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 | Computational Approaches For The Discovery Of Small Molecule Protein-Protein Interaction Inhibitors Dr Arnout Voet, RIKEN, speaking at Doscpvery Chemistry Congress 2013. |
 | Microelectronics Meets Microfluidics: Hybrid Integration of Sensors in Microfluidic Devices Holger Becker, Microfluidic ChipShop GmbH, speaking at Lab-on-a-Chip World Congress 2012 |
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Companion Diagnostics and Personalized Medicine
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the companion diagnostics (CDx) and personalized medicine marketplace. Personalized medicine is a broad field with several stakeholders all of which must be aligned in order to capture the immense potential value in targeting therapeutics to the correct patient population—the field of stratified medicine.
MicroRNAs and Exosomes
Select Biosciences Ltd
In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
Competitor Analysis: Anti-Obesity Peptides and Biologics
La Merie
The report provides a competitor evaluation in the field of R&D projects with anti-obesity peptides and biologics as of February 2012. Purchase of the downloadable pdf report includes a 6-month online access to the data of the report and any updates since the publication date. The database also contains information about discontinued projects.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Biochips - Products, Applications, Technologies and End-Use Markets Growth Analysis, 2009-2015
Axis Research Mind
The report reviews the latest biochips market trends with a perceptive attempt to disclose the near-future growth prospects. An in-depth analysis on a geographic basis provides strategic business intelligence for life science sector investments. The study reveals profitable investment strategies for pharmaceutical manufacturers, biotechnology companies, laboratories, Contract Research Organizations (CROs), government organizations and many more in preferred locations.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights
This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Companion Diagnostics and Personalized Medicine
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the companion diagnostics (CDx) and personalized medicine marketplace. Personalized medicine is a broad field with several stakeholders all of which must be aligned in order to capture the immense potential value in targeting therapeutics to the correct patient population—the field of stratified medicine.
MicroRNAs and Exosomes
Select Biosciences Ltd
In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
Competitor Analysis: Anti-Obesity Peptides and Biologics
La Merie
The report provides a competitor evaluation in the field of R&D projects with anti-obesity peptides and biologics as of February 2012. Purchase of the downloadable pdf report includes a 6-month online access to the data of the report and any updates since the publication date. The database also contains information about discontinued projects.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Personalized Medicine Market - Advances in Human Genomics and Proteomics to Challenge Traditional Therapeutics
GBI Research
The report provides key data, information and analysis of the major trends and issues in Personalized Medicine Market. The report provides a comprehensive insight into the role of Human Genomics and Proteomics to challenge traditional therapeutics.
Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)
MarketsandMarkets
This Biomarkers Market research report categorizes on the basis of discovery technologies and application market across major indications; forecasting revenues and analyzing trends.
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Biochips - Products, Applications, Technologies and End-Use Markets Growth Analysis, 2009-2015
Axis Research Mind
The report reviews the latest biochips market trends with a perceptive attempt to disclose the near-future growth prospects. An in-depth analysis on a geographic basis provides strategic business intelligence for life science sector investments. The study reveals profitable investment strategies for pharmaceutical manufacturers, biotechnology companies, laboratories, Contract Research Organizations (CROs), government organizations and many more in preferred locations.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights
This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Scientists Identify Molecular Trigger for Alzheimer’s Disease
New research establishes nature of malfunction in protein molecules that can lead to onset of dementia.
Preclinical Tests Shows Agent Stops “Slippery” Proteins from Binding, Causing Ewing Sarcoma
Some tumors regressed to the point that cancer cells could not be detected microscopically.
Study IDs Key Protein for Cell Death
Findings may offer a new way to kill cancer cells by forcing them into an alternative programmed-death pathway.
Whole Gel Processing Procedure for GeLC-MS/MS Based Proteomics
The procedure will enable clinical proteomics for which GeLC-MS/MS is a popular workflow and sample numbers are relatively high.
Spontaneous Mutations Play a Key Role in Congenital Heart Disease
New research shows that about 10 percent of these defects are caused by genetic mutations that are absent in the parents of affected children.
