Mettler Toledo has launched the latest installment in its ongoing Recent Advances in Organic Chemistry webinar series.
In it, Mettler Toledo technology and applications specialist Dominique Hebrault, PhD. reviews several recent experiments-both published, and yet-to-be published-in which mid-infrared spectroscopy, or mid-IR, enabled efficient continuous flow chemistry processes.
In each case, inline monitoring combined with an integrated flow system was shown to offer significant time savings over traditional methods when performing critical reaction optimization studies.
Each case study focuses on a different aspect of flow chemistry that has historically proven challenging for chemists and engineers.
These include the Vilsmeier-Haack formylation of unstable intermediates; high-pressure gas/liquid homogenous catalysis; Paal-Knorr synthetic transformation using a microreactor; and continuous asymmetric hydrogenation of benzoxazines, quinolones, quinoxalines and 3H-indoles with Hantzsch dihydropyridine.
Dr. Hebrault provides step-by-step analysis of each, summarizing how ReactIR™ and flow chemistry, when used together, offers researchers more in-depth reaction understanding that would have been difficult or even impossible to gain using traditional methods.
The webinar is the second such Mettler Toledo presentation dedicated to flow chemistry and continuous processing and the eighth to explore mid-IR in the form of its own ReactIR™ system as a key analytical technology.
In flow chemistry, mid-IR’s ability to highlight structures with a high degree of specificity in real time and provide important data on parameters such as absorbance and steady state that guide optimization Is key for today’s researchers.
This feedback helps ensure batch reactions are safe, repeatable and efficient, making the pairing of flow chemistry and mid-IR a natural one.