Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Blood Clotting Finding may Lead to New Treatments

Published: Thursday, February 11, 2010
Last Updated: Thursday, February 11, 2010
Bookmark and Share
Researchers find that a key protein that causes the blood to clot is produced by blood vessels in the lungs and not just the liver.

A key protein that causes the blood to clot is produced by blood vessels in the lungs and not just the liver, according to new research published in the journal PLoS One, led by scientists at Imperial College London.

The findings may ultimately help scientists to develop better treatments for conditions where the blood's ability to clot is impaired, including deep vein thrombosis, where dangerous blood clots form inside the body, and haemophilia A, where the blood cannot clot sufficiently well.

It has long been known that an agent called factor VIII plays a key role in enabling the blood to clot. Too much factor VIII puts people at risk of excessive clots. Low levels of factor VIII cause bleeding in people with haemophilia A and factor VIII replacement is used to treat this.

Prior to recent research it had been believed that most factor VIII was produced by the liver. Therapeutic options for patients with haemophilia have included replacing liver cells, for example through transplantation.

Dr Claire Shovlin, the lead author of the study from the National Heart and Lung Institute at Imperial College London, said: "Our study suggests that the blood vessels in the lung are playing a crucial role in altering how blood clots form in the body. There are a huge number of these blood vessels - they cover an area equivalent in size to a squash court, effectively 20 times the surface area of all other blood vessels combined.

"This means it's really important for us to understand exactly how the behaviour of the lung blood vessels might be affecting diseases where blood clotting is a factor.  Further research on how the lungs modify the clotting potential of the blood flowing through them could open up new avenues for treatments," added Dr Shovlin.

In 2006, researchers from the University of Leuven in Belgium published a study in the journal Blood looking at donated lung tissue. The researchers passed fluid through the tissue and found that in three of the four lung samples studied, the levels of factor VIII increased in the fluid after passing through the lungs. They also provided evidence that some lung blood vessels could produce factor VIII in cell culture.

The researchers behind this study have confirmed that the blood vessels in the lungs should be an important site for regulating the formation of clots, both in the lungs themselves and also, potentially, in the rest of the body. They used different microscopic and biochemical techniques to look at samples of lung tissue and blood samples in minute detail.

Tissue and blood samples for the work leading up to this study were donated by patients from Imperial College Healthcare NHS Trust, with tissue processed through the Hammersmith Hospital Tissue Bank.

The team found that factor VIII could be seen in the lung tissue and was present on the surface of blood vessel cells in the lungs. They also found that factor VIII localizes in the lungs with a protein called von Willebrand factor, which protects factor VIII from degradation.

The work also showed that how the factor VIII gene may be decoded is much more complicated than previously thought. This could potentially alter how scientists approach the treatment of the many conditions where blood clotting is a factor.

The researchers hope that ultimately new drugs can be developed that target production of factor VIII in the lungs, to improve the body's ability to ensure that the blood clots properly. By targeting the lungs, the researchers think it may be possible to make more effective drugs that produce fewer side effects than current treatments.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Crucial Reaction for Vision Revealed
Scientists have tracked the reaction of a protein responding to light, paving the way for a new understanding of life's essential reactions.
Monday, May 16, 2016
Bacterial Motors Unveiled
Nanoscopic 3D imaging has revealed how different bacteria have geared their tiny propeller motors for a wide range of swimming abilities.
Thursday, March 17, 2016
Infant Milk Formula Does Not Reduce Risk of Eczema and Allergies, Says New Study
Researchers at Imperial College London have found a type of baby formula does not reduce allergy risk - despite previous claims to the contrary.
Wednesday, March 09, 2016
Flu Virus Hijacking Tactics Revealed
Scientists at Imperial College London have discovered how flu viruses 'hijack' cell machinery when they infect the body.
Thursday, January 07, 2016
Discovery of Trigger for Bugs’ Defences Could Lead to New Antibiotics
New research shows that sigma54 holds a bacterium’s defences back until it encounters stress.
Friday, August 21, 2015
Breakthrough Could Lead to New Antibiotics
Scientists have exposed a chink in the armour of disease-causing bugs, with a new discovery about a protein that controls bacterial defences.
Friday, August 21, 2015
New Genetic Form of Obesity and Diabetes Discovered
Scientists have discovered a new inherited form of obesity and type 2 diabetes in humans.
Tuesday, June 30, 2015
Protein That Boosts Immunity to Viruses and Cancer Discovered
Researchers now developing a gene therapy designed to boost the infection-fighting cells.
Saturday, April 18, 2015
Biomarker Discovery Sheds New Light on Heart Attack Risk of Arthritis Drugs
Drug may be given a new lease of life.
Thursday, December 11, 2014
First Pictures of BRCA2 Protein Show How it Works to Repair DNA
Researchers purified the protein and used electron microscopy to reveal its structure.
Thursday, October 09, 2014
Protein ‘Map’ Could Lead to Potent New Cancer Drugs
Findings will help scientists to design drugs that could target NMT enzyme.
Saturday, September 27, 2014
New Developments in Big, Open Access Data for Dementia
Prime Minister, David Cameron, pledged a UK commitment to discover new drugs and treatment that could slow down the on-set of dementia or even deliver a cure by 2025.
Thursday, June 19, 2014
New Discovery Gives Hope that Nerves Could be Repaired After Spinal Cord Injury
Research highlights the role of a protein called P300/CBP-associated factor.
Tuesday, April 08, 2014
Scientists Design Protein to Prevent Prostate Cancer Cell Growth
New protein blocks the hormone receptors and consequently stops cancer cells from growing in the laboratory.
Thursday, January 30, 2014
Designer Protein to Prevent Prostate Cancer Cell Growth
Researchers are creating a "designer" protein that could be effective at treating prostate cancer when other therapies fail.
Friday, January 17, 2014
Scientific News
Structure of Essential Digestive Enzyme Uncovered
Using a powerful combination of techniques from biophysics to mathematics, researchers have revealed new insights into the mechanism of a liver enzyme that is critical for human health.
Getting a Better Look at How HIV Infects and Takes Over its Host Cells
A new approach, developed by a team of researchers led by The Rockefeller University and The Aaron Diamond AIDS Research Center (ADARC), offers an unprecedented view of how a virus infects and appropriates a host cell, step by step.
Untangling Disease-Related Protein Misfolding
Work advances understanding of genetic forms of thrombosis, emphysema, cirrhosis of the liver, neurodegenerative diseases and inflammation, among others.
Scientists Find Evidence That Cancer Can Arise Changes
Researchers at Rockefeller University have found a mutation that affects the proteins that package DNA without changing the DNA itself can cause a rare form of cancer.
US-India Collab Finds Molecular Signatures of Severe Malaria
Study may be a significant advancement in understanding the causes of severe malaria.
Triple-Negative Breast Cancer Target Is Found
Researchers at UC Berkeley discover a target that drives cancer metabolism in triple-negative breast cancer.
Crucial Reaction for Vision Revealed
Scientists have tracked the reaction of a protein responding to light, paving the way for a new understanding of life's essential reactions.
Cancer Can Arise from Histone Mutations
A mutation that affects the proteins that package DNA—without changing the DNA itself—can cause a rare form of cancer.
Mimicking Evolution to Create Novel Proteins
A study by researchers in the Kuhlman lab offers a new route to design the 'cellular machines' needed to understand and battle diseases.
Can Gender Play A Role In Determining Cancer Treatment Choices?
MD Anderson study reveals “sex-biased” gene signatures in review of 13 cancer types.
Scroll Up
Scroll Down
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!