Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

SAW Instruments Enhances Protein Interaction Analysis with the sam®X Acoustic Biosensor

Published: Monday, June 24, 2013
Last Updated: Monday, June 24, 2013
Bookmark and Share
A robust platform for label-free biomolecular assays.

SAW Instruments is continuing to advance acoustic wave biosensor technology with the sam®X platform. Based on SAW’s Surface Acoustic Wave technology, the biosensors measure changes in mass and viscoelasticity at the chip surface based on changes in the high frequency acoustic oscillations running across the chip surface.

This innovative approach is complementary to other biophysical techniques, such as SPR and QCM for measuring protein interactions, and can also be used for samples and applications that are difficult to analyze by these other methods, thus providing additional information and insights.

The sam®X platform is ideally suited to the study of native membrane proteins and protein complexes such as the 7TM G-Protein Coupled Receptors (GPCRs), either as membrane fragments or within liposome or vesicle particles.

Such complexes can be very challenging to analyze by traditional biosensor platforms. For these therapeutically relevant targets, sam®X technology represents a new potential tool for drug discovery programs.

Closely coupled to this, many drug companies are also interested in looking at the separate conformational data from the sam®X platform (i.e. measuring the change in the acoustic wave amplitude) when using small molecule candidates against protein targets or vesicles. This can provide very valuable information on compounds whose binding induces structural changes in their targets.

In terms of practical workflow improvement and benefits, the eight channels of the dual-chip sam®X system provide more sensors for a higher throughput, and perhaps even more importantly, provide flexible fluidic channel routing which allows different samples or reagents to be delivered to discrete channels or combinations of channels on the chip.

Different proteins can also be immobilized at separate sensor position while the chip is on-line, enabling loading of the surface to full capacity, and allowing for a degree of quantification, which vastly improves data quality and assists interpretation.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

SAW Instruments Expands Presence in the US
Company has further expanded its presence in the USA by forming a new subsidiary, SAW Instruments USA, LLC, and recruiting a full time Field Application Scientist based in Boston, MA.
Monday, March 19, 2012
Scientific News
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Novel Proteins Linked to Huntington's Disease
University of Florida Health researchers have made a new discovery about Huntington's disease, showing that the gene that causes the fatal disorder makes an unexpected "cocktail" of mutant proteins that accumulate in the brain.
Enzyme Critical to Maintaining Telomere Length Discovered
New method expected to speed understanding of short telomere diseases and cancer.
New Method Identifies Up to Twice as Many Proteins and Peptides
An international team of researchers developed a method that identifies up to twice as many proteins and peptides in mass spectrometry data than conventional approaches.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
New Way to Force Stem Cells to Become Bone Cells
Potential therapies based on this discovery could help people heal bone injuries or set hardware, such as replacement knees and hips.
Long-Sought Protein Sensor for the ‘Sixth Sense’ Discovered
In a study led by scientists from The Scripps Research Institute (TSRI)the sensor protein for propioception has been identified.
How Viruses Commandeer Human Proteins
Researchers have produced the first image of an important human protein as it binds with ribonucleic acid (RNA), a discovery that could offer clues to how some viruses, including HIV, control expression of their genetic material.
Tracking How Herpes Simplex Virus Moves Through Cells
In a recent study, Derek Walsh, PhD, associate professor of Microbiology-Immunology, and his team showed how the herpes simplex virus (HSV) exploits microtubule plus-end tracking proteins to initiate transport and infection in human cells.
Essential Component of Antiviral Defense Identified
Infectious disease researchers at the University of Georgia have identified a signaling protein critical for host defense against influenza infection.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos