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Tuesday, September 23, 2014
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Concentration and Mixing Effects on the Production of Amine Hydrochloride Salts in a Confined Impinging Jet Reactor
Navid F. Ershad, Archie Eaglesham, Don H. Jones and Suzanne M. Kresta

Results show that different AHC salts can be formed under different process conditions.

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A mix-and-read cell-based assay for antibody screening against Epithelial Growth Factor Receptor
Wayne P Bowen, David Onley, Paul Wylie, Diana Caracino and Tristan Cope

Here we present a sensitive robust, mix-and-read method for the screening of antibodies against cell surface proteins. With its simple operation, no-wash format, and high sensitivity, this new method is well-suited for high throughput antibody screening.

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"Some Like it Hot" - Continuous Flow Chemistry at High Temperatures and Pressures
David Obermayer, Bernhard Gutmann, Toma N. Glasnov, Tahseen Razzaq, Markus Damm and C. Oliver Kappe

More and more recently published chemistry examples in glass-chip- and Teflon based microreactors begin to exploit the possibility of superheating solvents for process intensification leading to drastically shortened reaction times.

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Quality Standards for 14C API for use in human clinical studies
I Shaw, G Johnston, K Dare, D Dams

The Good Manufacturing Practice (GMP) state that the active pharmaceutical ingredient (API) intended for use in early stage clinical trials should be of "suitable" quality. The Clinic Ready quality standard ensures that the API is synthesised with all the appropriate documentation to facilitate QP release of the final IMP for guman clinical dosing.

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Microwave chemistry in SiC Reaction Vials
D. Obermayer, B. Gutmann, B. Reichart, C. O. Kappe

Using novel SiC-technology to mimic conventional heated autoclave experiments.

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Organic azide synthesis in microreactors: from optimization to lab scale production
Pieter J. Nieuwland, Bo Hanssen, Kaspar Koch, Paul Janssen, Marielle M.E. Delville, Anton Lunshof and Floris P.J.T. Rutjes

The formation of benzyl azide by diazotransfer to benzyl amine was screened and subsequently scaled up using continuous flow chemistry.

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Automated Sample Pretreatment of Environmental
Bernard Sheldon,1 Rosanne Slingsby,1 and Rida Al-Horr2

Matrix elimination is a method of sample preparation that removes certain matrix species from a sample, typically by specifically binding matrix species to a solid phase. Interfering compounds can be removed before the analyte determination, thus improving the quality of results as well as lengthening the lifetime of consumables such as columns.

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Five noncovalent peptidic ligands show different affinity rankings in solution and gas phase
Andrey Dyachenko , Michael Goldflam , Marta Vilaseca , Ernest Giralt

Stability of noncovalent complexes of VEGF protein with 5 peptidic ligands is studied. Experiments were conducted in solution (NMR CSP, ITC) and in gas phase (CID TOF MS). Each ligand differs from others in chirality of one amino acid. It was shown, that trend of stability of the studied noncovalent complexes is reversed in the gas phase relatively to the solution. An explanation of this behavior is presented.

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Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor
Patrícia Ap. Santiago, Cláudio A. T. Suazo, Roberto C. Giordano

An inadequate transfer of oxygen can lead to rapid changes in cell physiology, metabolism, and cell death. In this work, the KLa is evaluated in a Taylor vortex flow bioreactor and a mass transfer correlation is proposed. The experimental conditions employed were: rotational Reynolds number between 244 and 2928, airflow rates varying from 80 mL.min-1 to 550 mL.min-1 and used culture medium DMEM.

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Showing Results 11 - 20 of 58
Scientific News
Preparation of Phosphines Through C–P Bond Formation
This article reviews some of the most important C–P bond formation strategies, organizing them according to the hybridization of carbon in the newly formed C–P bond.
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
High Temperature Synthesis Using Heating Blocks
Asynt DrySyn MULTI heating block systems are being utilised to support ground breaking synthetic research in photovoltaics, water splitting and nanoimaging.
Lonely Bacteria are More Likely to Become Antibiotic-resistant
Scientists from the University of Manchester have discovered that microbes in smaller groups are more likely to mutate, resulting in higher rates of antibiotic resistance.
Lab Scale Manufacturing Using Continuous Crystallization
A new METTLER TOLEDO On-demand webinar explores recent research that could revolutionize pharmaceutical production.
MIT Chemists Devise Novel Way to Manufacture Peptide Drugs
New, fast synthetic method enables manufacture of peptides in hours, which could boost drug development.
The Future Of Photochemistry
The Vapourtec UV-150 offers potential routes for novel compounds and building blocks together with possible new manufacturing processes.
Continuous-Flow Heck Synthesis of 4-Methoxybiphenyl and Methyl 4-Methoxycinnamate in scCO2 Expanded Solvent Solutions
This paper reports the Heck reaction between 4-iodoanisole and either styrene or methyl acrylate in a continuous flow reactor.
Silica: An Efficient Catalyst for One-Pot Regioselective Synthesis of Dithioethers
Researchers demonstrate that the choice of silica gel, either dry or moistened, could lead to highly selective pathways for the preparation of different dithioethers.
Flow Synthesis of Phenylserine using Threonine Aldolase Immobilized on Eupergit Support
Researchers from Eindhoven University of Technology have made the first step towards a critical view on the commercial potential for high-priced pharmaceutical products using enzymatic microreactor technology.
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