Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

New European Study will Devise Ways to Reduce the Side-Effects of Radiotherapy

Published: Monday, September 16, 2013
Last Updated: Monday, September 16, 2013
Bookmark and Share
Scientists aim to reduce the unwanted side-effects of radiotherapy and improve cancer treatment.

The research, funded by the European Union and involving 13 institutions in the UK, France, Germany, Belgium, Italy, Spain, The Netherlands and the US, will identify ways to predict which breast, prostate and lung cancer patients are most likely to suffer long-term side effects.

These findings will then be used to design trials that test if cancer treatment can be tailored more specially to individuals so that the worse side effects of radiation – such as bowel or bladder incontinence can be avoided.

There are 17.8million people living in the European Union with a diagnosis of cancer and seven million of these people might receive radiotherapy - a treatment that involves the use of high-energy radiation to kill cancer cells.

In the long-term around 20% of those suffering with mild to severe side-effects – 1.4 million people – could benefit from the improvements the study brings.

Professor Catharine West, Professor of Radiation Biology at The University of Manchester’s Institute of Cancer Sciences who is leading the £5million study, said: “Long-term side-effects of radiotherapy impact on the quality-of-life of cancer survivors.

“Earlier work has identified clinical and biological predictors but more work and a better co-ordinated approach is needed to validate these findings so that they can be used in hospitals when treating patients.

“The study, known as REQUITE, aims to develop new clinical models and incorporate biomarkers to identify, before treatment, cancer patients at risk of side-effects. We can then use these models to design interventional trials aimed at reducing side-effects and improving quality of care in cancer survivors who undergo radiotherapy.”

The five-year study, which gets underway next month, is the first major grant won by members of the Radiogenomics Consortium, a collaboration set up in 2009 to work on projects identifying the common genetic variations that influence a cancer patient’s likelihood of developing side-effects from radiotherapy. REQUITE includes a four year observational study of cancer patients undergoing radiotherapy across Europe, US and in the UK, including The Christie NHS Foundation Trust. Patients will each give a blood sample, from which DNA will be extracted and genotyped to identify genetic variation. Scientists can then look at this variation in terms of the side effects experienced by the patient and use this information to confirm and/or improve current models that try to predict a patient’s response to radiotherapy. In the future this type of research could reduce side effects for all radiotherapy patients, improve quality of life and potentially increase the number of patients successfully treated for their cancer.

Professor West, who is also part of the Manchester Cancer Research Centre, a partnership between The University of Manchester, The Christie and Cancer Research UK, added:

“Radiotherapy can damage healthy normal tissues which causes side-effects, most are short-lived getting better within a few days or weeks of treatment and might include sore skin, tiredness and hair loss but some can appear months to years following treatment.

“The side-effects can have a long-term impact on quality of life such as if people feel unable to leave their homes for fear of incontinence.”

Dr Susan Davidson will run the study at The Christie. Dr Davidson said: “The research will play a role in the long-term goal to make cancer treatment more personalised to individuals. This study should mean that in future doctors can look at a patient’s biomarkers by taking a blood test and design their treatment accordingly. We will begin recruiting patients to this study when it opens in April 2014.”

Professor West added: “This focus on personalised medicine is one of the key things the new Manchester Cancer Research Centre is working hard to do – bringing together a wide range of expertise to revolutionise cancer treatment. By collaborating with specialist partners in Europe and the US, this study we will be the largest of its kind and should provide the clearest picture yet about how different people respond to radiotherapy.”

The University of Manchester team will be working with Dr Chris Talbot from the University of Leicester who is the deputy project lead.

Dr Talbot said: "I hope that the project will construct a statistical model, including biological marker data, to predict which patients with lung, breast or prostate cancers are at risk of serious adverse reactions to radiotherapy.

"This is an important area because as survival from cancer increases more people are living with side effects of treatment. Anything we can do to lower side effects by personalising the treatment to the individual has the potential to improve quality-of-life for cancer survivors.

"In future, cancer treatments will be optimised for each individual and their particular tumour, so that survival is optimised and side effects are minimised."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
NIH Supports New Studies to Find Alzheimer’s Biomarkers in Down Syndrome
Initiative will track dementia onset, progress in Down syndrome volunteers.
Dementia Linked to Deficient DNA Repair
Mutant forms of breast cancer factor 1 (BRCA1) are associated with breast and ovarian cancers but according to new findings, in the brain the normal BRCA1 gene product may also be linked to Alzheimer’s disease.
How Cells ‘Climb’ to Build Fruit Fly Tracheas
Mipp1 protein helps cells sprout “fingers” for gripping.
A Cellular Symphony Responsible for Autoimmune Disease
Broad Institute researchers have used a novel approach to increase our understanding of the immune system as a whole.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Gut Microbes Signal to the Brain When They're Full
Don't have room for dessert? The bacteria in your gut may be telling you something.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos