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Novel Gpr39 Agonists: Correlation Of Binding Affinity Using Label-Free Back-Scattering Interferometry With Potency In Functional Assays
Daniel Brown (1), Niklas Larsson (2), Ola Fjellström (3), Anders Johansson (3), Sara Lundqvist (2), Johan Brengdahl (2), and Richard J. Isaacs (1)

We describe the application of back-scattering interferometry (BSI) to the characterization of small molecule ligand binding to human GPR39 (a GPCR targeted for type-2 diabetes therapy) overexpressed in crude membrane fractions in free solution, including how BSI-derived affinity and functional assay-derived potency correlate for compounds of varying scaffolds

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A Novel Approach Toward Microfluidic Drug Metabolite Synthesis – Electrosynthetic Methodology Simulating Cytochrome (CYP450) Oxidation
Romain Stalder, Gregory P. Roth and Philip Podmore

A novel microfluidic technology and electrochemical synthesis method is demonstrated for the efficient generation of known drug metabolites. These metabolites are typically generated on first pass hepatic oxidation in vivo. The FLUX Module, a new microfluidic electrochemical cell manufactured by Syrris Ltd., has been employed to generate the metabolites of five commercial drugs: Tolbutamide, Chlorpromazine, Diclofenac, Primidone and Albendazole.

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Microwave Assisted Green Synthesis of Aspirin From Over The Counter Pain Creams
Annie E. Dineen, Jodie T. Wasacz

A successful microwave synthesis of methyl salicylate to aspirin using green catalysts from over the counter pain creams. The process was also prepared and tested in an undergraduate organic chemistry lab.

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Functional Monoliths for Flow Processes by RAFT Polymerisation
Kristine J. Barlow, Victor Bernabeu, Xiaojuan Hao, Timothy C. Hughes, Oliver E. Hutt, Anastasios Polyzos, Kathleen A. Turner, Graeme Moad

Polymeric monoliths have recently emerged as a new class of solid supports for stoichiometric and catalytic reactions in continuous flow synthesis.

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Marking of Weighing Equipment for Hazardous Areas

This poster outlines typical markings for hazardous areas.

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Recycled Gas Flow Control to Optimize Reaction Conversion and the Accomplishment of Heat Integration in Benzene Production through Hydrodealkylation of Toluene

In this work, a benzene production plant through hydrodealkylation process was investigated through a simulation by Aspen Plus V7.2® and run based on the real data obtained from a benzene production plant operating in the United States.

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Recycled Gas Flow Control to Optimize Reaction Conversion and the Accomplishment of Heat Integration in Benzene Production through Hydrodealkylation of Toluene
Afshin Abrishamkar, Saman Ahmadi Siahpoush, Yury Avramenko, Eiman Rahnema Falavarjani

In this work, a benzene production plant through hydrodealkylation process was investigated through a simulation by Aspen Plus V7.2® and run based on the real data obtained from a benzene production plant operating in the United States.

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Marking of Weighing Equipment for Hazardous Areas
Mettler Toledo

This poster outlines typical markings for hazardous areas.

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Concentration and Mixing Effects on the Production of Amine Hydrochloride Salts in a Confined Impinging Jet Reactor
Navid F. Ershad, Archie Eaglesham, Don H. Jones and Suzanne M. Kresta

Results show that different AHC salts can be formed under different process conditions.

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Scientific News
Are Chemical Safety Regulations Changing Your Laboratory?
GHS changes to country chemical regulations affect everyone.
Continuous Flow of Breakthroughs for Vapourtec
Flow chemistry systems designed and manufactured by Vapourtec have recently reached the milestone of having been cited in 150 peer review publications.
A Continuous Flow System for the Measurement of Ambient Nitrogen Oxides
The proposed method can be used in industrial locations to continuously monitor ambient NOx levels and it can be automated for measuring the variation of NOx concentrations.
Accelerating Spirocyclic Polyketide Synthesis
Powerful flow chemistry techniques used for complex multi-stage synthesis of spirocyclic polyketides.
Syrris Atlas has the Midas Touch with Nanoparticles
Spanish biotechnology company Midatech Biogune is taking advantage of our Atlas Potassium reactor systems to produce custom-made functionalized gold nanoparticles for medicinal use.
Simple, Rapid and Effective Method for Ammonia Determination
Researchers have a developed a modern, miniaturized and economic flow system to overcome problems of using Nessler's reagent for ammonia determination.
Preparation of Phosphines Through C–P Bond Formation
This article reviews some of the most important C–P bond formation strategies, organizing them according to the hybridization of carbon in the newly formed C–P bond.
Catalysts That Mimic Enzymes Could Revolutionize Pharmaceutical Manufacturing
Structures made of polymer chains allow the catalysts to work in water.
High Temperature Synthesis Using Heating Blocks
Asynt DrySyn MULTI heating block systems are being utilised to support ground breaking synthetic research in photovoltaics, water splitting and nanoimaging.
Lonely Bacteria are More Likely to Become Antibiotic-resistant
Scientists from the University of Manchester have discovered that microbes in smaller groups are more likely to mutate, resulting in higher rates of antibiotic resistance.
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