Wednesday, May 30, 2012
Technology Networks
Technology Networks
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 | Chemical Restriction Length Polymorphism (CLFP) for Detection and Characterization of Bacterial Pathogens Byron Brehm-Stecher, Iowa State University, speaking at Advances in Biosensors and Biotedection 2011. |
 | Homology-Driven Proteomics by LC-MS/MS Dr. Andrej Shevchenko, Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), speaking at Mass Spec Europe 2011. |
Competitor Analysis: Anti-Obesity Peptides and Biologics
La Merie
The report provides a competitor evaluation in the field of R&D projects with anti-obesity peptides and biologics as of February 2012. Purchase of the downloadable pdf report includes a 6-month online access to the data of the report and any updates since the publication date. The database also contains information about discontinued projects.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Biochips - Products, Applications, Technologies and End-Use Markets Growth Analysis, 2009-2015
Axis Research Mind
The report reviews the latest biochips market trends with a perceptive attempt to disclose the near-future growth prospects. An in-depth analysis on a geographic basis provides strategic business intelligence for life science sector investments. The study reveals profitable investment strategies for pharmaceutical manufacturers, biotechnology companies, laboratories, Contract Research Organizations (CROs), government organizations and many more in preferred locations.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights
This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights
Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Advances in the Use of Biomarkers in Biochip and Microarray Testing: Innovative Technologies, Growth Opportunities and the Future Market Outlook
Business Insights
The microarray market (estimated at $788m for 2008, including about $130m in protein arrays) is forecast to grow by 9% per annum to $1322m in 2013. Diagnostic microarrays, currently with just $39m (5% of the total), are expected to reach $187m (14%) by 2013. The leading diagnostic application at present is cancer.
La Merie
The report provides a competitor evaluation in the field of R&D projects with anti-obesity peptides and biologics as of February 2012. Purchase of the downloadable pdf report includes a 6-month online access to the data of the report and any updates since the publication date. The database also contains information about discontinued projects.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Biochips - Products, Applications, Technologies and End-Use Markets Growth Analysis, 2009-2015
Axis Research Mind
The report reviews the latest biochips market trends with a perceptive attempt to disclose the near-future growth prospects. An in-depth analysis on a geographic basis provides strategic business intelligence for life science sector investments. The study reveals profitable investment strategies for pharmaceutical manufacturers, biotechnology companies, laboratories, Contract Research Organizations (CROs), government organizations and many more in preferred locations.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights
This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Biomarkers in Late-Stage Clinical Trials: Applications, opportunities and activities of leading players
Business Insights
Biomarkers reduce the attrition rate of late-stage clinical trials by assessing drug potential in terms of efficacy and toxicity at the early stages of clinical development. Thus, biomarkers significantly increase productivity, lower the cost and duration of clinical trials, and help researchers complete the drug development process at a faster pace.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Advances in the Use of Biomarkers in Biochip and Microarray Testing: Innovative Technologies, Growth Opportunities and the Future Market Outlook
Business Insights
The microarray market (estimated at $788m for 2008, including about $130m in protein arrays) is forecast to grow by 9% per annum to $1322m in 2013. Diagnostic microarrays, currently with just $39m (5% of the total), are expected to reach $187m (14%) by 2013. The leading diagnostic application at present is cancer.
More than Meets the Eye
‘Transformer’ protein makes different sized transport pods.
Molecular `On-Off’ Switch Discovered by Dundee Scientists
New molecular switch protects the brain from developing Parkinson’s disease.
Algae-Produced Surface Protein Elicits Antibodies That Inhibit Malaria Transmission
In this study, scientists tested whether algal chloroplasts can produce malaria transmission blocking vaccine candidates, Plasmodium falciparum surface protein 25 (Pfs25) and 28 (Pfs28).
Picking Apart the Cell’s Most Complex Structure
One of the most important structures in a cell is the nuclear pore complex — a tiny yet complicated channel through which information flows in and out of the cell’s nucleus, directing all other cell activity.
Strengthening Proteins with Polymers
Researchers describe how they synthesized polymers to attach to proteins in order to stabilize them during shipping, storage and other activities.
Reliable and Rapid Characterization of Functional FCN2 Gene Variants Reveals Diverse Geographical Patterns
In this study, scientists genotyped and characterized four FCN2 functional SNP variants in West Africans, South Americans, South East Asians from Vietnam and Caucasians from Germany using an available rapid, reliable and cost effective FRET-RTPCR methodology.
