Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Biomarkers Indicate Increased Risk of Death After Discharge from Cardiac Surgery

Published: Monday, December 23, 2013
Last Updated: Monday, December 23, 2013
Bookmark and Share
Following cardiac surgery, patients with elevated levels of kidney injury biomarkers are at a significantly higher risk of dying during the next three years, a Yale study has found.

An earlier Yale study identified specific blood and urine markers that can predict which patients will suffer acute kidney injury (AKI) after cardiac surgery. AKI is a frequent complication of cardiac surgery, and the Yale investigators demonstrated that biomarkers predicted who is at risk of progressively worsening kidney function immediately after surgery.

The new study examined mortality at an average of three years after cardiac surgery. The researchers found that patients with clinically apparent AKI who also had high levels of urinary biomarkers of kidney injury, particularly interleukin (IL)-18 and kidney injury molecule (KIM)-1, faced a 2- to 3.2-fold increased risk for mortality over three years, compared with patients with the lowest levels of these biomarkers. However, the most interesting finding, say the researchers, was that even patients who have no evidence of clinical AKI, but who do have high levels of these injury biomarkers in their urine were also at higher risk of death.

The researchers believe these findings can provide an important way to assess patients — both with and without clinical AKI — in the immediate postoperative period in order to identify those who are at increased risk of death.

“AKI has traditionally been defined by serum creatinine, which represents changes in kidney function. This is the first study that links structural injury of the kidney with meaningful long-term outcomes,” said senior author Chirag Parikh, M.D., director of the Program of Applied Translational Research and associate professor of nephrology at Yale School of Medicine and the Veterans Affairs Medical Center. “These newer biomarkers of kidney injury, often referred to as the ‘troponins of the kidney,’ have the potential to shape the future definitions and trials of acute kidney injury.”

The Yale researchers, along with those from other institutions in the United States and Canada, are known as the Translational Research Investigating Biomarker End-Points in AKI consortium (TRIBE-AKI), a multidisciplinary group of academic investigators with expertise in pre-clinical, translational, epidemiological, and health services research.

First author is Steven Coca of Yale; other authors are Harlan Krumholz of Yale; Amit Garg, and Heather Thiessen-Philbrook of Western University in London, Ontario; Jay Koyner of the University of Chicago; Uptal Patel of Duke University; and Michael Shlipak of the Veterans Affairs Medical Center at the University of California, San Francisco.

This study was supported by grants from the National Institutes of Health (R01HL085757, K23DK080132, and K24DK090203), and from Abbott Diagnostics, and Sekisui Diagnostics, Inc.

The results appear in the Journal of the American Society of Nephrology.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Type of Drug Can Target All Disease-causing Proteins
Current drugs block the actions of only about a quarter of known disease-causing proteins, but Yale University researchers have developed a technology capable of not just inhibiting, but destroying every protein it targets.
Monday, June 15, 2015
Single-Cell, 42-plexed Protein Analysis Achieved with a New Microchip Technology
A novel microdevice capable of detecting 42 unique immune effector proteins has been developed.
Tuesday, February 17, 2015
Tarantula Venom Holds Hope for New Painkillers
Screening more than 100 spider toxins, Yale researchers identified a protein from the venom of the Peruvian green velvet tarantula that blunts activity in pain-transmitting neurons.
Monday, February 17, 2014
Alzheimer’s Missing Link Found: Is a Promising Target for New Drugs
Researchers have discovered a protein that is the missing link in the complicated chain of events that lead to Alzheimer’s disease.
Monday, September 09, 2013
Lung Disease and Melanoma: a Common Molecular Mechanism?
Researchers have solved a biological mystery about the common genesis of many serious diseases such as asthma and metastatic melanoma.
Monday, September 02, 2013
Yale Nobel Laureate Honored with Connecticut Medal of Science
Thomas Steitz will receive the 2013 Connecticut (CT) Medal of Science, the state’s top prize for technological achievement crucial to economic development.
Monday, April 22, 2013
Bacteria Yield Clues About Why Proteins go Bad in ALS and Alzheimer’s
Scientists are unsure why proteins form improperly and cluster together in bunches, a hallmark of neurodegenerative diseases.
Friday, November 02, 2012
Yale Scientists Find a Way to Make Disease-Causing Proteins Vulnerable to Drugs
Researchers have identified a novel way to design drugs for previously inaccessible proteins.
Friday, July 27, 2012
Yale Scientists Pinpoint Key Ingredient in Fighting Pneumonia
Study shows that a mysterious protein produced by a wide spectrum of living things is crucial in regulating the immune response to the most common form of pneumonia.
Friday, July 20, 2012
Yale Researchers Awarded Grant to Develop Treatment of Williams Syndrome
A $320,000 grant will be utilized to study the elastin gene in order to design new treatments for Williams Syndrome.
Wednesday, October 28, 2009
Researchers Announce that two Proteins have Unexpected Effects on Autoimmune Diseases Such as Lupus
Drugs that target these proteins could be important therapies for autoimmunity.
Wednesday, November 01, 2006
Scientific News
Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
"Dark Side" of the Transcriptome
New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.
Advancing Synthetic Biology
Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.
Structure of Brain Plaques in Huntington's
Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder.
Visualizing a Cancer Drug Target at Atomic Resolution
Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.
Pumpjack" Mechanism for Splitting and Copying DNA
High-resolution structural details of cells' DNA-replicating proteins offer new insight into how these molecular machines function
The Power of Three
Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.
Biomarker for Recurring HPV-Linked Oropharyngeal Cancers
A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
Scroll Up
Scroll Down
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!