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From Medicinal Plants to Bioactive Drugs
Ilaria Lampronti, Mahmud T.H. Khan, Antoine M. Saab, Elisabetta Lambert, Letizia Penolazzi, Roberta Piva and Roberto Gambari

The aim of our study was to analyze the antiproliferative activity effects on human tumor cell lines and the differentiating activity on human erythroleukemic K562 cells of different extracts derived from medicinal plants of Bangladesh and Lebanon.

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Development of an Analytical Data Management System (ADMS) to Accelerate the Selection of a Suitable API Form Through Salt and Polymorph Screening
Raeann Wu, Peter Karpinski, Patrick Drumm, Karim Kassam, Michel R.J. Hachey and Michael Boruta

In this work, we discuss the acceleration of the preformulation process through the use of modern software systems. The data system discussed can read, process, store, retrieve, visualize and report a wide variety of data type—XRD, Raman, HPLC, NMR, TGA, DSC, chemical structures, properties and images—in a centralized and homogeneous way. A pilot study at a pharmaceutical company demonstrated possible time savings between 20% and 80% at various points in the preformulation workflow.

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Exploring Reverse Transcription for DNA MicroArrays
Miroslava Cuperlovic-Culf, Adrian S. Culf, Dominique Richard, Mark LaFlamme, Daniel Leger and Rodney J. Ouellette

Results suggest that random priming is the optimal method for expression analysis of long genes. This method of RT may be appropriate for alternatively spliced genes and for genes without unique probes in the 3’-region.

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Protein Expression Profiling with High-Content Antibody Arrays using Universal Linkage System ULS™ Protein Labeling
Frank Opdam, Saskia Schoenmakers, Marie Lacombe, Sandra van der Locht, Alain van Gool and Paul van der Hoeven

The Universal Linkage System (ULS™) is a platinum-based technology that allows direct labeling of proteins and nucleic acids with a large variety of labels and haptens, including many fluorophores, biotin, and dinitrophenol.

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Carbon Nanotubes by Microwave Plasma Enhanced Chemical Vapor Deposition
M. Maschmann, A. Goyal, Z. Iqbal, T.S. Fisher, R. Gat

MICROWAVE Plasma generates radical density characteristic of 2000C at much lower effective temperature and can be highly ionized (Low pressure ECR mode) or highly neutral (high pressure mode).

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Metabonomics for MolPAGE Discovering Diabetes Biomarkers
K. Magnus Åberg, Mark Jairaj, Henrik Toft Pedersen, Dorrit Baunsgaard

MolPAGE (Molecular Phenotyping to Accelerate Genomic Epidemiology) is an EU consortium with almost twenty collaborating universities and companies throughout Europe. One of the aims of MolPAGE is to find early onset biomarkersfor type 2 diabetes (T2DM) and cardio-vascular diseases(CVD).

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Microwave-Accelerated Fischer Glycosidation
Laurent F. Bornaghi and Sally-Ann Poulsen

Fischer glycosidation appeared an ideal candidate for the application of microwave irradiation and herein we report a systematic analysis of the effect of microwave heating in the Fischer glycosidation reaction.

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Showing Results 41 - 47 of 47
Scientific News
Imperial College Employs Parallel Synthesis to Develop Better Catalysts
Asynt DrySyn MULTI and parallel synthesis kits to provide safer, more convenient way to perform heated catalytic reactions in parallel.
Antimalarial Drug Launched
Twelve years after a breakthrough discovery in his UC Berkeley laboratory, professor of chemical engineering Jay Keasling is seeing his dream come true.
From Bead to Flask: Synthesis of a Complex ß-amido-amide for Probe-Development Studies
This study reports the synthesis of LLW62, which is a complex benzimidazole-substituted ß-amido-amide similar in structure to inhibitors of p21 that were reported previously to support studies of this compound as a biological probe.
Simultaneous Saccharification and Co-Fermentation for Bioethanol Production at Lab, PDU and Demo Scales
In this study, researchers designed a SSCF process and scaled up from lab to demo scale reaching 4% (w/v) ethanol using xylose rich corncobs.
Mechanochemistry Assisted Asymmetric Organocatalysis: A Sustainable Approach
This review highlights the progress in asymmetric organocatalytic reactions assisted by mechanochemical techniques.
Flow Photochemistry: Old Light Through New Windows
This review highlights the use of flow reactors in organic photochemistry, allowing a comparison of the various reactor types to be made.
Heterogeneously Catalyzed Continuous-Flow Hydrogenation Using Segmented Flow in Capillary Columns
Researchers have utilized wall-catalyzed segmented flow to overcome monitoring and yield problems.
Ask the Experts: The Challenges and Benefits of Flow Chemistry to Optimize Drug Development
In this article a variety of experts from within Medicinal Chemistry discuss key issues concerning the use of flow chemistry to optimize drug development.
A Quantitative Approach to Nucleophilic Organocatalysis
In this review article researchers demonstrate that important information can be obtained by specifically synthesizing relevant intermediates and studying the kinetics of their reactions with nucleophiles or electrophiles.
N-Heterocyclic Carbene/Brønsted Acid Cooperative Catalysis as a Powerful Tool in Organic Synthesis
Cooperative catalysis is a powerful technique for the highly selective synthesis of a variety of target structures, in this commentary the concept of N-heterocyclic carbene/Brønsted acid cooperative catalysis will be highlighted.
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