Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Labcyte Receives $1 Million NCI Award

Published: Friday, November 22, 2013
Last Updated: Friday, November 22, 2013
Bookmark and Share
The award will be used to create an innovative process to detect cancer-related proteins in samples, with initial work in breast cancer detection.

The unsurpassed precision and accuracy of Labcyte acoustic liquid handling enables biomarker detection by measuring multiple proteins with a MALDI mass spectrometer.  Recent work with the Canary Center at Stanford, also supported by the National Cancer Institute, showed the ability to achieve the sensitivity required for quantifying very small amounts of proteins associated with ovarian cancer. Measuring the amount of multiple proteins, and at lower cost, is an essential step in developing new diagnostic tools for disease treatment and monitoring.

This cutting-edge process encompasses stable standards and capture of biomarkers with antibodies and expects to achieve greater throughput than traditional liquid chromatography-mass spectrometric approaches.  The utility of this technique will be tested by simultaneously analyzing 16 different biomarkers, run in quadruplicate, to simulate the analysis of 64 unique biomarkers.  The process has the potential to expand to a greater number of biomarkers as well.  It may enable significant advances in diagnostics and discovery.

"I am particularly enthusiastic about participating with Labcyte on the further development of their protein multiplexed biomarker detection platform,” said Dr. Mark Stolowitz, Director of the Proteomics Core Facility at the Canary Center at Stanford for Cancer Early Detection.  “This novel immunoaffinity mass spectrometry based approach exploits MALDI-TOF-MS for detection of proteotypic peptides. The platform affords sensitivity comparable to that of triple-quad mass spectrometers while providing significantly greater throughput and better precision than that obtainable from LC-MS/MS based approaches. Over the next few years, the Labcyte platform should provide the high throughput biomarker verification/validation solution that researchers have sought in conjunction with the emergence of clinical proteomics."

In addition to working with the Canary Center, the Labcyte project includes collaboration with the Fred Hutchinson Cancer Research Center in Seattle, Washington.

“We are excited to work with Dr. Stolowitz to explore the potential advantages of the Labcyte platform to increase the throughput beyond that of existing immuno-MRM assays,” said Dr. Amanda Paulovich, an associate member of the Clinical Research Division at the Fred Hutchinson Cancer Research Center.

“Better identification and quantification of multiple biomarkers are critical tools for researchers and clinicians to fight cancer and a wide variety of other diseases,” said Rich Ellson, CTO of Labcyte.  “The unique, revolutionary aspects of acoustic dispensing are essential for the process. We are eager to work with Dr. Stolowitz and Dr. Paulovich, as this could become fundamental for biomarker development.”

This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institute of Health and Human Services under Contract No. HHSN261201300089C.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Labcyte Secures NIH Funding
The award of $196K from the National Cancer Institute will fund a collaborative cancer biomarker validation program with the Canary Center of Stanford University.
Wednesday, November 09, 2011
Labcyte Awarded 40th US Patent
Patent number 7,717,544 describes how in real time acoustic energy is optimized to transfer a droplet of any fluid.
Wednesday, August 25, 2010
Labcyte Signs Bioscreen Instruments as Exclusive Distributor in India
Labcyte, the developer of acoustic liquid transfer, with systems in all top 10 pharmaceutical companies, today announced the selection of Bioscreen Instruments Pvt. Ltd. as its exclusive distributor in India.
Wednesday, September 23, 2009
Labcyte Awarded Second Japanese Patent
Patent covers the design for acoustics used for cell sorting and transfer.
Wednesday, August 19, 2009
Labcyte Awarded 27th U. S. Patent Describing Acoustic Transfer for the Preparation of Protein Microarrays
This broad patent expands the horizons for protein array preparation.
Thursday, August 17, 2006
Scientific News
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Novel Proteins Linked to Huntington's Disease
University of Florida Health researchers have made a new discovery about Huntington's disease, showing that the gene that causes the fatal disorder makes an unexpected "cocktail" of mutant proteins that accumulate in the brain.
Enzyme Critical to Maintaining Telomere Length Discovered
New method expected to speed understanding of short telomere diseases and cancer.
New Method Identifies Up to Twice as Many Proteins and Peptides
An international team of researchers developed a method that identifies up to twice as many proteins and peptides in mass spectrometry data than conventional approaches.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
New Way to Force Stem Cells to Become Bone Cells
Potential therapies based on this discovery could help people heal bone injuries or set hardware, such as replacement knees and hips.
Long-Sought Protein Sensor for the ‘Sixth Sense’ Discovered
In a study led by scientists from The Scripps Research Institute (TSRI)the sensor protein for propioception has been identified.
How Viruses Commandeer Human Proteins
Researchers have produced the first image of an important human protein as it binds with ribonucleic acid (RNA), a discovery that could offer clues to how some viruses, including HIV, control expression of their genetic material.
Tracking How Herpes Simplex Virus Moves Through Cells
In a recent study, Derek Walsh, PhD, associate professor of Microbiology-Immunology, and his team showed how the herpes simplex virus (HSV) exploits microtubule plus-end tracking proteins to initiate transport and infection in human cells.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos