Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

WHEATON® Offers a Turnkey Solution for CHO Cell Bioproduction

Published: Wednesday, August 07, 2013
Last Updated: Wednesday, August 07, 2013
Bookmark and Share
WHEATON® CELLine™ Bioreactor combined with an optimized CHO medium formulation by Irvine Scientific expedites small-scale antibody and protein production.

WHEATON® and Irvine Scientific have collaborated to introduce a high yield, small-scale solution for bioproduction. The solution consists of a WHEATON® CELLine™ bioreactor flask paired with Irvine Scientific’s BalanCD™ CHO Growth A animal component-free, chemically-defined medium.

Scientists may now quickly set up and perform small-scale antibody and protein production while decreasing the cost per milligram produced. This bundled product is available now from WHEATON® and its extensive distributor network.

Antibodies and proteins for research and therapeutic purposes are typically produced in a modified cloned cell. The most widely used cells for in vitro production methods are Chinese Hamster Ovary (CHO) cells due to their stable gene expression, rapid growth, high protein production rate, and rich background of published data.

The combination of a high-throughput bioreactor, an optimized medium formulation, and an easy to follow protocol for cultivating CHO cells, provides a highly productive development platform.

WHEATON® CELLine™ Bioreactors provide an ideal growth environment for high-density cell cultures.

Cells are separated from the bulk growth medium by a dialysis membrane that regulates the flow of nutrients and waste products to and from the cell chamber.

The lower side of the cell chamber is made of a gas permeable membrane allowing continuous exchange of oxygen and carbon dioxide promoting high-density cultures.

CELLine™ bioreactor increases overall yields, and reduces use of consumables and production costs.

Irvine Scientific, a large-scale producer of advanced cell culture media, developed BalanCD™ CHO Growth A medium for optimum CHO cell growth and production.

This particular formulation, in combination with the CELLine™ bioreactor, yields antibody levels higher than conventional methods without the use of a mechanical shaker or agitation.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

WHEATON® Announces Acquisition of CELLine™
WHEATON has acquired the CELLine bioreactor flask line for antibody and protein production from Wilson Wolf Manufacturing Corporation.
Tuesday, July 10, 2012
Scientific News
Key to Natural Detoxifier’s Reactivity Discovered
Results have implications for health, drug design and chemical synthesis.
New Protein Found in Immune Cells
Immunobiologists from the University of Freiburg discover Kidins220/ARMS in B cells and demonstrate its functions.
Cell's Waste Disposal System Regulates Body Clock Proteins
New way to identify interacting proteins could identify potential drug targets.
How a Molecular Motor Untangles Protein
Diseases such as Alzheimer’s, Parkinson’s and prion diseases, all involve “tangled” proteins.
Compound Doubles Up On Cancer Detection
Researchers have found that tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer.
How Cell Growth Triggers Cell Division
Researchers in Jan Skotheim's lab have discovered a previously unknown mechanism that controls how large cells grow, an insight that could one day provide insight into attacking diseases such as cancer.
Probing the Forces Involved in Creating The Mitotic Spindle
Scientists at The Rockefeller University reveal new insights into the mechanical forces that govern elements of the mitotic spindle formation.
Identifying Cancer’s Food Sensors May Help to Halt Tumour Growth
Oxford University researchers have identified a protein used by tumours to help them detect food supplies. Initial studies show that targeting the protein could restrict cancerous cells’ ability to grow.
Specific Variations in RNA Splicing Linked to Breast Cancer
Researchers have identified cellular changes that may play a role in converting normal breast cells into tumors. Targeting these changes could potentially lead to therapies for some forms of breast cancer.
Thousands of Protein Interactions Identified
Thanks to the work by Utrecht University researcher Fan Liu and her colleagues, it is now possible to map the interactions between proteins in human cells.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos