Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Insight into the Transport Systems of Cells

Published: Monday, March 24, 2014
Last Updated: Monday, March 24, 2014
Bookmark and Share
The insights into the basic operation of cells was achieved using a combination of advanced live-cell imaging, molecular genetics and quantitative analysis.

Research led by Gero Steinberg, Professor of Cell Biology and Director of the Bioimaging Centre at the University of Exeter, features in both the latest editions of the Journal of Cell Biology 

Professor Steinberg and his colleagues have investigated how cells undertake long range transport within polarised cells, such as those in the nervous system of humans.  Speaking about the research, Professor Steinberg said “ We want to understand how cells can transport and distribute cargo within cells.  This is vital if we are to understand how nerve cells operate, for instance, or how pathogenic fungi are able to cause diseases".

Cells have transport networks composed of long microtubules that act like motorways for long distance transport, which uses special motor proteins to delivery cargo to different parts of cells, such as the nucleus, organelles, or for secretion outside of a cell.  Prof. Steinberg has used the model fungusUstilago mayidis to identify the how motor proteins are regulated so they can carry out transport in opposite directions along microtubules. 

In the latest article, the researchers found that a special protein called ‘Hook’ controls the attachment of two different motors, dynein and kinesin-3, to cargo, thereby controlling the transport direction of the organelles. Hook proteins have previously been implicated in numerous human diseases, but the reason for this was unknown.  The Exeter research now reveals why they are so important in the operation of neurons and cells within the brain.

Speaking about the research, Professor Nick Talbot, Deputy Vice-Chancellor for Research said: “This research is impressive because it integrates the latest advances in bio-imaging so we can look at the operation of motor proteins in living cells in un-paralleled detail.  Prof. Steinberg’s group then collaborate with mathematicians to model the movement and activity of these motors and their key regulators, such as Hook.  It is this combination of skills which allows such important and fundamental new discoveries to be made.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,600+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
Proteins in Blood of Heart Disease Patients May Predict Adverse Events
Nine-protein test shown superior to conventional assessments of risk.
Self-Assembling Protein Shell for Drug Delivery
Made-to-order nano-cages open possibilities of shipping cargo into living cells or fashioning small chemical reactors.
Molecular Map Provides Clues To Zinc-Related Diseases
Mapping the molecular structure where medicine goes to work is a crucial step toward drug discovery against deadly diseases.
Nanoprobe Enables Measurement of Protein Dynamics in Living Cells
Mass. General and Harvard researchers use device to measure how anesthetic affects levels of Alzheimer's-associated proteins.
Diagnosing Systemic Infections Quickly, Reliably
Team develop rapid and specific diagnostic assay that could help physicians decide within an hour whether a patient has a systemic infection and should be hospitalized for aggressive intervention therapy.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
A New Tool Brings Personalized Medicine Closer
Scientists from EPFL and ETHZ have developed a powerful tool for exploring and determining the inherent biological differences between individuals, which overcomes a major hurdle for personalized medicine.
Blood Test That Detects Early Alzheimer’s Disease
A research team, led by Dr. Robert Nagele from Rowan University School of Osteopathic Medicine and Durin Technologies, Inc., has announced the development of a blood test that leverages the body’s immune response system to detect an early stage of Alzheimer’s disease – referred to as the mild cognitive impairment (MCI) stage – with unparalleled accuracy.
‘Missing Tooth’ Hydrogels Handle Hard-to-Deliver Drugs
Rice University’s custom hydrogel traps water-avoiding molecules for slow delivery.
Scroll Up
Scroll Down
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,600+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!