Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

SAW Instruments Enhances Protein Interaction Analysis with the sam®X Acoustic Biosensor

Published: Monday, June 24, 2013
Last Updated: Monday, June 24, 2013
Bookmark and Share
A robust platform for label-free biomolecular assays.

SAW Instruments is continuing to advance acoustic wave biosensor technology with the sam®X platform. Based on SAW’s Surface Acoustic Wave technology, the biosensors measure changes in mass and viscoelasticity at the chip surface based on changes in the high frequency acoustic oscillations running across the chip surface.

This innovative approach is complementary to other biophysical techniques, such as SPR and QCM for measuring protein interactions, and can also be used for samples and applications that are difficult to analyze by these other methods, thus providing additional information and insights.

The sam®X platform is ideally suited to the study of native membrane proteins and protein complexes such as the 7TM G-Protein Coupled Receptors (GPCRs), either as membrane fragments or within liposome or vesicle particles.

Such complexes can be very challenging to analyze by traditional biosensor platforms. For these therapeutically relevant targets, sam®X technology represents a new potential tool for drug discovery programs.

Closely coupled to this, many drug companies are also interested in looking at the separate conformational data from the sam®X platform (i.e. measuring the change in the acoustic wave amplitude) when using small molecule candidates against protein targets or vesicles. This can provide very valuable information on compounds whose binding induces structural changes in their targets.

In terms of practical workflow improvement and benefits, the eight channels of the dual-chip sam®X system provide more sensors for a higher throughput, and perhaps even more importantly, provide flexible fluidic channel routing which allows different samples or reagents to be delivered to discrete channels or combinations of channels on the chip.

Different proteins can also be immobilized at separate sensor position while the chip is on-line, enabling loading of the surface to full capacity, and allowing for a degree of quantification, which vastly improves data quality and assists interpretation.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

SAW Instruments Expands Presence in the US
Company has further expanded its presence in the USA by forming a new subsidiary, SAW Instruments USA, LLC, and recruiting a full time Field Application Scientist based in Boston, MA.
Monday, March 19, 2012
Scientific News
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
Genomic Signature Shared by Five Types of Cancer
National Institutes of Health researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
Protein Protects Against Flu in Mice
The engineered molecule doesn’t provoke inflammation and may hail a new class of antivirals.
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Natural Protein Points to New Inflammation Treatment
Findings may offer insight to effective treatments for inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Enzyme Links Age-Related Inflammation, Cancer
Researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration.
New Biomarker to Assess Stem Cells Developed
A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). The team's discovery offers a new way to fast-track screening methods used in stem cell research.
Scroll Up
Scroll Down
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!