Corporate Banner
Satellite Banner
Chemical Process Scale Up
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Codexis Selected for Third Presidential Green Chemistry Award in Seven Years

Published: Tuesday, June 19, 2012
Last Updated: Tuesday, June 19, 2012
Bookmark and Share
The award, from the U.S. Environmental Protection Agency, is for the development of an efficient biocatalytic process to manufacture simvastatin, a leading drug for treating high cholesterol.

This marks the third time in seven years that Codexis has been honored with this award; Codexis was a recipient in 2006 and 2010.

Simvastatin is the most prescribed statin in the U.S., with 94.1 million prescriptions in 2010 according to IMS Health. Traditionally, synthesis of simvastatin has required an inefficient, multistep chemical process that involves significant quantities of hazardous reagents. In collaboration with Professor Yi Tang at the University of California, Los Angeles, Codexis conceived and developed a synthesis using an engineered enzyme and a practical, low-cost feedstock. Codexis optimized both the enzyme and the chemical process for the large-scale, commercial manufacture of simvastatin. The resulting process produces high quality simvastatin in a cost–effective manner and greatly reduces the use of hazardous chemicals and the amount of waste produced.

“Collaborating with the Codexis team was a true inspiration. Their directed evolution technology empowered us to go beyond academic theory and deliver a more environmentally friendly process that is impacting the pharmaceutical industry today,” said Yi Tang, Professor, University of California Los Angeles.

“Green chemistry and Codexis’ CodeEvolver™ directed evolution technology represent the future of cleaner, more efficient, and cost-advantaged pharmaceutical manufacturing processes. With the help of Professor Tang and his team, this award confirms Codexis’ role as an industry leader, and we are honored to be recognized for a third time by the U.S. Environmental Protection Agency (EPA) for our achievements,” said Gjalt Huisman, Ph.D., Vice President of Product Planning, Pharmaceuticals at Codexis.

The process was scaled up at Codexis’ longstanding collaborator, Arch Pharmalabs Ltd., in Mumbai, India. Arch Pharmalabs manufactures a number of products for Codexis, including the 2006 Presidential Green Chemistry Challenge Award-winning process for atorvastatin, the active ingredient in Pfizer’s Lipitor®.

“We are running six biocatalytic processes developed by Codexis and have shown that they are reliably scalable and comparable to chemical processes, while offering significant advantages in terms of product purity, reduced waste, and reduced energy consumption,” said Dr. Ganesh Pai, Director of Research and Development, Arch Pharmalabs Ltd.

Codexis is the first and, to date, only company to have won the Presidential Green Chemistry Challenge Award in both the small business and open categories. In 2010, in collaboration with Merck, Codexis won a previous Green Chemistry award for the development of a novel biocatalytic method for the synthesis of sitagliptin, the active pharmaceutical ingredient in Merck's Januvia®. And in 2006, as a small business with less than $40 million in annual sales, Codexis was similarly honored for developing three enzymes used to produce the key chiral building block for atorvostatin.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Codexis Sells its Hungarian Operations
The Hungarian subsidiary is sold for $1.5 million to Intrexon Corporation.
Friday, March 14, 2014
Codexis Appoints Patrick Yang to Board of Directors
Dr. Yang brings significant experience in pharmaceutical manufacturing and process development.
Friday, February 28, 2014
Successful Scale-Up in the Production of CodeXol® Detergent Alcohols
Codexis and Chemtex achieve key milestone in commercial development of bio-based chemicals from non-food cellulosic biomass.
Tuesday, June 18, 2013
Codexis Appoints Vice President of Sales and Marketing
Appointment of Scott Watson as Vice President.
Thursday, June 06, 2013
Scientific News
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
New Cancer Fighters Emerge From Lab
Rice University lab simplifies total synthesis of anti-cancer agent.
Pharmacy on Demand
New, portable system can be configured to produce different drugs.
Safer, Cheaper, Greener and More Efficient System for Organic Synthesis
The new medium not only supports organic synthesis it also produces considerably higher yields of product than pure organic solvents.
Countless New, Cleaner Uses of Methane
Chemists have demonstrated the potential to use methane as a versatile chemical building block with which to make more complex molecules.
New Way to Control Chemical Reactions
Scientists have harnessed static electricity to control chemical reactions for the first time, in a breakthrough that could bring cleaner industry and cheaper nanotechnology.
Tiny 'Flasks' Speed Up Chemical Reactions
Self-assembling nanosphere clusters may improve everything from drug synthesis to drug delivery.
The Manufacturing Challenges of Nanotechnology
Head of NanoManufacturing at the Department of Engineering’s Institute for Manufacturing (IfM) Dr Michaël de Volder explains why manufacturing carbon nanotubes is so difficult – and so important.
New Material Lays Waste to Mercury Pollution
A brand new, dirt cheap, non-toxic polymer that literally sucks mercury out of water and soil is set to become a game changer in the battle against one of the world’s most reviled pollutants.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!