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Continuous-Flow Catalytic Asymmetric Hydrogenations: Reaction Optimization Using FTIR Inline Analysis

Published: Tuesday, April 17, 2012
Last Updated: Tuesday, April 17, 2012
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Researchers from RWTH Aachen University have coupled a ReactIR flow cell with the microreactor and applied as an inline monitoring device for optimizing the reactions.

Abstract
The asymmetric organocatalytic hydrogenation of benzoxazines, quinolines, quinoxalines and 3H-indoles in continuous-flow microreactors has been developed. Reaction monitoring was achieved by using an inline ReactIR flow cell, which allows fast and convenient optimization of reaction parameters. The reductions proceeded well, and the desired products were isolated in high yields and with excellent enantioselectivities.

The article is published online in Beilstein Journal of Organic Chemistry and is free to access.


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