Using a Spike-in Experiment to Evaluate Analysis of LC-MS Data
Data from the spike-in experiment can be used for developing and optimizing LC-MS data preprocessing algorithms and to evaluate workflows implemented in existing software tools.
New Biomarkers Could Offer Vital Clues for Cancer Research
European funding for cancer research has led to some interesting results in recent years, says Carl-Johan Ivarsson, CEO at Qlucore.
Scientists Uncover Exciting Lead into Premature Ageing and Heart Disease
Scientists increase life span of mice by reducing levels of SUN1 protein.
Warwick Researchers Solve 40-year-old Fourier Transform Mass Spectrometry Phasing Problem
Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry at no extra cost.
‘Transformer’ protein makes different sized transport pods.
Molecular `On-Off’ Switch Discovered by Dundee Scientists
New molecular switch protects the brain from developing Parkinson’s disease.
Algae-Produced Surface Protein Elicits Antibodies That Inhibit Malaria Transmission
In this study, scientists tested whether algal chloroplasts can produce malaria transmission blocking vaccine candidates, Plasmodium falciparum surface protein 25 (Pfs25) and 28 (Pfs28).
Picking Apart the Cell’s Most Complex Structure
One of the most important structures in a cell is the nuclear pore complex — a tiny yet complicated channel through which information flows in and out of the cell’s nucleus, directing all other cell activity.
Strengthening Proteins with Polymers
Researchers describe how they synthesized polymers to attach to proteins in order to stabilize them during shipping, storage and other activities.
Reliable and Rapid Characterization of Functional FCN2 Gene Variants Reveals Diverse Geographical Patterns
In this study, scientists genotyped and characterized four FCN2 functional SNP variants in West Africans, South Americans, South East Asians from Vietnam and Caucasians from Germany using an available rapid, reliable and cost effective FRET-RTPCR methodology.
Using a Spike-in Experiment to Evaluate Analysis of LC-MS Data
Data from the spike-in experiment can be used for developing and optimizing LC-MS data preprocessing algorithms and to evaluate workflows implemented in existing software tools.
New Biomarkers Could Offer Vital Clues for Cancer Research
European funding for cancer research has led to some interesting results in recent years, says Carl-Johan Ivarsson, CEO at Qlucore.
Scientists Uncover Exciting Lead into Premature Ageing and Heart Disease
Scientists increase life span of mice by reducing levels of SUN1 protein.
Warwick Researchers Solve 40-year-old Fourier Transform Mass Spectrometry Phasing Problem
Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry at no extra cost.
Link Technologies Announces Partnership with American International Chemical
AIC to distribute Link’s specialist oligonucleotide modifiers in North America.
KineMed and CHDI Foundation Collaborate
KineMed’s isotopic labeling technology and analytical expertise will be applied to measure in vivo production rates of huntingtin protein as a potential biomarker of disease state.
GSK to Fully Acquire Cellzome for £61 Million
GSK to further expand its platform technology expertise with acquisition of chemical proteomics company.
RCUK SSC Ltd Extends Contract with CRB
CRB to supply custom synthesized peptides and polyclonal and monoclonal antibodies for a further 12 months.
DNASTAR Awarded Antibody Engineering SBIR Grant
NIH awarded grant to build antibody engineering software.
Agilent Announces Winner of Fourth Annual Early Career Professor Award
Dr. Anthony Mittermaier will receive $50,000 per year for two years in his name, to support his research.
Dr Alan Schafer to head Population Genetics as CEO
Schafer brings deep experience in research, “big pharma” management and building new businesses.
Ezose Sciences and Hirosaki University to Collaborate in Glycomics Research
International study will focus on urologic cancers through use of Ezose’s GlycanMap® platform.
QIAGEN and Cardinal Health Collaborate to Offer Molecular Diagnostic Products to Smaller and Mid-Sized U.S. Hospitals
Collaboration creates distribution channel to previously underserved market segment.
Vermillion Resolves Non-Contingent Claims with Bio-Rad
Vermillion to be returned more than $1 million from escrow.
AIC to distribute Link’s specialist oligonucleotide modifiers in North America.
KineMed and CHDI Foundation Collaborate
KineMed’s isotopic labeling technology and analytical expertise will be applied to measure in vivo production rates of huntingtin protein as a potential biomarker of disease state.
GSK to Fully Acquire Cellzome for £61 Million
GSK to further expand its platform technology expertise with acquisition of chemical proteomics company.
RCUK SSC Ltd Extends Contract with CRB
CRB to supply custom synthesized peptides and polyclonal and monoclonal antibodies for a further 12 months.
