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N-Heterocyclic Carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis

Published: Saturday, August 25, 2012
Last Updated: Tuesday, August 21, 2012
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Cooperative catalysis is a powerful technique for the highly selective synthesis of a variety of target structures, in this commentary the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis will be highlighted.

Abstract
The interplay between metals and N-heterocyclic carbenes (NHCs) has provided a window of opportunities for the development of novel catalytic strategies within the past few years. The recent successful combination of Brønsted acids with NHCs has added a new dimension to the field of cooperative catalysis, enabling the stereoselective synthesis of functionalized pyrrolidin-2-ones as valuable scaffolds in heterocyclic chemistry. This Commentary will briefly highlight the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis as a new and powerful methodology in organic chemistry.

The article is published online in Beilsten Journal of Organic Chemistry and is free to access.


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