NIH Common Fund Researchers Uncover Structure of Important Target for Drug Design
Researchers have uncovered a potent class of small molecules that selectively turn on the S1P1 receptor.

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"Popeye" Proteins Help the Heart Adapt to Stress
Study help scientists to develop new treatments for abnormal heart rhythms.

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Rapid Bone Loss Possible Side Effect of Anti-Obesity Drug
Research from UT Southwestern Medical Center has raised concern about the safe use of fibroblast growth factor 21.

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NIH Study Uncovers Probable Mechanism Underlying Resveratrol Activity
Findings may settle scientific debate surrounding this chemical found in red wine and other foods.

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Proteomic Analysis of Zebrafish Caudal Fin Regeneration
Researchers have analyzed the biomechanism of zebrafish caudal fin regeneration at various time points based on differential proteomics approaches.

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OGT Releases New Whitepaper for Aiding Biomarker Discovery
The new document explores the need for biomarkers as indicators of disease, and discusses the vast potential of autoantibodies as markers of early disease development.

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Proteomics Analyses of the Opportunistic Pathogen Burkholderia vietnamiensis using Protein Fractionations and Mass Spectrometry
Researchers from the University of Arizona have identified more than 1200 proteins, approximately 16% of the proteins coded from the annotated genome of Burkholderia species.

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Important Gene-Regulation Proteins Pinpointed by New Method
A novel technique has been developed and demonstrated at Penn State to map the proteins that read and regulate chromosomes.

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Miraculins Files with Health Canada for PreVu Medical Device License
The medical diagnostic company announced that it has filed a class II medical device license application with Health Canada for the PreVu Non-Invasive Skin Cholesterol Point of Care (POC) Test.

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NIH Study Shows 32 Million Americans Have AutoAntibodies that Target their Own Tissues
Researchers in Gainesville at the University of Florida also participated in the study.

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OGT Signs Licensing Deal for Colorectal Cancer Biomarkers
OGT has entered into an exclusive licensing agreement with Inven2.

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EPI Collaborates with the University of Texas MD Anderson Cancer Center
EPI collaborates on Liquid Tissue® personalized medicine assays in lung cancer treatment.

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Quincy Bioscience Begins Recruitment for Migraine Study
Study will evaluate the effectiveness of the jellyfish calcium-binding protein apoaequorin on quality of life for migraine sufferers.

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Stephen Zaniboni Joins Trovagene, Inc. as Chief Financial Officer
Mr. Zaniboni's experience includes raising more than $500 million through venture financing and IPO proceeds.

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SemBioSys and Tasly Pharmaceutical to Participate in the 5th CCBF and Signing Ceremony
New joint venture focused on multi-million dollar short-term revenue opportunities.

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Applied Proteomics Appoints CEO Following Series B Financing
Applied Proteomics Inc. announce the appointment of Peter Klemm, Ph.D., as chief executive officer after securing $22.5 million Series B financing.

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SemBioSys and Tasly Joint Venture Receives Chinese Government Approvals and Business License
New joint venture focused on multi-million dollar short-term revenue opportunities.

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Miraculins' PreVu Test Cleared for Sale
The company announced that its PreVu® Non-Invasive Skin Cholesterol Point of Care (POC) Test has been cleared for sale by Health Canada.

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Thomson Mass Spectrometry Laboratory Selected as Waters Center of Innovation
Waters recognizes Prof. Marcos Eberlin for pioneering mass spectrometry.

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Horizon and UK NEQAS ICC Announce Partnership to Improve Accuracy of Lung Cancer Diagnostic Testing
Horizon’s genetically defined human genomic reference standards to be used in FISH and IHC proficiency testing to help guide personalised medicine.

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Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences

Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.

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SpectraMax® Microplate Readers: A complete solution for Transcreener® assays
Molecular Devices

Transcreener® ADP2 Assays are homogenous assays with fluorescent readouts that enable the detection and screening of established drug targets including protein and lipid kinases, as well as emerging targets such as carbohydrate kinases, triphosphatases, heat shock proteins and other ATPases.

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Identification of novel autoantigensin patients with liver autoimmune diseases by Protein MicroArray
1Fondazione INGM, Istituto Nazionale Genetica Molecolare, Milan; 2Fondazione IRCCS Ospedale Maggiore Policlinico, Milano; 3Policlinico Sant’Orsola, Bologna; 4Azienda Ospedaliera Universitaria Pisana,

The characterization of autoimmune disease-specific biomarkers are of primary importance for the development of diagnostic tools and the comprehension of pathogenetic mechanisms leading to autoimmunity. To this aim a protein microarray was employed to analyze serum samples from patients with autoimmune hepatitis (e.g. AIH & PBC) and of healthy as controls. A panel of autoantigens able to discriminate among the groups of patients was identified for potential use as biomarkers.

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Fragment-Based Chemogenomics
IOTA Pharmaceuticals Ltd

A proprietary and structurally diverse fragment library has been created and screened for a variety of Gprotein coupled receptors (GPCRs) and a number of other drug targets. The data allows for a fragment-based chemogenomics study to interrogate the interactions of GPCRs and their ligands.

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Prognostic Factors for Refeeding Syndrome in Head and Neck Cancer Patients
Aintree University Hospitals NHS Foundation Trust

Head and neck cancer sufferers are inherently at risk of refeeding syndrome, which had a prevalence of 9.5% in our series. Our results suggest that site of tumour (but not tumour or nodal staging) is a prognostic indicator for developing refeeding syndrome.