DNASTAR Awarded Antibody Engineering SBIR Grant
NIH awarded grant to build antibody engineering software.
Agilent Announces Winner of Fourth Annual Early Career Professor Award
Dr. Anthony Mittermaier will receive $50,000 per year for two years in his name, to support his research.
Dr Alan Schafer to head Population Genetics as CEO
Schafer brings deep experience in research, “big pharma” management and building new businesses.
Ezose Sciences and Hirosaki University to Collaborate in Glycomics Research
International study will focus on urologic cancers through use of Ezose’s GlycanMap® platform.
QIAGEN and Cardinal Health Collaborate to Offer Molecular Diagnostic Products to Smaller and Mid-Sized U.S. Hospitals
Collaboration creates distribution channel to previously underserved market segment.
Vermillion Resolves Non-Contingent Claims with Bio-Rad
Vermillion to be returned more than $1 million from escrow.
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Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol
Italian Institute of Technology
This study assesses the influence of different ligand chemotypes on the protonation state of the catalytic dyad.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences
Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
SpectraMax® Microplate Readers: A complete solution for Transcreener® assays
Molecular Devices
Transcreener® ADP2 Assays are homogenous assays with fluorescent readouts that enable the detection and screening of established drug targets including protein and lipid kinases, as well as emerging targets such as carbohydrate kinases, triphosphatases, heat shock proteins and other ATPases.
Identification of novel autoantigensin patients with liver autoimmune diseases by Protein MicroArray
1Fondazione INGM, Istituto Nazionale Genetica Molecolare, Milan; 2Fondazione IRCCS Ospedale Maggiore Policlinico, Milano; 3Policlinico Sant’Orsola, Bologna; 4Azienda Ospedaliera Universitaria Pisana,
The characterization of autoimmune disease-specific biomarkers are of primary importance for the development of diagnostic tools and the comprehension of pathogenetic mechanisms leading to autoimmunity. To this aim a protein microarray was employed to analyze serum samples from patients with autoimmune hepatitis (e.g. AIH & PBC) and of healthy as controls. A panel of autoantigens able to discriminate among the groups of patients was identified for potential use as biomarkers.
Fragment-Based Chemogenomics
IOTA Pharmaceuticals Ltd
A proprietary and structurally diverse fragment library has been created and screened for a variety of Gprotein coupled receptors (GPCRs) and a number of other drug targets. The data allows for a fragment-based chemogenomics study to interrogate the interactions of GPCRs and their ligands.
Prognostic Factors for Refeeding Syndrome in Head and Neck Cancer Patients
Aintree University Hospitals NHS Foundation Trust
Head and neck cancer sufferers are inherently at risk of refeeding syndrome, which had a prevalence of 9.5% in our series. Our results suggest that site of tumour (but not tumour or nodal staging) is a prognostic indicator for developing refeeding syndrome.
Stephanie Bougel wins Poster Award at the European Biomarkers Summit 2010
Institute of Pathology, University of Lausanne
Stephanie Bougel, from the University of Lausanne, France, won the award for best poster at the European Biomarkers Summit and Exhibtion held in Florence, Italy on the 9th - 10th November 2010.
hTERT methylation: a potential cancer biomarker for metastasis detection in body fluids
Aim of the study: 1. To develop a specific, sensitive, quantitative, and fast method for detection of hTERT methylation 2. To explore its use as a cancer biomarker in the diagnosis of metastatic tumors in CSF.
Hepatitis B virus (HBV) and Human immunodeficiency virus (HIV) antibodies detected by peptide microarrays
1) Institute of Virology, Universitätsmedizin Göttingen, Georg August University Göttingen, Kreuzbergring 57, D-37075 Göttingen, Germany, 2) Department of Chemical Biology, Helmholtz Centre for Infect
HBV and HIVenv chips with overlapping oligopeptides encompassing the full amino acid sequences of HBV and HIV polypeptides were produced. In addition, a chip displaying a library of random 4608 different 15-mers peptides (4608-RPL) was prepared. Both chips were used for analyzing monoclonal antibodies and sera from HIV- and HBV-infected individuals. 4608-RPL could be used for identifying target sequences of antibodies without prior knowledge of the corresponding immunizing antigen.
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol
Italian Institute of Technology
This study assesses the influence of different ligand chemotypes on the protonation state of the catalytic dyad.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences
Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
SpectraMax® Microplate Readers: A complete solution for Transcreener® assays
Molecular Devices
Transcreener® ADP2 Assays are homogenous assays with fluorescent readouts that enable the detection and screening of established drug targets including protein and lipid kinases, as well as emerging targets such as carbohydrate kinases, triphosphatases, heat shock proteins and other ATPases.
