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Wednesday, April 23, 2014
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LabTube Meets David Patteson, Advion...
Functional Monoliths for Flow Processes ...Continuous Flow Processing for Bioanalys...Meet the Freedom Rocker...

Featured Products
Featured Product - Carousel 12 Plus
Carousel 12 Plus
Featured Product - FlowSyn™ Maxi from Uniqsis – Scaling up your flow chemistry experiments has never been easier!
FlowSyn™ Maxi from Uniqsis – Scaling up your flow chemistry experiments has never been easier!

Webcasts
Webcast - Continuous Flow Reactors for Gas/Liquid Chemical ProcessesContinuous Flow Reactors for Gas/Liquid Chemical Processes
Graham Sandford, Professor, Durham University, speaking at Flow Chemistry Congress.
Webcast - Continuous Flow Multi-Step Organic Synthesis - Methods and ApplicationsContinuous Flow Multi-Step Organic Synthesis - Methods and Applications
Tim Jamison, Professor at Massachusetts Institute of Technology, speaking at Flow Chemistry Congress.

Market Reports
Flow Chemistry Market by Reactor Type, Application & Geography - Trends & Forecast to 2018
MarketsandMarkets

This report Flow Chemistry Market is segmented by type of reactor with major focus on micro reactor systems. The micro reactor system market is further segmented by type along with geography and applications.
Glucosamine
RI Technologies

The report serves as a guide to glucosamine industry covering more than 240 companies that are engaged in glucosamine R&D, processing, production, and distribution.
Chiral Chemicals
RI Technologies

This report focuses on the different methods and applications of Chiral Chemicals and their impact. The study provides global market analysis for preparation of chiral chemicals by traditional, asymmetric and biological methodologies.
Active Pharmaceutical Ingredients (API) Global Market to 2017 - Growth in Developing Markets to Come From Cost Efficient Manufacturing and Rising Domestic Demand
Global Data

GBI Research's report, “Active Pharmaceutical Ingredients (API) Global Market to 2017 - Growth in Developing Markets to Come From Cost Efficient Manufacturing and Rising Domestic Demand” provides detailed insight into the global APIs market. The research presents detailed analysis and forecasts of the major economic and market trends affecting the global APIs market.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Scientific News
Lab Scale Manufacturing Using Continuous Crystallization
A new METTLER TOLEDO On-demand webinar explores recent research that could revolutionize pharmaceutical production.
MIT Chemists Devise Novel Way to Manufacture Peptide Drugs
New, fast synthetic method enables manufacture of peptides in hours, which could boost drug development.
The Future Of Photochemistry
The Vapourtec UV-150 offers potential routes for novel compounds and building blocks together with possible new manufacturing processes.
Continuous-Flow Heck Synthesis of 4-Methoxybiphenyl and Methyl 4-Methoxycinnamate in scCO2 Expanded Solvent Solutions
This paper reports the Heck reaction between 4-iodoanisole and either styrene or methyl acrylate in a continuous flow reactor.
Silica: An Efficient Catalyst for One-Pot Regioselective Synthesis of Dithioethers
Researchers demonstrate that the choice of silica gel, either dry or moistened, could lead to highly selective pathways for the preparation of different dithioethers.
Flow Synthesis of Phenylserine using Threonine Aldolase Immobilized on Eupergit Support
Researchers from Eindhoven University of Technology have made the first step towards a critical view on the commercial potential for high-priced pharmaceutical products using enzymatic microreactor technology.
One-Step Synthesis of Pyridines and Dihydropyridines in a Continuous Flow Microwave Reactor
Microwave-assisted synthesis has revolutionized many processes in recent years as a valuable alternative to the use of conductive heating.
Chemical Synthesis: A Simple Technique for Highly Functionalized Compounds
Researchers at Kanazawa University have demonstrated a technique that allows direct functionalization of alkenes without the need for metallic reagents, photolysis or extreme reaction conditions.
Controlled Synthesis of Poly(3-hexylthiophene) in Continuous Flow
Continuous-flow synthesis methods offer several advantages over traditional batch methods.
Vapourtec Pump Key to Organometallic Process
Paper describes a telescoped continuous flow process that produces breast cancer drug Tamoxifen at the rate of one dose every 5 seconds.
Business News
Parker Domnick Hunter Enters Exclusive Partnership with BioPharma Dynamics
Partnership grants BioPharma Dynamics exclusive rights to distribute SciLog products.
Immutep and Eddingpharm Start Production of ImmuFact® IMP321
WuXi AppTec will manufacture ImmuFact® IMP321 to US, European and Chinese GMP standards for Immutep and Eddingpharm.
LGC Launches New Service for Stability Testing
New service enables continuous recording and monitoring of essential data.
Aesica Led Consortium Wins Technology Strategy Board Grant
Funding secured for the consortium’s project to investigate an industrial biotechnology process to enable improved manufacture of an API.
Goodwin Biotechnology, Aspyrian Therapeutics Collaborate on Innovative Antibody Drug Conjugate
The agreement is for the technology transfer, process development, scale - up, and cGMP manufacturing of a novel Antibody Drug Conjugate (ADC) for use in Phase I clinical trials.
Catalent Increases Stake in Redwood Bioscience
The increase follows compelling data generated by the SMARTag™ ADC platform.
Industry-Sponsored Academic Inventions Spur Increased Innovation
Analysis questions assumption that corporate support skews science toward inventions that are less useful than those funded by the government or non-profit organizations.
Alvotech and Finesse Announce Exciting Bio-Manufacturing Collaboration
Partnership will leverage Finesse’s SmartFactory single-use automation platform.
Horizon Pharma, Vidara Therapeutics International Ltd Acquisition to Become Horizon Pharma plc
The acquisition accelerates Horizon's transformation to a profitable specialty pharma company.
Mallinckrodt plc Completes $1.4 Billion Acquisition of Cadence Pharmaceuticals, Inc.
The acquision provides the Company with an expanded presence in the U.S. hospital channel.

