|Application of Microarrays in Process Analytical Technologies A First Step Towards Real Time Product Release|
Streefland M, van de Waterbeemd B, vander Pol LA, Beuvery EC, Martens DE,Tramper J
Application of microarrays during process development helps to gain insight in biological processes involved in product formation, increasing process understanding.
|From Medicinal Plants to Bioactive Drugs|
Ilaria Lampronti, Mahmud T.H. Khan, Antoine M. Saab, Elisabetta Lambert, Letizia Penolazzi, Roberta Piva and Roberto Gambari
The aim of our study was to analyze the antiproliferative activity effects on human tumor cell lines and the differentiating activity on human erythroleukemic K562 cells of different extracts derived from medicinal plants of Bangladesh and Lebanon.
|Development of an Analytical Data Management System (ADMS) to Accelerate the Selection of a Suitable API Form Through Salt and Polymorph Screening|
Raeann Wu, Peter Karpinski, Patrick Drumm, Karim Kassam, Michel R.J. Hachey and Michael Boruta
In this work, we discuss the acceleration of the preformulation process through the use of modern software systems. The data system discussed can read, process, store, retrieve, visualize and report a wide variety of data type—XRD, Raman, HPLC, NMR, TGA, DSC, chemical structures, properties and images—in a centralized and homogeneous way. A pilot study at a pharmaceutical company demonstrated possible time savings between 20% and 80% at various points in the preformulation workflow.
|Exploring Reverse Transcription for DNA MicroArrays|
Miroslava Cuperlovic-Culf, Adrian S. Culf, Dominique Richard, Mark LaFlamme, Daniel Leger and Rodney J. Ouellette
Results suggest that random priming is the optimal method for expression analysis of long genes. This method of RT may be appropriate for alternatively spliced genes and for genes without unique probes in the 3’-region.
|Protein Expression Profiling with High-Content Antibody Arrays using Universal Linkage System ULS™ Protein Labeling|
Frank Opdam, Saskia Schoenmakers, Marie Lacombe, Sandra van der Locht, Alain van Gool and Paul van der Hoeven
The Universal Linkage System (ULS™) is a platinum-based technology that allows direct labeling of proteins and nucleic acids with a large variety of labels and haptens, including many fluorophores, biotin, and dinitrophenol.
|Carbon Nanotubes by Microwave Plasma Enhanced Chemical Vapor Deposition|
M. Maschmann, A. Goyal, Z. Iqbal, T.S. Fisher, R. Gat
MICROWAVE Plasma generates radical density characteristic of 2000C at much lower effective temperature and can be highly ionized (Low pressure ECR mode) or highly neutral (high pressure mode).
|Metabonomics for MolPAGE Discovering Diabetes Biomarkers|
K. Magnus Åberg, Mark Jairaj, Henrik Toft Pedersen, Dorrit Baunsgaard
MolPAGE (Molecular Phenotyping to Accelerate Genomic Epidemiology) is an EU consortium with almost twenty collaborating universities and companies throughout Europe. One of the aims of MolPAGE is to find early onset biomarkersfor type 2 diabetes (T2DM) and cardio-vascular diseases(CVD).
|Microwave-Accelerated Fischer Glycosidation|
Laurent F. Bornaghi and Sally-Ann Poulsen
Fischer glycosidation appeared an ideal candidate for the application of microwave irradiation and herein we report a systematic analysis of the effect of microwave heating in the Fischer glycosidation reaction.
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