Identification of novel autoantigensin patients with liver autoimmune diseases by Protein MicroArray
1Fondazione INGM, Istituto Nazionale Genetica Molecolare, Milan; 2Fondazione IRCCS Ospedale Maggiore Policlinico, Milano; 3Policlinico Sant’Orsola, Bologna; 4Azienda Ospedaliera Universitaria Pisana,
The characterization of autoimmune disease-specific biomarkers are of primary importance for the development of diagnostic tools and the comprehension of pathogenetic mechanisms leading to autoimmunity. To this aim a protein microarray was employed to analyze serum samples from patients with autoimmune hepatitis (e.g. AIH & PBC) and of healthy as controls. A panel of autoantigens able to discriminate among the groups of patients was identified for potential use as biomarkers.
Fragment-Based Chemogenomics
IOTA Pharmaceuticals Ltd
A proprietary and structurally diverse fragment library has been created and screened for a variety of Gprotein coupled receptors (GPCRs) and a number of other drug targets. The data allows for a fragment-based chemogenomics study to interrogate the interactions of GPCRs and their ligands.
Prognostic Factors for Refeeding Syndrome in Head and Neck Cancer Patients
Aintree University Hospitals NHS Foundation Trust
Head and neck cancer sufferers are inherently at risk of refeeding syndrome, which had a prevalence of 9.5% in our series. Our results suggest that site of tumour (but not tumour or nodal staging) is a prognostic indicator for developing refeeding syndrome.
Stephanie Bougel wins Poster Award at the European Biomarkers Summit 2010
Institute of Pathology, University of Lausanne
Stephanie Bougel, from the University of Lausanne, France, won the award for best poster at the European Biomarkers Summit and Exhibtion held in Florence, Italy on the 9th - 10th November 2010.
hTERT methylation: a potential cancer biomarker for metastasis detection in body fluids
Aim of the study: 1. To develop a specific, sensitive, quantitative, and fast method for detection of hTERT methylation 2. To explore its use as a cancer biomarker in the diagnosis of metastatic tumors in CSF.
Hepatitis B virus (HBV) and Human immunodeficiency virus (HIV) antibodies detected by peptide microarrays
1) Institute of Virology, Universitätsmedizin Göttingen, Georg August University Göttingen, Kreuzbergring 57, D-37075 Göttingen, Germany, 2) Department of Chemical Biology, Helmholtz Centre for Infect
HBV and HIVenv chips with overlapping oligopeptides encompassing the full amino acid sequences of HBV and HIV polypeptides were produced. In addition, a chip displaying a library of random 4608 different 15-mers peptides (4608-RPL) was prepared. Both chips were used for analyzing monoclonal antibodies and sera from HIV- and HBV-infected individuals. 4608-RPL could be used for identifying target sequences of antibodies without prior knowledge of the corresponding immunizing antigen.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices
The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Optimizing the Labeling of Proteins
Molecular Devices
The Threshold® Immuno-Ligand Assay (ILA) adapts reagents used in ELISA, RIA or radioreceptor assays for the Threshold System by covalently attaching biotin or fluorescein labels to the binding proteins and/or ligands. To simplify labeling and purification of proteins, Molecular Devices has formulated biotin and fluorescein as N-hydroxysuccinimide esters.
Comparison of Performance: EnSpire Multimode Plate Reader and Corning® Epic® System
PerkinElmer
In recent years, label-free technology has gained momentum as an innovative tool in the fields of cellular research and biochemical binding assays. This application note demonstrates the comparable performance of the EnSpire Multimode Plate Reader to the Corning® Epic® System.
Dispense Liquids Containing Proteins More Reliably with Reverse Pipetting
Thermo Fisher Scientific
This application note demonstrates how the reverse pipetting technique can improve the repeatability of dispensing liquids that contain proteins.
Rapid and Reproducible DNA Isolation from 1 ml of Whole Blood with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
This application note shows the benefits of KingFisher Flex by using genomic DNA isolation from blood as an example.
Device Qualification of the Thermo Scientific Finnpipette Novus Electronic Pipette (IQ/OQ/PQ)
Thermo Fisher Scientific
During device qualification, one verifies and documents whether the equipment, in this case a pipette, is reliable and capable of fulfilling the requirements of its intended use. All qualification activities are fully documented according to pertinent quality and regulatory requirements and signed by authorized personnel.
