Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Global Study Discovers Flurry of New Alzheimer’s Genes

Published: Wednesday, October 30, 2013
Last Updated: Wednesday, October 30, 2013
Bookmark and Share
An international study has uncovered 11 new genes that increase the chance of developing Alzheimer’s disease and provide new clues to ways of fighting it.

The study, which examined close to 75,000 people in 15 countries, doubles the number of known genes that increase Alzheimer’s risk in the elderly. “The international group identified as many new genes in this one study as have been found over the last 15 years combined,” says one of the study’s senior authors, Richard Mayeux, MD, chair of neurology at Columbia University Medical Center.

The study, which is being published in the Nov. issue of Nature Genetics, was conducted by dozens of researchers through the International Genomics of Alzheimer’s Project (IGAP), created in 2011.

None of the 11 new genes has as strong an  effect on Alzheimer’s as the APOE4 gene, which was linked to the disease in the 1990s. APOE4 accounts for about 20 percent of cases, while the strongest of the new genes accounts for, at most, 8 percent of cases.

The significance of the discovery lies instead in the number of possible new drug targets revealed by the study, including some that are involved in processes never before considered in Alzheimer’s.

“Six of our new genes suggest the existence of new pathways underlying Alzheimer’s,” Mayeux says. These areas include the junction between neurons in the hippocampus, the area of the brain where Alzheimer’s begins, and the activity of other cells in the brain surrounding the neurons.

Other new genes uncovered by the group are related to processes in the brain that are well-known contributors to Alzheimer’s, including the processes that lead to the build-up of toxic amyloid beta and tau deposits, or help confirm newer ideas such as inflammation. The identification of new genes involved in these processes may ultimately lead to new drugs.

What’s most needed now, the investigators say, is an intense effort to understand the precise roles of all 22 genes in the development of Alzheimer’s disease.

“At the end of the day, we want to find a way to halt or prevent the disease,” Mayeux says.  “The prospects of doing this are now somewhat greater, but we still have a lot of work to do.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Can We Break the Link Between Obesity and Diabetes?
Columbia University researchers identify a key molecule involved in the development of type 2 diabetes.
Tuesday, May 31, 2016
Useful Colon Cancer Biomarker Discovered
Biomarker is detectable with simple, inexpensive test.
Monday, January 25, 2016
Long-term Memories Are Maintained by Prion-like Proteins
Research from Eric Kandel’s lab at Columbia University Medical Center has uncovered evidence of a system in the brain that persistently maintains memories for long periods of time.
Friday, July 03, 2015
Study Shows Where Alzheimer’s Starts and How It Spreads
The findings could improve early detection of the disease, when drugs may be most effective.
Tuesday, December 24, 2013
Test Could Identify Which Prostate Cancers Require Treatment
3-gene biomarker gauges tumor’s aggressiveness.
Thursday, September 12, 2013
Improper Protein Digestion in Neurons Identified as a Cause of Familial Parkinson’s
Researchers at CUMC and others have discovered how the most common genetic mutations in familial Parkinson’s disease damage brain cells.
Friday, March 08, 2013
Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
Designing Drugs with a Whole New Toolbox
Researchers develop methods to design small, targeted proteins with shapes not found in nature.
Protein Studies Discover Molecular Secrets
Two protein studies have mapped proteins that reveal the secrets to recycling carbon and healing cells.
Tapping Evolution to Improve Biotech Products
Researchers show how 'ancestral sequence reconstruction' can be used to guide engineering of a blood clotting protein.
New Weapon Against Hard-to-Treat Bacterial Infections
Using peptides, researchers have been able to prevent drug-resistance bacteria from forming abscesses.
Death-or-Repair Switch Protein Identified
Researchers have identified a protein that plays a key role in the decision process of cell damage repair or cellular suicide.
Gene Regulation in Brain May Explain Repetitive Behaviors in Rett Syndrome Patients
The research could be a key step in developing treatments to eliminate symptoms that drastically impair the quality of life in Rett patients.
CES Score May Predict Response to Cancer Treatment
Researchers identify new type of biomarker that helps predict prognosis and response to several types of cancer treatment.
Gene Deletion Reveals Cell Secrets
Researchers have deleted 174 genes in yeast to analyse the effect of individual gene deletion.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!