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From Sequencing to Interpretation: Bioin...Learn to pipette like a pro...Quantitative Top-Down Proteomics & Its I...

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Webcast - The Lipidyzer™ Platform: A Revolutionary Tool for Understanding the Role of Lipids in DiseaseThe Lipidyzer™ Platform: A Revolutionary Tool for Understanding the Role of Lipids in Disease
Join us to learn about the key challenges in lipid analysis and how the Lipidyzer platform can help you overcome them.
Webcast - Walk-Away Monitoring of Cytotoxicity, Viability and ApoptosisWalk-Away Monitoring of Cytotoxicity, Viability and Apoptosis
Join us to learn how to simplify and automate cell viability and cytotoxicity assessment for your cell analysis workflows.

Market Reports
Multi-Channel Pipettor QC Trends 2014

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Companion Diagnostics and Personalized Medicine
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the companion diagnostics (CDx) and personalized medicine marketplace. Personalized medicine is a broad field with several stakeholders all of which must be aligned in order to capture the immense potential value in targeting therapeutics to the correct patient population—the field of stratified medicine.
MicroRNAs and Exosomes
Select Biosciences Ltd

In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
Single Cell Omics 2011
Select Biosciences Ltd

The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights

This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights

Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Advances in the Use of Biomarkers in Biochip and Microarray Testing: Innovative Technologies, Growth Opportunities and the Future Market Outlook
Business Insights

The microarray market (estimated at $788m for 2008, including about $130m in protein arrays) is forecast to grow by 9% per annum to $1322m in 2013. Diagnostic microarrays, currently with just $39m (5% of the total), are expected to reach $187m (14%) by 2013. The leading diagnostic application at present is cancer.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd

This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
Scientific News
Featured Article
Integrated Omics Analysis
Studying multi-omics promises to give a more holistic picture of the organism and its place in its ecosystem, however despite the complexities involved those within the field are optimistic.

RNA-Binding Proteins Role in ALS Revealed
Researchers describe how damage to RNA-binding protein contributes to ALS, isolating a possible therapeutic target.
NIH Study Determines Key Differences between Allergic and Non-Allergic Dust Mite Proteins
Researchers at NIH have uncovered factors that lead to the development of dust mite allergy and assist in the design of better allergy therapies.
Study Finds Key Regulator in Pulmonary Fibrosis
Researchers identify an enzyme that could open the way to therpies for chronic fatal lung disease.
Alzheimer’s-Linked Protein May Play Role in Schizophrenia
Researchers suggests a protein linked to cognitive decline in Alzheimer's also plays a role in genetic predisposition to schizophrenia.
Peptides vs. Superbugs
Scientists successfully develop a shuttle system made of liquid-crystalline nanomaterials that protect peptites.
Immune Approach Targets Humans Instead of Bacteria
Scientists show for the first time how bacterial superantigen toxins work, and how short peptides can block them and save lives.
Cocoa Compound Linked to Some Cardiovascular Biomarker Improvements
The study highlights the urgent need for large, long-term RCTs that improve understanding of how the short-term benefits of cocoa flavanol intake on cardiometabolic biomarkers may be translated into clinical outcomes.
Could 2D Mass Spec Breakthrough Lead to Medical Revolution?
Pharmaceutical research could be quicker and more precise, thanks to an innovative breakthrough in 2D mass spec from the University of Warwick.
Less is More in Ribosome Assembly
Research uncovers genetic "program" that allows for ribosome formation with a limited supply of magnesium.
Business News
Call for Entries: Eppendorf Award 2017!
From October 1, 2016, until January 15, 2017, young researchers not older than 35 years, with an advanced degree, who are working in Europe can apply for the Eppendorf Award for Young European Investigators.
Active Motif, Swift Biosciences Partner
Partnership aims to develop technical advancements for epigenetics research.
Quanterix, ImmunArray Collaborate
Collaboration aims to continue advancing research and technology in order to provide an accurate method for detecting mild to moderate traumatic brain injury in the future.
Bruker, 3M Expand License Agreement
Bruker has expanded its license agreement with 3M for the processing of formalin fixed parafin embedded (FFPE) tissue sections.
Forging Collaborations to Progress Against Cancer
NCI take steps to further international collaborations to expand cancer research.
100,000 Genome Project Aided by GenomOncology
GenomOncology’s Knowledge Management System will be used to analyse cancer samples in the 100,000 Genomes Project.
CGI, BARC Partner
Partnership aims to offer comprehensive clinical trial and companion diagnostic solutions for the oncology industry.
St. Jude Children’s Research Hospital, Sanger Institute Collaborate
Collaboration aims to full exchange of cancer mutation data to support the discovery and understanding of genetic mutations causing cancers.
SELLAS Announces Entry into Cooperative R&D Agreement
The cooperative agreement with NHLBI and NIH aims to develop effective testing for MRD and diagnostics for AML.
Caprion Acquires the Immune Monitoring Laboratory from ImmuneHealth
Caprion Biosciences has announced that the company has acquired the assets of the immune monitoring laboratory of ImmuneHealth, ASBL.

7th International Conference a
24 Oct 2016
7th International Conference a ...
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Cancer Immunotherapy & Bioflui
01 Nov 2016
Cancer Immunotherapy & Bioflui ...
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Mass Spectrometry and Proteomi
14 Nov 2016
Mass Spectrometry and Proteomi ...
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EMBO Conference: From Function
12 Nov 2016
EMBO Conference: From Function ...
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The Chemical Synthesis of Long and Highly Modified RNA using 2'-ACE Chemistry
GE Healthcare Dharmacon, Inc.

