Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Sequential Genomic Analysis Links Gene with Human Kidney Aging

Published: Tuesday, October 27, 2009
Last Updated: Tuesday, October 27, 2009
Bookmark and Share
The new approach that combines sequential transcriptional profiling and eQTL mapping, can help find other genetic associations.

A gene has been associated with human kidney aging, according to researchers from Stanford University, the National Institute on Aging, the MedStar Research Institute, and the HudsonAlpha Institute for Biotechnology.

In work published on October 16 in the open-access journal PLoS Genetics, the investigators claim that their approach, which combines sequential transcriptional profiling and eQTL mapping, can be applied to any phenotype of interest to help find other genetic associations.

Kidneys age at different rates, such that some people show little or no effects of kidney aging whereas others show rapid functional decline. Determining genetic factors associated with different rates of kidney aging contributes to the understanding of molecular mechanisms underlying the human aging process. Although family studies have shown that genes play a role in longevity, it has proven difficult to identify the specific genetic variants involved, until now.

The researchers, led by Dr. Stuart Kim, first used genome-wide transcriptional profiling to determine that 630 genes change expression with age in kidney tissue. Next, they determined that 101 of these age-regulated genes contain DNA variations among individuals that associate with gene expression level. These 101 genes were tested for association with kidney aging in a combined analysis of two populations selected to study normal aging: the Baltimore Longitudinal Study of Aging and the InCHIANTI Study.

One gene that encodes an extracellular matrix protein (MMP20) was revealed to be significantly associated with kidney aging, providing the first gene association with kidney aging.

Because data from both populations were combined in the kidney aging association analysis, the researchers stress that this finding needs to be replicated in additional populations. As more aging genes are discovered and confirmed, the particular genetic variants belonging to a person could one day be combined to better predict the aging trajectory of the kidney.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Ultra-Sensitive Test for Cancers, HIV
Test developed that is thousands of times more sensitive than current diagnostics.
Tuesday, March 15, 2016
Marker Identifies Most Basic Form of Blood Stem Cell
Nearly 30 years after the discovery of the hematopoietic stem cell, Stanford researchers have found a marker that allows them to study the version of these stem cells that continues to replicate.
Wednesday, February 17, 2016
Blocking Dengue Fever Virus
By targeting fundamental cellular machinery, the antiviral approach developed in Judith Frydman's lab at Stanford could provide a roadmap to preventing infections that affect hundreds of millions of people every year.
Thursday, December 03, 2015
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Thursday, November 26, 2015
How Cell Growth Triggers Cell Division
Researchers in Jan Skotheim's lab have discovered a previously unknown mechanism that controls how large cells grow, an insight that could one day provide insight into attacking diseases such as cancer.
Wednesday, October 07, 2015
Delivering Missing Protein Heals Damaged Hearts in Animals
Researchers have discovered that a particular protein, Fstl1, plays a key role in regenerating dead heart-muscle cells.
Tuesday, September 22, 2015
Key Mechanism in Gene Expression Discovered
RNA polymerase II makes life possible by expressing genes. Now, a team of Stanford biologists, chemists and applied physicists has observed it at work in real time.
Thursday, September 17, 2015
X-ray Laser Experiment Could Help in Designing Drugs for Brain Disorders
Scientists found that when two protein structures in the brain join up, they act as an amplifier for a slight increase in calcium concentration, triggering a gunshot-like release of neurotransmitters from one neuron to another.
Monday, August 24, 2015
HIV Susceptibility Linked to Little-Understood Immune Cell Class
High levels of diversity among immune cells called natural killer cells may strongly predispose people to infection by HIV, and may be driven by prior viral exposures, according to a new study.
Thursday, July 30, 2015
Long-sought Discovery Fills in Missing Details of Cell 'Switchboard'
A biomedical breakthrough reveals never-before-seen details of the human body’s cellular switchboard that regulates sensory and hormonal responses.
Monday, July 27, 2015
A Protein's Novel Role In Several Types Of Cancers Discovered
Stanford ChEM-H scientists are helping to develop a novel cancer therapy based on a new finding of a protein that inadvertently promotes cancer growth.
Friday, February 27, 2015
Stanford Chemists Take Step Toward Solving Mystery of How Enzymes Work
Steven Boxer and his students have found that the electrostatic field within an enzyme accounts for the lion's share of its success.
Wednesday, December 24, 2014
Protein Complex May Play Role in Preventing Many Forms of Cancer, Study Shows
Researchers at the Stanford University School of Medicine have identified a group of proteins that are mutated in about one-fifth of all human cancers.
Tuesday, May 07, 2013
Scientists Identify Two Molecules that Affect Brain Plasticity in Mice
Stanford researchers have identified a set of molecular brakes that stabilize the developing brain’s circuitry.
Tuesday, December 01, 2009
Stanford Researchers Find Protein Targets for Potential Treatment of Multiple Sclerosis
Stanford researchers have identified therapy targets that could lead to personalized treatments for MS patients at each phase of the illness.
Monday, February 18, 2008
Scientific News
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
HIV Particles Used to Trap Intact Mammalian Protein Complexes
Belgian scientists from VIB and UGent developed Virotrap, a viral particle sorting approach for purifying protein complexes under native conditions.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
Computational Model Finds New Protein-Protein Interactions
Researchers at University of Pittsburgh have discovered 500 new protein-protein interactions (PPIs) associated with genes linked to schizophrenia.
New Insights into Gene Regulation
Researchers have solved the three-dimensional structure of a gene repression complex that is known to play a role in cancer.
Controlling RNA in Living Cells
Modular, programmable proteins can be used to track or manipulate gene expression.
Soy Shows Promise as Natural Anti-Microbial Agent
Soy isoflavones and peptides may inhibit the growth of microbial pathogens that cause food-borne illnesses, according to a new study from University of Guelph researchers.
Potential Target for Revolutionary Antibiotics
An international team of including the Lomonosov Moscow State University researchers discovered which enzyme enables Escherichia coli bacterium (E. coli) to breathe.
DNA Barcodes Gone Wild
A team of researchers at University of Toronto’s Donnelly Centre and Sinai Health System’s Lunenfeld-Tanenbaum Research Institute (LTRI) has developed a new technology that can stitch together DNA barcodes inside a cell to simultaneously search amongst millions of protein pairs for protein interactions.
Biomarkers for Profiling Prostate Cancer Patients
Exiqon A/S has announced the publication of validation of prognostic microRNA biomarkers for the aggressiveness of prostate cancer in independent cohorts.
Scroll Up
Scroll Down
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!