Corporate Banner
Satellite Banner
Chemical Process Scale Up
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Merck Millipore Launches PDReady™ Monoclonal Antibodies Kit

Published: Tuesday, December 11, 2012
Last Updated: Tuesday, December 11, 2012
Bookmark and Share
Integrates small-scale purification devices, process development protocols and technical support for rapid and efficient downstream process development.

Merck Millipore has launched its PDReady™ for Monoclonal Antibodies (MAbs) Kit for accelerating process development timelines.

The kit is based on a robust process development template using technologies for each purification operation.

Every step within the template uses a technology already proven to successfully purify MAbs, allowing biopharmaceutical manufacturers to rapidly develop a reliable purification process that delivers high purity and yield.

The PDReady™ for MAbs Kit reduces the complexity of process development by providing a single integrated package including purification devices, precise protocols to guide process development, specific recommendations for required laboratory tools, support from Merck Millipore technical experts, and equipment such as the Cogent® µScale that is loaned to the customer.

Each unit operation within the template is designed for convenient scaling from bench to clinic. By employing a proven template for MAb purification, the necessary experimentation for process development is drastically reduced, saving time, money and effort, while still developing a robust process.

"The PDReady™ for MAbs Kit leverages Merck Millipore's proven technologies to deliver a template for rapid and efficient downstream process development," said Vin Donovan, Vice President of Biopharm Process Solutions.

Donovan continued, "Our experience with these technologies in monoclonal antibody processes allows us to establish known process parameters, drastically reducing the experimentation required to achieve drug purity and yield targets. This speeds the time to clinic and ultimately commercial-scale production."

Purification unit operations within the PDReady™ for MAbs Kit include:
• Clarification - Millistak+® Pod Filter System
- Robust clarification in an easy-to-use format
• Affinity Chromatography - ProSep® Media
- Designed for cost-effective purification of high titer therapeutic antibodies
• Cation Exchange Chromatography - Fractogel® Media
- Provides reliability with optimal yields and efficient purification
• Anion Exchange Chromatography - ChromaSorb™ Membrane Absorber
- Provides the greatest levels of impurity binding at the highest salt concentrations for monoclonal antibodies
• Virus Filtration - Viresolve® Filters
- Robustly retains viruses while ensuring maximum product recovery
• Ultrafiltration - Pellicon® 3 Cassettes
- Tangential flow filtration device of choice for demanding filtration processes, including higher operating pressures, temperatures and caustic cleaning regimes
• Sterile Filtration (including buffers) - Millipore Express® Filters
- Provides sterility assurance, broad chemical compatibility, high flow rates and exceptionally high capacity
• Cogent® µScale TFF System
- Easy-to-use, semi-automated bench top TFF system for micro-scale process development and everyday low-volume ultrafiltration/diafilitration


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Merck Millipore Invests €12M in France Facility
The investments will expand ready-to-use media manufacturing at company's Molshiem facility.
Tuesday, August 12, 2014
Merck Millipore Announces Opening of its GMP Bioproduction Facility in France
Enables accelerated process development and production of proteins/monoclonal antibodies.
Friday, September 21, 2012
Scientific News
Solvent-free, Catalyst-free Peracetylation of Natural Products
In this study, a tunable microwave-assisted method for the solvent-free and catalyst-free peracetylation of natural products was developed.
Sonochemical Reactors
A critical analysis of the underlying mechanisms for intensification, available reactor configurations and overview of the different applications exploited successfully are presented.
Economical and Scalable Synthesis of 6-amino-2-cyanobenzothiazole
An economical and scalable synthesis of ACBT is presented, along with advantages for scale-up over previously reported routes.
Peer Review is in Crisis, But Should be Fixed, Not Abolished
After the time to get the science done, peer review has become the slowest step in the process of sharing studies, and some scientists have had enough.
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
Cutting the Cost of Drug-Building Chemicals
EPFL scientists have developed a method to produce aryl-containing amines in a cheap and easily scalable way.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
Porphyrins as Catalysts in Scalable Organic Reactions
This review covers the most relevant scalable porphyrin-catalysed procedures, showing how these compounds represent broad applications in chemistry.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!