Corporate Banner
Satellite Banner
Chemical Process Scale Up
Scientific Community
Become a Member | Sign in
Home>News>This Article

Melbourn Scientific Announces First Nasal Device Testing Lab at ICSE

Published: Thursday, September 20, 2012
Last Updated: Wednesday, September 19, 2012
Bookmark and Share
Service offers GMP analysis of droplet size, particle characterization, spray pattern and plume geometry.

The multiple benefits of a nasal spray has triggered a boom in product development activity generating greater demand for Melbourn Scientific’s expertise in formulation analysis and performance testing.

In response the company has created a dedicated laboratory to provide GMP testing of nasal device performance, the first in Europe to offer such a comprehensive service.

Mark Hammond, CEO of Melbourn Scientific says: “We predicted a few years ago that nasal delivery of compounds would increase as companies realized the benefits of this route. A nasal device offers a user friendly, painless, non-invasive route for drug administration.

“We are now seeing evidence of continued growth and that clients recognize the advantages of working with partners that have expertise in this area of drug delivery and understand the formulation and analytical challenges that it brings.

The portfolio of nasal spray services offered by Melbourn includes: nasal device performance testing, droplet size and distribution analysis, spray pattern and plume geometry analysis.

The new laboratory was included within a recent FDA inspection, which the company passed with ‘no significant deficiencies noted and no 483s issued’.

“The high surface area in the nasal cavity provides drugs with direct access to the systemic circulation providing rapid onset of action. This route also avoids any degradation from first pass metabolism, which means lower doses can be given reducing the possibility of unwanted side effects.”

The nasal cavity has a large surface area and high permeability, and the location of lymphoid tissue at the back of the nasal cavity offers rapid transport into the systemic circulation.

The olfactory region at the top of the nasal cavity is of interest for the treatment for age-associated diseases such as Alzheimer’s, as it allows rapid absorption into the central nervous system.

The nasal route can also enhance performance for a wide range of treatments from the instant relief of panic attacks through to needle-free vaccinations.

However, the challenge of a nasal delivery device is to get the particle size right in order to ensure that the drug is deposited within the nasal passages and not the lungs or gastro-intestinal tract. This is where a comprehensive testing regime is beneficial.

Mark explains, “Depending upon the drug and device properties there are a number of considerations for the formulation, here at Melbourn Scientific we have developed a range of screening tools to enable us to fast track formulation development of the product from simple solutions, through suspensions to dry powder blends using a wide range of excipients.

“Our formulation development is supported by standalone testing services with significant investment in specialist equipment. The new lab will make this available as a comprehensive service.”

Equipment includes: the Malvern Spraytec, which is designed to capture information about both pulsed spray and continuous spray events, Morphologi G3 an optical imaging tool that provides more information about individual particles giving data about their size, shape and solidity and the new Proveris’s SprayVIEW, a FDA accepted spray pattern and plume geometry analysis service.

Melbourn Scientific has also appointed a new business development executive Liz Parkhouse to provide a point of contact for the nasal spray testing service. She will be at ICSE to talk to visitors.

Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,200+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
Cutting the Cost of Drug-Building Chemicals
EPFL scientists have developed a method to produce aryl-containing amines in a cheap and easily scalable way.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
Porphyrins as Catalysts in Scalable Organic Reactions
This review covers the most relevant scalable porphyrin-catalysed procedures, showing how these compounds represent broad applications in chemistry.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
New Cancer Fighters Emerge From Lab
Rice University lab simplifies total synthesis of anti-cancer agent.
Pharmacy on Demand
New, portable system can be configured to produce different drugs.
Countless New, Cleaner Uses of Methane
Chemists have demonstrated the potential to use methane as a versatile chemical building block with which to make more complex molecules.
Safer, Cheaper, Greener and More Efficient System for Organic Synthesis
The new medium not only supports organic synthesis it also produces considerably higher yields of product than pure organic solvents.

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,200+ scientific videos