Use of Thermo Scientific Finnpipette Novus Electronic Pipettes for Accurate and Efficient Preparation of Standard Curves
Thermo Fisher Scientific
This application note discusses the use of a Thermo Scientific Finnpipette Novus Electronic Pipette for the preparation of standard curves. With 10 different functions, the versatile Novus Electronic pipette can perform most every standard curve required. The pipette’s performance was compared to a manual Thermo Scientific Finnpipette model to determine if there were appreciable differences in pipetting speed and accuracy during curve preparation.
Validated Luminometric DLR™ Reporter Gene Assay with Thermo Scientific Varioskan® Flash
Thermo Fisher Scientific
One of the most common luminometric assays is Dual Luciferase® Reporter Assay from Promega corp. This application note shows how this assay is performed with Varioskan Flash multitechnology microplate reader. The note includes the performance of the normal DLR assay and results from some tests showing important aspects of the basic behaviour and performance of the DLR™ chemistry. This paper describes the overall efficiency of the Varioskan Flash in the measurement of DLR assay.
microRNA Microarray Service
LC Sciences
Characterization of breast cancer using microRNA expression profiling and epigenomic and proteomic measurements in rat model.
BD Cytometric Bead Array Cell Signaling Flex Set System
BD Biosciences
The BD™ Cytometric Bead Array (CBA) Cell Signaling Flex Set system lets you achieve high productivity in cell signaling studies by extracting more data from less sample faster than traditional Western blot techniques.
Molecular Devices
The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Optimizing the Labeling of Proteins
Molecular Devices
The Threshold® Immuno-Ligand Assay (ILA) adapts reagents used in ELISA, RIA or radioreceptor assays for the Threshold System by covalently attaching biotin or fluorescein labels to the binding proteins and/or ligands. To simplify labeling and purification of proteins, Molecular Devices has formulated biotin and fluorescein as N-hydroxysuccinimide esters.
Comparison of Performance: EnSpire Multimode Plate Reader and Corning® Epic® System
PerkinElmer
In recent years, label-free technology has gained momentum as an innovative tool in the fields of cellular research and biochemical binding assays. This application note demonstrates the comparable performance of the EnSpire Multimode Plate Reader to the Corning® Epic® System.
Dispense Liquids Containing Proteins More Reliably with Reverse Pipetting
Thermo Fisher Scientific
This application note demonstrates how the reverse pipetting technique can improve the repeatability of dispensing liquids that contain proteins.
Rapid and Reproducible DNA Isolation from 1 ml of Whole Blood with Thermo Scientific KingFisher Flex
Thermo Fisher Scientific
This application note shows the benefits of KingFisher Flex by using genomic DNA isolation from blood as an example.
Device Qualification of the Thermo Scientific Finnpipette Novus Electronic Pipette (IQ/OQ/PQ)
Thermo Fisher Scientific
During device qualification, one verifies and documents whether the equipment, in this case a pipette, is reliable and capable of fulfilling the requirements of its intended use. All qualification activities are fully documented according to pertinent quality and regulatory requirements and signed by authorized personnel.
Use of Thermo Scientific Finnpipette Novus Electronic Pipettes for Accurate and Efficient Preparation of Standard Curves
Thermo Fisher Scientific
This application note discusses the use of a Thermo Scientific Finnpipette Novus Electronic Pipette for the preparation of standard curves. With 10 different functions, the versatile Novus Electronic pipette can perform most every standard curve required. The pipette’s performance was compared to a manual Thermo Scientific Finnpipette model to determine if there were appreciable differences in pipetting speed and accuracy during curve preparation.
Validated Luminometric DLR™ Reporter Gene Assay with Thermo Scientific Varioskan® Flash
Thermo Fisher Scientific
One of the most common luminometric assays is Dual Luciferase® Reporter Assay from Promega corp. This application note shows how this assay is performed with Varioskan Flash multitechnology microplate reader. The note includes the performance of the normal DLR assay and results from some tests showing important aspects of the basic behaviour and performance of the DLR™ chemistry. This paper describes the overall efficiency of the Varioskan Flash in the measurement of DLR assay.
microRNA Microarray Service
LC Sciences
Characterization of breast cancer using microRNA expression profiling and epigenomic and proteomic measurements in rat model.
BD Cytometric Bead Array Cell Signaling Flex Set System
BD Biosciences
The BD™ Cytometric Bead Array (CBA) Cell Signaling Flex Set system lets you achieve high productivity in cell signaling studies by extracting more data from less sample faster than traditional Western blot techniques.
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