Waters Users’ Meeting at ASMS 2013
Register for the Waters Users’ meeting at ASMS 2013 and learn about the latest developments in Mass Spectrometry from Waters experts as we reveal our new technologies and solutions.
Thermo Scientific at ASMS 2013
Learn how scientists and researchers are transforming science by applying innovative solutions to a wide range of qualitative and quantitative applications.
Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture
Rapid development of MS-based proteomic techniques in the last decade that has immensely helped researchers in candidate biomarker discovery.
Agilent Technologies Announces Winner of Fifth Annual Early Career Professor Award
Assistant Professor at Northwestern Recognized for Cancer Diagnostics Research.
Gene Discoveries Give Hope Against 'Brittle Bone' Disease
Scientists pinpoint mutation that appears to cause severe forms of bone loss.
New research establishes nature of malfunction in protein molecules that can lead to onset of dementia.
Preclinical Tests Shows Agent Stops “Slippery” Proteins from Binding, Causing Ewing Sarcoma
Some tumors regressed to the point that cancer cells could not be detected microscopically.
Study IDs Key Protein for Cell Death
Findings may offer a new way to kill cancer cells by forcing them into an alternative programmed-death pathway.
Whole Gel Processing Procedure for GeLC-MS/MS Based Proteomics
The procedure will enable clinical proteomics for which GeLC-MS/MS is a popular workflow and sample numbers are relatively high.
Spontaneous Mutations Play a Key Role in Congenital Heart Disease
New research shows that about 10 percent of these defects are caused by genetic mutations that are absent in the parents of affected children.
Waters Users’ Meeting at ASMS 2013
Register for the Waters Users’ meeting at ASMS 2013 and learn about the latest developments in Mass Spectrometry from Waters experts as we reveal our new technologies and solutions.
Thermo Scientific at ASMS 2013
Learn how scientists and researchers are transforming science by applying innovative solutions to a wide range of qualitative and quantitative applications.
Mass Spectrometry-Based Proteomics in Molecular Diagnostics: Discovery of Cancer Biomarkers Using Tissue Culture
Rapid development of MS-based proteomic techniques in the last decade that has immensely helped researchers in candidate biomarker discovery.
Agilent Technologies Announces Winner of Fifth Annual Early Career Professor Award
Assistant Professor at Northwestern Recognized for Cancer Diagnostics Research.
Gene Discoveries Give Hope Against 'Brittle Bone' Disease
Scientists pinpoint mutation that appears to cause severe forms of bone loss.
EMBO Announces 52 New Members for 2013
EMBO announced today that 52 outstanding researchers in the life sciences were newly elected to its membership.
Ignyta Announces Acquisition of Actagene Oncology and Entry into Oncology Personalized Medicine
Company adds world class drug discovery and development veterans to management and advisory team.
Olink Bioscience Appoints Sigma-Aldrich as Distributor of Duolink
Olink Bioscience will continue to develop the protein biomarker market.
Bruker and SCiLS GmbH Announce an Exclusive Partnership
SCiLS Lab is the software developed by SCiLS GmbH which allows the user-friendly statistical analysis of large MALDI imaging datasets.
Biotage and Peptide Synthesis
CEM claim to won a “patent dispute” with Biotage.
CEM Wins Peptide Patent Dispute with Biotage
The patent broadly covers the overall process of microwave peptide synthesis including the steps of deprotection and coupling.
OGT Supports Earlier Lupus Diagnosis
Superior sensitivity and specificity compared to current laboratory tests.
Aileron Therapeutics Successfully Completes First-Ever Stapled Peptide Clinical Trial
Safety and pharmacokinetics of ALRN-5281, a long-acting growth-hormone-releasing-hormone agonist, established in single-ascending dose study.
Selventa Strengthens Intellectual Property for SysDx™ Approach to Personalized Medicine
Patent is core to Selventa’s SysDx™ approach to mining and comparing biological data for predicting a patient’s response or non-response to a drug.
Proteros and Eisai Announces Successful Completion of Collaboration
Proteros and Eisai achieve target in lead discovery project, delivering kinetically optimized lead compounds.
EMBO announced today that 52 outstanding researchers in the life sciences were newly elected to its membership.
