Application of Modeling to Scale-Up Dissolution in Pharmaceutical ManufacturingThis article attempts to provide a model-based approach to scale-up dissolution process from a 2 l lab-scale vessel to a 4,000 l scale vessel used in manufacturing.
Continuous Preparation of Carbon-Nanotube-Supported Platinum Catalysts in a Flow Reactor Directly Heated by Electric CurrentResearchers from Clausthal University of Technology present a continuous process for the production of highly active Pt catalysts supported by carbon nanotubes by use of an electrically heated tubular reactor.
Multistep Flow Synthesis of Vinyl Azides and their use in the Copper-Catalyzed Huisgen-type Cycloaddition under Inductive-Heating ConditionsIn this article, researchers from Leibniz University Hannover report the multistep flow synthesis of vinyl azides and their application in the synthesis of vinyltriazoles.
Efficient and Selective Chemical Transformations under Flow Conditions: The Combination of Supported Catalysts and Supercritical FluidsThis paper reviews the current trends in the combined use of supported catalytic systems, either on solid supports or in liquid phases and supercritical fluids.
The Eschenmoser Coupling Reaction under Continuous-Flow ConditionsIn this paper, researchers from Technische Universität Ilmenau investigate the reaction kinetics of the Eschenmoser coupling reaction.
Scaling up of Continuous-Flow, Microwave-Assisted, Organic Reactions by Varying the Size of Pd-Functionalized Catalytic MonolithsChanging the volumetric capacity of the monolith under optimal reaction conditions was shown to increase the quantity of product from 31 mg per hour to 340 mg per hour.
Evaluation of a Commercial Packed Bed Flow Hydrogenator for Reaction Screening, Optimization and SynthesisScientists from Amgen have evaluated the performance of the ThalesNano H-Cube(®)in the context of small scale reaction screening and optimization.
Homocoupling of Aryl Halides in Flow: Space Integration of Lithiation and FeCl3 Promoted HomocouplingIntegration of the generation of aryllithiums by halogen–lithium exchange and FeCl3 promoted homocoupling has been effectively accomplished in an integrated flow microreactor system.
Continuous Flow Photolysis of Aryl Azides: Preparation of 3H-AzepinonesThis article describes the development of a continuous flow variant for the preparation of 7-membered nitrogen-containing heterocycles and demonstrates how the reaction can be further optimized using a flow system.
Continuous Flow Hydrogenation using Polysilane-Supported Palladium/Alumina Hybrid CatalystsResearchers from The University of Tokyo have developed continuous flow systems for hydrogenation using polysilane-supported palladium/alumina (Pd/(PSi-Al(2)O(3))) hybrid catalysts.