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Stephanie Bougel wins Poster Award at the European Biomarkers Summit 2010
Institute of Pathology, University of Lausanne

Stephanie Bougel, from the University of Lausanne, France, won the award for best poster at the European Biomarkers Summit and Exhibtion held in Florence, Italy on the 9th - 10th November 2010.

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hTERT methylation: a potential cancer biomarker for metastasis detection in body fluids


Aim of the study: 1. To develop a specific, sensitive, quantitative, and fast method for detection of hTERT methylation 2. To explore its use as a cancer biomarker in the diagnosis of metastatic tumors in CSF.

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Hepatitis B virus (HBV) and Human immunodeficiency virus (HIV) antibodies detected by peptide microarrays
1) Institute of Virology, Universitätsmedizin Göttingen, Georg August University Göttingen, Kreuzbergring 57, D-37075 Göttingen, Germany, 2) Department of Chemical Biology, Helmholtz Centre for Infect

HBV and HIVenv chips with overlapping oligopeptides encompassing the full amino acid sequences of HBV and HIV polypeptides were produced. In addition, a chip displaying a library of random 4608 different 15-mers peptides (4608-RPL) was prepared. Both chips were used for analyzing monoclonal antibodies and sera from HIV- and HBV-infected individuals. 4608-RPL could be used for identifying target sequences of antibodies without prior knowledge of the corresponding immunizing antigen.

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An improved data processing pipe-line for comprehensive H-NMR and X/MS -omics data
Dept. Analytical Chemistry

In the post acqusition analysis of comprehensive -omics data the pre-processing pipe-line is crucial to extract the maximum possible amount of information from the data. Here we show a processing pipe-line for (1D)H-NMR and (2D)X/MS data comprising; feature detection, inter-sample feature alignment and internal-standard free normalization that outperforms today’s state-of-the-art processing schemes.

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Alignment of 1H-NMR data using a Generalized Fuzzy Hough Transform
Stockholm University,Astra Zeneca

In metabolic profiling, multivariate data analysis techniques are used to interpret 1D 1H–NMR data. Multivariate data analysis techniques require that peaks are located in the same variables in every spectrum – this requirement is not met in native NMR spectra. Current state-of-the-art alignment algorithms are unable to align peaks when the spatial order of the peaks changes. We present the Fuzzy Generalized Hough Transform alignment which solves the alignment problem.

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Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.

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Optimizing the Labeling of Proteins
Molecular Devices

The Threshold® Immuno-Ligand Assay (ILA) adapts reagents used in ELISA, RIA or radioreceptor assays for the Threshold System by covalently attaching biotin or fluorescein labels to the binding proteins and/or ligands. To simplify labeling and purification of proteins, Molecular Devices has formulated biotin and fluorescein as N-hydroxysuccinimide esters.

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Comparison of Performance: EnSpire Multimode Plate Reader and Corning® Epic® System
PerkinElmer

In recent years, label-free technology has gained momentum as an innovative tool in the fields of cellular research and biochemical binding assays. This application note demonstrates the comparable performance of the EnSpire Multimode Plate Reader to the Corning® Epic® System.

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Dispense Liquids Containing Proteins More Reliably with Reverse Pipetting
Thermo Fisher Scientific

This application note demonstrates how the reverse pipetting technique can improve the repeatability of dispensing liquids that contain proteins.

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Rapid and Reproducible DNA Isolation from 1 ml of Whole Blood with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific

This application note shows the benefits of KingFisher Flex by using genomic DNA isolation from blood as an example.

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Device Qualification of the Thermo Scientific Finnpipette Novus Electronic Pipette (IQ/OQ/PQ)
Thermo Fisher Scientific

During device qualification, one verifies and documents whether the equipment, in this case a pipette, is reliable and capable of fulfilling the requirements of its intended use. All qualification activities are fully documented according to pertinent quality and regulatory requirements and signed by authorized personnel.

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Use of Thermo Scientific Finnpipette Novus Electronic Pipettes for Accurate and Efficient Preparation of Standard Curves
Thermo Fisher Scientific

This application note discusses the use of a Thermo Scientific Finnpipette Novus Electronic Pipette for the preparation of standard curves. With 10 different functions, the versatile Novus Electronic pipette can perform most every standard curve required. The pipette’s performance was compared to a manual Thermo Scientific Finnpipette model to determine if there were appreciable differences in pipetting speed and accuracy during curve preparation.

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Validated Luminometric DLR™ Reporter Gene Assay with Thermo Scientific Varioskan® Flash
Thermo Fisher Scientific

One of the most common luminometric assays is Dual Luciferase® Reporter Assay from Promega corp. This application note shows how this assay is performed with Varioskan Flash multitechnology microplate reader. The note includes the performance of the normal DLR assay and results from some tests showing important aspects of the basic behaviour and performance of the DLR™ chemistry. This paper describes the overall efficiency of the Varioskan Flash in the measurement of DLR assay.

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microRNA Microarray Service
LC Sciences

Characterization of breast cancer using microRNA expression profiling and epigenomic and proteomic measurements in rat model.

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BD Cytometric Bead Array Cell Signaling Flex Set System
BD Biosciences

The BD™ Cytometric Bead Array (CBA) Cell Signaling Flex Set system lets you achieve high productivity in cell signaling studies by extracting more data from less sample faster than traditional Western blot techniques.

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