Dharmacon has previously developed a novel RNA synthesis chemistry making RNA synthesis as reliable, accessible and of comparable quality as routinely observed in DNA synthesis.
Blood Transcriptomic Diagnosis of Active TB with Five Genes
1Infection & Immunity, University College London, UK 2Department of Microbiology, University College London Hospitals NHS Trust, UK 3Blizard Institute, Queen Mary Univ

This study aimed to identify the minimal set of genes that can accurately diagnose active TB, both pulmonary and extrapulmonary, and evaluate their specificity.
Experimental design considerations for efficient and specific gene knockin using a CRISPR-Cas9 for HDR with synthetic crRNA and tracrRNA
Dharmacon, part of GE Healthcare

Precise genome engineering with CRISPR-Cas9 and single-stranded DNA oligo or double-stranded DNA plasmid donors via homology-directed repair (HDR).
Exosomes promote survival in squamous head and neck cancer cells after ionizing radiation
Helmholtz Zentrum München, Institute of Radiation Biology, Neuherberg, Germany / Department of Chemistry, Technical University of Munich, Munich, Germany

Exosomes are important intercellular communicators in the acute radiation stress-response. These nanometer-sized extracellular vesicles confer protective signals to neighboring cells and therefore promote the tumorigenic and radioresistant phenotype of head and neck cancer cells.
Super-resolution single molecule localization microscopy of the exocytotic machinery underlying insulin secretion.
Heriot-Watt Univeristy

Single molecule imaging of the tSNARE proteins involved in insulin secretion.
A Synthetic CRISPR-Cas9 System for Homology-directed Repair
Dharmacon (part of GE Healthcare)

Synthetic, dual-RNA-encoded Cas9 is used for precise homology-directed repair (HDR) gene engineering. Both short and long (GFP) inserts are covered.
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
Dharmacon (part of GE Healthcare)

CRISPR-Cas9 gene editing using synthetic crRNA:tracrRNA or sgRNA is highly efficient and easy to use. Synthetic crRNA:tracrRNA is uniquely suited to in vitro and in vivo applications, in particular, DNA-free approach with Cas9 mRNA. Chemical synthesis of guide RNAs allows accurate and rapid production of arrayed crRNA libraries for high-confidence, loss-of-function screens.
Deep Phenotyping - Harnessing Data Richness for Unsupervised High-Content Analysis
Institute of high performance Computing, Astar

Recognising the key challenges, we develop an end-to-end computational framework for HCA dubbed “Deep Phenotyping” that perform unsupervised analysis to leverage on the data richness for the discovery of unknown sub-phenotypes with minimal labeling cost.
Assessment of the Anti-angiogenic Effect of VEGFR2 siRNA in Clonetics™ HUVEC using the Lonza 4D-Nucleofector™ System
1Lonza India Pvt Ltd, Hyderabad, India; 2Lonza Cologne GmbH, Cologne, Germany; 3Lonza Walkersville, Inc., Walkersville, MD, U.S.A.

In the current study we have used siRNA targeting VEGFR2 as an example to study knockdown of VEGFR2 and subsequent inhibition of tube formation by HUVECs on Growth Factor Reduced Matrigel™ in a 96-well plate format. The same strategy can be used for screening and validating siRNA based inhibitors of the angiogenic process in vitro and thus could be of utility in anti-cancer screening strategies.
The Case for CASE: Computer-Assisted Structure Elucidation

Modern CASE systems such as Structure Elucidator Suite provide the necessary capability to accurately elucidate a novel chemical structure for complex molecules based on readily available NMR data sets. This allows organizations to avoid expensive, labor-intensive, and time-consuming synthetic efforts.
Application Notes
A Novel Lipid Screening Platform that Provides a Complete Solution for Lipidomics Research

The Lipidyzer™ Platform, powered by Metabolon®.
Novel Chemical Standards Kits Enable Facile Lipid Quantitation

The Lipidyzer platform provides more accurate lipid analysis with less quantitative bias.
Evaluation of a New Accurate, Automated and Cost-effective Approach for the Analysis of Pharmacologically Important Copy Number Variation
Douglas Scientific

The IntelliQube® from Douglas Scientific® is designed to address the need for accurate and reliable results for studies such as CNV determination.
Polyol-Induced Increases in Thermal Stability of Antibodies by DSC
Malvern Instruments Limited

The goal of the study was to understand how the size of a polyol and orientation of the hydroxyl group influence the amount of thermal stability that could be induced upon seven monoclonal antibodies of different isotypes.
Engineering Monoclonal Antibodies to Enhance Drugability: A Case Study
Malvern Instruments Limited

In this manuscript we compare the stability of three different engineered antibodies as determined by SEC-HPLC analysis during accelerated stability studies, with the stability predicted by DSC.
Automated Sample Preparation - Analysis of 25-OH-Vitamin D3 and 25-OH-Vitamin D2 by LC/MS/MS
Beckman Coulter Life Sciences

Automated Sample Preparation for the Monitoring of Pharmaceutical and Illicit Drugs by LC-MS/MS
Beckman Coulter Life Sciences

Automated Sample Preparation for the Monitoring of Ethanol Metabolites in Urine by LC-MS/MS
Beckman Coulter Life Sciences

Automating Protein Digestion for Reproducible Proteomics
Beckman Coulter Life Sciences

Microcalorimetry As A Tool For Structural Biology
Malvern Instruments Limited

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