Events
4th CMO Quality Oversight & Ri
23 Apr 2014
4th CMO Quality Oversight & Ri ...
More information
BIT
26 Apr 2014
BIT's 5th World Bio EXPO  (Bio ...
More information
13th Annual Biological Product
12 May 2014
13th Annual Biological Product ...
More information
HPAPI Development & Manufactur
28 May 2014
HPAPI Development & Manufactur ...
More information

ePosters
Microwave Assisted Green Synthesis of Aspirin From Over The Counter Pain Creams
Division of Natural Science, Mount Saint Mary College, NY

A successful microwave synthesis of methyl salicylate to aspirin using green catalysts from over the counter pain creams. The process was also prepared and tested in an undergraduate organic chemistry lab.
Functional Monoliths for Flow Processes by RAFT Polymerisation
CSIRO MATERIALS SCIENCE & ENGINEERING

Polymeric monoliths have recently emerged as a new class of solid supports for stoichiometric and catalytic reactions in continuous flow synthesis.
Marking of Weighing Equipment for Hazardous Areas
Mettler Toledo

This poster outlines typical markings for hazardous areas.
Recycled Gas Flow Control to Optimize Reaction Conversion and the Accomplishment of Heat Integration in Benzene Production through Hydrodealkylation of Toluene
ETH Zurich

In this work, a benzene production plant through hydrodealkylation process was investigated through a simulation by Aspen Plus V7.2® and run based on the real data obtained from a benzene production plant operating in the United States.
Recycled Gas Flow Control to Optimize Reaction Conversion and the Accomplishment of Heat Integration in Benzene Production through Hydrodealkylation of Toluene
ETH Zurich

In this work, a benzene production plant through hydrodealkylation process was investigated through a simulation by Aspen Plus V7.2® and run based on the real data obtained from a benzene production plant operating in the United States.
Marking of Weighing Equipment for Hazardous Areas
Mettler Toledo

This poster outlines typical markings for hazardous areas.
Concentration and Mixing Effects on the Production of Amine Hydrochloride Salts in a Confined Impinging Jet Reactor
University of Alberta

Results show that different AHC salts can be formed under different process conditions.
A mix-and-read cell-based assay for antibody screening against Epithelial Growth Factor Receptor
TTP Labtech