Ignyta Announces Acquisition of Actagene Oncology and Entry into Oncology Personalized Medicine
Company adds world class drug discovery and development veterans to management and advisory team.
Olink Bioscience Appoints Sigma-Aldrich as Distributor of Duolink
Olink Bioscience will continue to develop the protein biomarker market.
Bruker and SCiLS GmbH Announce an Exclusive Partnership
SCiLS Lab is the software developed by SCiLS GmbH which allows the user-friendly statistical analysis of large MALDI imaging datasets.
Biotage and Peptide Synthesis
CEM claim to won a “patent dispute” with Biotage.
CEM Wins Peptide Patent Dispute with Biotage
The patent broadly covers the overall process of microwave peptide synthesis including the steps of deprotection and coupling.
OGT Supports Earlier Lupus Diagnosis
Superior sensitivity and specificity compared to current laboratory tests.
Aileron Therapeutics Successfully Completes First-Ever Stapled Peptide Clinical Trial
Safety and pharmacokinetics of ALRN-5281, a long-acting growth-hormone-releasing-hormone agonist, established in single-ascending dose study.
Selventa Strengthens Intellectual Property for SysDx™ Approach to Personalized Medicine
Patent is core to Selventa’s SysDx™ approach to mining and comparing biological data for predicting a patient’s response or non-response to a drug.
Proteros and Eisai Announces Successful Completion of Collaboration
Proteros and Eisai achieve target in lead discovery project, delivering kinetically optimized lead compounds.
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Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor
Dr. Hari Singh Gour University, Sagar
The objective of the present project is to develop transferrin coupled biodegradable nanoparticles (NPs) with high encapsulation efficiency (Doxorubicin). GALA (Glutamic acid-alanine-leucine alanine) a pH sensitive fusogenic endosomolytic peptide is added to the formulation to enhance the endosomal lysis that will further potentiate the delivery of anticancer drug inside tumor cell as well as prevent loss of drug via endosomes.
Fast Liquid Differential Scanning Calorimetry (FLDSC)
Xensor Integration
Lysozyme experiments show that protein unfolding can be recorded at scan rates of up to 1000 °C/s, and for lysozyme concentrations of 1 % and probably even down to 0.1%.
Protein Microarrays for Characterisation of the Bacillus anthracis ‘infectome’
Health Protection Agency
These studies provide an interesting insight into the transcriptome of virulent B. anthracis in a host infection environment.
Monitoring Protein Synthesis in Living Cells With Fluorescent Labeled tRNA FRET Pairs
Anima Cell Metrology, Inc
We transfect cells with tRNAs labeled as FRET donors and acceptors. A FRET signal is generated only when a donor labeled tRNA and an acceptor-labeled tRNA come in close contact (< 7 nM), as they do on the ribosome during the elongation cycle. The intensity of the FRET signal correlates with the number of ribosomes engaged in protein synthesis, providing a real-time, live-cell assay for measuring rates of protein synthesis.
Determination and Comparison of Specifics of Nucleus Pulposus Cells of Human Intervertebral Disc in Alginate and Chitosan– Gelatin Scaffolds
Tehran University of Medical Sciences
In this work we studied specefices of NP cells obtained from nucleus pulposus by collagenase enzymatic hydrolysis obtained from patients undergoing open surgery.
Improved Ligation Specificity with Chemically Modified Ligation Components
TriLink BioTechnologies, Inc.
Ligases are gaining utility in molecular biology applications, such as nucleotide sequence detection, single nucleotide polymorphism (SNP) detection, protein detection and “next generation” sequencing by ligation.
Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol
Italian Institute of Technology
This study assesses the influence of different ligand chemotypes on the protonation state of the catalytic dyad.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences
Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
SpectraMax® Microplate Readers: A complete solution for Transcreener® assays
Molecular Devices
Transcreener® ADP2 Assays are homogenous assays with fluorescent readouts that enable the detection and screening of established drug targets including protein and lipid kinases, as well as emerging targets such as carbohydrate kinases, triphosphatases, heat shock proteins and other ATPases.
