Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

High Levels of RANK Protein Interferes with the Differentiation of Mammary Cells

Published: Wednesday, September 11, 2013
Last Updated: Wednesday, September 11, 2013
Bookmark and Share
Levels of this protein increase with age, which could explain the increase in breast cancer risk associated with age.

Researchers of the Transformation and Metastasis research group at Bellvitge Biomedical Research Institute (IDIBELL), led by Eva González-Suárez, have shown that overexpression of RANK signalling pathway interferes with the differentiation of the cells that form the mammary glands. This produces an accumulation of undifferentiated cells that finally leads to tumor development.

In previous studies, the laboratory of Eva Gonzalez-Suarez had already demonstrated that over activation of RANK signalling pathway promotes the initiation, progression and metastasis of tumors in breast epithelial cells.

In this article, published in the journal Stem Cells, researchers have extensively studied the role of RANK in the differentiation of breast cells from a transgenic mouse model that presents an over activaton of this pathway.

Mammary cell lineages

In a non-transgenic mouse, with normal levels of RANK, the cells of the ducts (tubes where circulates milk in the mammary glands) are differentiated into two lineages: the luminal cells that are oriented to the lumen of the duct and basal cells of lining.

"The two cell populations are well separated and tidy" explained Eva González-Suárez "but in genetically modified animals with high levels of expression of RANK was observed several abnormalities affecting the morphology: ducts are disorganized, do not form continuous layers of cells and they are not oriented as they should. "

Using various techniques, researchers have demonstrated that mice with overactivation of RANK pathway accumulate breast stem cells that have not differentiated cells with basal and luminal characteristics, ie intermediate progenitor cells that have not performed the differentiation process. "This accumulation" said Gonzalez-Suarez, "leads to the development of heterogeneous tumors."

The study also shows that in the unmodified mice as they age and after many pregnancies, naturally levels of RANK increase, which could explain that with age increases the risk of breast cancer.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

A Gene Conserved from Worms to Humans Opens the Door to new Therapeutics
Gene shows promising therapeutic strategies in cancer and in some types of blindness.
Friday, June 21, 2013
Identified a Key Protein in Maintaining the Identity of B Lymphocytes
This finding could be useful for the study of blood diseases such as lymphoma and leukemia.
Monday, June 10, 2013
Ángel Carracedo: ''Only 50% of First-Line Drugs are Effective''
The Professor of Legal Medicine and director of the Genomic Medicine lab at the University of Santiago de Compostela, talked of the future challenges of the field of pharmacogenetics in the clinic.
Wednesday, March 20, 2013
Scientific News
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
HIV Particles Used to Trap Intact Mammalian Protein Complexes
Belgian scientists from VIB and UGent developed Virotrap, a viral particle sorting approach for purifying protein complexes under native conditions.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
Computational Model Finds New Protein-Protein Interactions
Researchers at University of Pittsburgh have discovered 500 new protein-protein interactions (PPIs) associated with genes linked to schizophrenia.
New Insights into Gene Regulation
Researchers have solved the three-dimensional structure of a gene repression complex that is known to play a role in cancer.
Controlling RNA in Living Cells
Modular, programmable proteins can be used to track or manipulate gene expression.
Soy Shows Promise as Natural Anti-Microbial Agent
Soy isoflavones and peptides may inhibit the growth of microbial pathogens that cause food-borne illnesses, according to a new study from University of Guelph researchers.
Potential Target for Revolutionary Antibiotics
An international team of including the Lomonosov Moscow State University researchers discovered which enzyme enables Escherichia coli bacterium (E. coli) to breathe.
DNA Barcodes Gone Wild
A team of researchers at University of Toronto’s Donnelly Centre and Sinai Health System’s Lunenfeld-Tanenbaum Research Institute (LTRI) has developed a new technology that can stitch together DNA barcodes inside a cell to simultaneously search amongst millions of protein pairs for protein interactions.
Biomarkers for Profiling Prostate Cancer Patients
Exiqon A/S has announced the publication of validation of prognostic microRNA biomarkers for the aggressiveness of prostate cancer in independent cohorts.
Scroll Up
Scroll Down
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!