a method of sample preparation that removes certain matrix species from a sample, typically by specifically binding matrix species to a solid phase. Interfering compounds can be removed before the analyte determination, thus improving the quality of results as well as lengthening the lifetime of consumables such as columns.
Five noncovalent peptidic ligands show different affinity rankings in solution and gas phase
Institute for Research in Biomedicine (IRB), Barcelona Science Park, University of Barcelona, Spain
Stability of noncovalent complexes of VEGF protein with 5 peptidic ligands is studied. Experiments were conducted in solution (NMR CSP, ITC) and in gas phase (CID TOF MS). Each ligand differs from others in chirality of one amino acid. It was shown, that trend of stability of the studied noncovalent complexes is reversed in the gas phase relatively to the solution. An explanation of this behavior is presented.
Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor
Federal University of São Carlos
An inadequate transfer of oxygen can lead to rapid changes in cell physiology, metabolism, and cell death. In this work, the KLa is evaluated in a Taylor vortex flow bioreactor and a mass transfer correlation is proposed. The experimental conditions employed were: rotational Reynolds number between 244 and 2928, airflow rates varying from 80 mL.min-1 to 550 mL.min-1 and used culture medium DMEM.
Hyperbaric Bioreactors use with Yarrowia Lipolytica Cultures: Cellular Adaptation to Hyperbaric Conditions
IBB-Institute for Biotechnology and Bioengineering, Center of Biological Engineering, University of Minho, Braga, Portugal
In this work, a pressurized bioreactor was used for Y. lipolytica batch cultivation under increased air pressure from 1 bar to 6 bar. Cell growth was strongly enhanced by the pressure rise. The increase of oxygen availability caused the induction of the antioxidant enzyme SOD. The pre-growth of Y. lipolytica under increased pressure conditions did not affect the lipase production ability of the cells.
Adaptive control of glycerol & methanol feeding in recombinant Pichia pastoris cultures: Impact on antibody titre
CQFB/REQUIMTE and IBET/ITQB
Pichia pastoris processes for heterolougous protein expression are typically run in three phases: a batch phase, an exponential feeding fed-batch phase and a long oxygen transfer limitation (OTL) phase. The final protein titre is often limited by the oxygen availability in the OTL phase. Here a direct adaptive controller is designed for the OTL phase. The controller was validated in pilot P. pastoris cultivations expressing a single chain antibody fragment (ScFv). This work shows that the propos
Comparing HPCCC to RP-HPLC for Kilo Scale Purification of Spinetoram
Dynamic Extractions
Spinetoram is a semi-synthetic insecticide produced by Dow AgroSciences. HPCCC method improved the kilo scale separation. The aim is to purify both components to >97% purity. HPCCC method improved the kilo scale separation.
Simultaneously Reducing your API Cost of Goods and Carbon Footprint
Dynamic Extractions Ltd
High Performance Continuous Extraction Technology can improve manufacturing efficiency and increase the green credentials of a production facility. This service offering is a result of a 3 year industry funded project that was supported by both GSK and Pfizer. A toll refining offering allows access to the technique with minimal risk to the customer. Future on-site deployment of can be assessed for supply of equipment for on-site installation.
Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega
BMG Labtech
The Oris™ Cell Migration Assays from Platypus offer certain advantages over traditional migration assays. Especially the TriCoated kits enable the researcher to test the effect of different extracellular matrix components like Collagen I or Fibronectin on migration. In this application note we show the real-time monitoring of cell migration using a POLARstar Omega from BMG LABTECH equipped with a CO2 gas vented system.
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices
Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Examples of FRX Applications for Demonstration
Syrris Ltd
FRX as a product offers a wide range of applications in a number of areas. To try and increase the exposure of the product to a wider audience, two standard demonstrations are detailed here. The first is a Wittig reaction showing the operation of an FRX200 system. The second is a separation of water and ethyl acetate demonstrating the operation of the FLLEX (Flow Liquid Liquid EXtraction module), for FRX300 or FRX400.
Cleaning Microreactors
Syrris Ltd
This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
The Basics of Flow Chemistry
Syrris Ltd
This application note gives information on the basics of flow chemistry, with particular reference to the FRX system.
Planning Successful Reactions
Syrris Ltd
This application note gives hints and tips for planning successful FRX reactions.
Superheating Reactions
Syrris Ltd
When using the Pressurisation Module, the FRX system can be easily pressurised up to 7bar. This allows reactions to be performed at temperatures much higher than atmospheric reflux, enabling faster and often cleaner, higher yielding reactions. This application note describes the practicalities of superheating reactions and the suggested maximum temperatures for common solvents.
Reaction Optimisation and Large Scale Synthesis
Syrris Ltd
A major benefit of flow chemistry is the ease and consistency of reaction scale up. In a flow reactor, high quality, reproducible mixing, excellent temperature control and superheating are maintained when increasing reaction volume.
Dynamic Extractions
Spinetoram is a semi-synthetic insecticide produced by Dow AgroSciences. HPCCC method improved the kilo scale separation. The aim is to purify both components to >97% purity. HPCCC method improved the kilo scale separation.
Simultaneously Reducing your API Cost of Goods and Carbon Footprint
Dynamic Extractions Ltd
High Performance Continuous Extraction Technology can improve manufacturing efficiency and increase the green credentials of a production facility. This service offering is a result of a 3 year industry funded project that was supported by both GSK and Pfizer. A toll refining offering allows access to the technique with minimal risk to the customer. Future on-site deployment of can be assessed for supply of equipment for on-site installation.
Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega
BMG Labtech
The Oris™ Cell Migration Assays from Platypus offer certain advantages over traditional migration assays. Especially the TriCoated kits enable the researcher to test the effect of different extracellular matrix components like Collagen I or Fibronectin on migration. In this application note we show the real-time monitoring of cell migration using a POLARstar Omega from BMG LABTECH equipped with a CO2 gas vented system.
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices
Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Examples of FRX Applications for Demonstration
Syrris Ltd
FRX as a product offers a wide range of applications in a number of areas. To try and increase the exposure of the product to a wider audience, two standard demonstrations are detailed here. The first is a Wittig reaction showing the operation of an FRX200 system. The second is a separation of water and ethyl acetate demonstrating the operation of the FLLEX (Flow Liquid Liquid EXtraction module), for FRX300 or FRX400.
Cleaning Microreactors
Syrris Ltd
This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
The Basics of Flow Chemistry
Syrris Ltd
This application note gives information on the basics of flow chemistry, with particular reference to the FRX system.
Planning Successful Reactions
Syrris Ltd
This application note gives hints and tips for planning successful FRX reactions.
Superheating Reactions
Syrris Ltd
When using the Pressurisation Module, the FRX system can be easily pressurised up to 7bar. This allows reactions to be performed at temperatures much higher than atmospheric reflux, enabling faster and often cleaner, higher yielding reactions. This application note describes the practicalities of superheating reactions and the suggested maximum temperatures for common solvents.
Reaction Optimisation and Large Scale Synthesis
Syrris Ltd
A major benefit of flow chemistry is the ease and consistency of reaction scale up. In a flow reactor, high quality, reproducible mixing, excellent temperature control and superheating are maintained when increasing reaction volume.