Dr. Hari Singh Gour University, Sagar
The objective of the present project is to develop transferrin coupled biodegradable nanoparticles (NPs) with high encapsulation efficiency (Doxorubicin). GALA (Glutamic acid-alanine-leucine alanine) a pH sensitive fusogenic endosomolytic peptide is added to the formulation to enhance the endosomal lysis that will further potentiate the delivery of anticancer drug inside tumor cell as well as prevent loss of drug via endosomes.
Fast Liquid Differential Scanning Calorimetry (FLDSC)
Xensor Integration
Lysozyme experiments show that protein unfolding can be recorded at scan rates of up to 1000 °C/s, and for lysozyme concentrations of 1 % and probably even down to 0.1%.
Protein Microarrays for Characterisation of the Bacillus anthracis ‘infectome’
Health Protection Agency
These studies provide an interesting insight into the transcriptome of virulent B. anthracis in a host infection environment.
Monitoring Protein Synthesis in Living Cells With Fluorescent Labeled tRNA FRET Pairs
Anima Cell Metrology, Inc
We transfect cells with tRNAs labeled as FRET donors and acceptors. A FRET signal is generated only when a donor labeled tRNA and an acceptor-labeled tRNA come in close contact (< 7 nM), as they do on the ribosome during the elongation cycle. The intensity of the FRET signal correlates with the number of ribosomes engaged in protein synthesis, providing a real-time, live-cell assay for measuring rates of protein synthesis.
Determination and Comparison of Specifics of Nucleus Pulposus Cells of Human Intervertebral Disc in Alginate and Chitosan– Gelatin Scaffolds
Tehran University of Medical Sciences
In this work we studied specefices of NP cells obtained from nucleus pulposus by collagenase enzymatic hydrolysis obtained from patients undergoing open surgery.
Improved Ligation Specificity with Chemically Modified Ligation Components
TriLink BioTechnologies, Inc.
Ligases are gaining utility in molecular biology applications, such as nucleotide sequence detection, single nucleotide polymorphism (SNP) detection, protein detection and “next generation” sequencing by ligation.
Metal Polymers, A Glue to Immobilise Proteins Onto Synthetic Surfaces
Anteo Diagnostics
The main objective of this work was to develop a surface chemistry which maintains protein function and orientation per unit surface area, regardless of the surface used.
Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol
Italian Institute of Technology
This study assesses the influence of different ligand chemotypes on the protonation state of the catalytic dyad.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences
Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
SpectraMax® Microplate Readers: A complete solution for Transcreener® assays
Molecular Devices
Transcreener® ADP2 Assays are homogenous assays with fluorescent readouts that enable the detection and screening of established drug targets including protein and lipid kinases, as well as emerging targets such as carbohydrate kinases, triphosphatases, heat shock proteins and other ATPases.
BRD4 Bromodomain 1 Inhibitor Screening Using a Homogeneous Proximity Assay
BioTek Instruments
Demonstration of profiling and primary screening of an epigenetic target; a histone acetylating bromodomain. This is a TR-FRET based application highlighting the use of automated instrumentation and a high-throughput screening (HTS) multi-mode microplate reader.
Purification of Genomic DNA from Saliva Using Oragene® Discover Collection Kits and the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling Workstation
Hamilton
In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton
The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
Tryptic Mapping Automated on the CyBi®-RoboSpense and Integration of an Agilent 1100/1200 HPLC System for Peptide Analysis
CyBio
This application note describes automation of the tryptic mapping process on the CyBi®-RoboSpense liquid handling platform. The automation is completed through integrating an Agilent 1100/1200 HPLC system.
Visualisation and Comparison of SYNAPT G2-S LC/MS Data with Progenesis LC/MS
Waters Corporation
In this technology brief, we present the precise large scale, label-free analysis of high-density proteomic LC/MS data combined with a qualitative protein strategy that accurately identifies proteins and software that accurately quantifies proteins - both with high reproducibility.
Attamole Detection of Proteins in a Complex Mixture Using the SYNAPT G2-S System
Waters Corporation
Low abundance proteins are often of biological interest and as such, sensitivity and low limits of quantification are key parameters in modern proteomic experiments. The SYNAPT® G2-S System provides improved sensitivity, resulting in the routine detection of attomole levels of tryptically-digested proteins. In this technology brief, we show results from a protein mixture spiked at different concentrations into a cytosolic E.coli lysate.