Here we present a sensitive robust, mix-and-read method for the screening of antibodies against cell surface proteins. With its simple operation, no-wash format, and high sensitivity, this new method is well-suited for high throughput antibody screening.
"Some Like it Hot" - Continuous Flow Chemistry at High Temperatures and Pressures
University of Graz

More and more recently published chemistry examples in glass-chip- and Teflon based microreactors begin to exploit the possibility of superheating solvents for process intensification leading to drastically shortened reaction times.
Quality Standards for 14C API for use in human clinical studies
Quotient Bioresearch

The Good Manufacturing Practice (GMP) state that the active pharmaceutical ingredient (API) intended for use in early stage clinical trials should be of "suitable" quality. The Clinic Ready quality standard ensures that the API is synthesised with all the appropriate documentation to facilitate QP release of the final IMP for guman clinical dosing.
Application Notes
Comparing HPCCC to RP-HPLC for Kilo Scale Purification of Spinetoram
Dynamic Extractions

Spinetoram is a semi-synthetic insecticide produced by Dow AgroSciences. HPCCC method improved the kilo scale separation. The aim is to purify both components to >97% purity. HPCCC method improved the kilo scale separation.
Simultaneously Reducing your API Cost of Goods and Carbon Footprint
Dynamic Extractions Ltd

High Performance Continuous Extraction Technology can improve manufacturing efficiency and increase the green credentials of a production facility. This service offering is a result of a 3 year industry funded project that was supported by both GSK and Pfizer. A toll refining offering allows access to the technique with minimal risk to the customer. Future on-site deployment of can be assessed for supply of equipment for on-site installation.
Analysis of migration using the OrisTM Cell Migration Assay-TriCoated kit on the POLARstar Omega
BMG Labtech

The Oris™ Cell Migration Assays from Platypus offer certain advantages over traditional migration assays. Especially the TriCoated kits enable the researcher to test the effect of different extracellular matrix components like Collagen I or Fibronectin on migration. In this application note we show the real-time monitoring of cell migration using a POLARstar Omega from BMG LABTECH equipped with a CO2 gas vented system.
Microplate-Based Endotoxin Testing in GLP/GMP Environments with the VersaMax™ Absorbance Microplate Reader and Pyrochrome® Assay
Molecular Devices

Monitoring for contaminants is a critical step during the production process in the pharmaceutical and medical device industries. A frequent contaminant, endotoxin, can cause fever, inflammation, headache, nausea, and even death. Found in the cell wall of gram negative bacteria, endotoxin has routinely been detected by the sensitive and specific Limulus Amebocyte Lysate (LAL) assay. In the presence of endotoxins, LAL coagulates through an enzyme-mediated cascade, which has then been traditional
Examples of FRX Applications for Demonstration
Syrris Ltd

FRX as a product offers a wide range of applications in a number of areas. To try and increase the exposure of the product to a wider audience, two standard demonstrations are detailed here. The first is a Wittig reaction showing the operation of an FRX200 system. The second is a separation of water and ethyl acetate demonstrating the operation of the FLLEX (Flow Liquid Liquid EXtraction module), for FRX300 or FRX400.
Cleaning Microreactors
Syrris Ltd

This application note gives hints and tips on cleaning & unblocking flow reactors, i.e. chips or tube based reactors. It is suggested that the whole document is read before attempting to unblock a reactor.
The Basics of Flow Chemistry
Syrris Ltd

This application note gives information on the basics of flow chemistry, with particular reference to the FRX system.
Planning Successful Reactions
Syrris Ltd

This application note gives hints and tips for planning successful FRX reactions.
Superheating Reactions
Syrris Ltd

When using the Pressurisation Module, the FRX system can be easily pressurised up to 7bar. This allows reactions to be performed at temperatures much higher than atmospheric reflux, enabling faster and often cleaner, higher yielding reactions. This application note describes the practicalities of superheating reactions and the suggested maximum temperatures for common solvents.
Reaction Optimisation and Large Scale Synthesis
Syrris Ltd

A major benefit of flow chemistry is the ease and consistency of reaction scale up. In a flow reactor, high quality, reproducible mixing, excellent temperature control and superheating are maintained when increasing reaction volume.
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