Data Independent Label-Free Quantification of Low Abundance Proteins
Waters Corporation
The depth to which a complex sample can be interrogated is crucial as this defines the lowest abundance limit of proteins that may be quantified. Waters® SYNAPT® G2-S Mass Spectrometry System has substantial improvements in performance: mass resolution and accuracy, dynamic range, and sensitivity.
Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC/MS
Waters Corporation
Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
MALDI-HDMSE: A Novel ‘Data Independent’ Acquisition Method for the Enhanced Analysis of 2D-Gel Tryptic Peptide Digests
Waters Corporation
Peptide Mass Fingerprinting (PMF) is an unbiased protein identification technique that offers limited sequence information for identification purposes due to the reliance on the m/z measurement of proteolytic peptides. This application note proposes a novel method of acquiring data called High Definition MSE (HDMSE).
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation
This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
BioTek Instruments
Demonstration of profiling and primary screening of an epigenetic target; a histone acetylating bromodomain. This is a TR-FRET based application highlighting the use of automated instrumentation and a high-throughput screening (HTS) multi-mode microplate reader.
Purification of Genomic DNA from Saliva Using Oragene® Discover Collection Kits and the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling Workstation
Hamilton
In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Hamilton
The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.
Tryptic Mapping Automated on the CyBi®-RoboSpense and Integration of an Agilent 1100/1200 HPLC System for Peptide Analysis
CyBio
This application note describes automation of the tryptic mapping process on the CyBi®-RoboSpense liquid handling platform. The automation is completed through integrating an Agilent 1100/1200 HPLC system.
Visualisation and Comparison of SYNAPT G2-S LC/MS Data with Progenesis LC/MS
Waters Corporation
In this technology brief, we present the precise large scale, label-free analysis of high-density proteomic LC/MS data combined with a qualitative protein strategy that accurately identifies proteins and software that accurately quantifies proteins - both with high reproducibility.
Attamole Detection of Proteins in a Complex Mixture Using the SYNAPT G2-S System
Waters Corporation
Low abundance proteins are often of biological interest and as such, sensitivity and low limits of quantification are key parameters in modern proteomic experiments. The SYNAPT® G2-S System provides improved sensitivity, resulting in the routine detection of attomole levels of tryptically-digested proteins. In this technology brief, we show results from a protein mixture spiked at different concentrations into a cytosolic E.coli lysate.
Data Independent Label-Free Quantification of Low Abundance Proteins
Waters Corporation
The depth to which a complex sample can be interrogated is crucial as this defines the lowest abundance limit of proteins that may be quantified. Waters® SYNAPT® G2-S Mass Spectrometry System has substantial improvements in performance: mass resolution and accuracy, dynamic range, and sensitivity.
Qualitative and Quantitative Characterization of the Metabolome, Lipidome, and Proteome of Human Hepatocytes Stably Transfected with Cytochrome P450 2E1 Using Data Independent LC/MS
Waters Corporation
Drug toxicity is a major reason for the failure of candidate pharmaceuticals during their development. Therefore, it is important to realize the potential for toxicity in a timely fashion. A label-free multi-omics approach has been applied for the analysis of the transfected human hepatocyte cells by implementing LC/HDMSE, providing both qualitative and quantitative information within a single experiment.
MALDI-HDMSE: A Novel ‘Data Independent’ Acquisition Method for the Enhanced Analysis of 2D-Gel Tryptic Peptide Digests
Waters Corporation
Peptide Mass Fingerprinting (PMF) is an unbiased protein identification technique that offers limited sequence information for identification purposes due to the reliance on the m/z measurement of proteolytic peptides. This application note proposes a novel method of acquiring data called High Definition MSE (HDMSE).
TransOmics Informatics Powered by Nonlinear Dynamics
Waters Corporation
This application note introduces the workflow of TransOmics Informatics Software that has been specifically developed for the larger scale analysis of ion mobility MS data from proteomics and metabolomics data sets, comprising technical and biological replicates.
