Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Crown Bioscience Passes 1000 Model Mark in PDX Collection for Oncology Drug Discovery

Published: Wednesday, April 23, 2014
Last Updated: Tuesday, April 22, 2014
Bookmark and Share
Size of collection allows for more informed preclinical decision making on prospective drug candidates.

Crown Bioscience, Inc. has announced its HuPrime® PDX (Patient-Derived Xenograft) model collection has now passed the 1,000 individual models mark.

The HuPrime model collection, many of which are maintained ‘in life’, enable drug discovery companies to run Clinical Trial-like studies, or HuTrials™, using human surrogate models in mice. Such a comprehensive and diverse collection of well characterized models offers pharmaceutical and biotech partners a unique tool to improve the selection and development path for promising clinical candidates. This can significantly accelerate research programs, reducing the costs and failure rates of drug candidate development.

Patient-Derived Xenografts (PDX) involve extracting human tumors tissues directly from patients and transplanting them into surrogate immunodeficient mice. These models enable drug development and discovery companies to identify genetic signatures of disease, and discover and validate predictive biomarkers (HuSignature™) via performing human surrogate Phase II-like trials (HuTrials™).

Crown Bioscience has greatly expanded its capacity maintaining hundred of models live and running 10s of large-scale HuTrial™ efficacy studies in parallel, acquiring results in months, as opposed to years, and at a significantly lower cost compared to standard human clinical trials.

In addition to this unique Mouse Clinical Trial capacity, the accumulated HuTrial™ experience together with newly developed trial design and HuSignature™ algorithms, greatly enhances Crown’s ability to help partners obtain vital preclinical information essential to the success of their key clinical trials. By validating efficacy, studying and understanding mechanisms of action and resistance and identifying biomarkers, it is possible to improve the stratification of patient populations that may benefit from treatment regimens before entering the clinic.

Jean-Pierre Wery, President of Crown Bioscience, comments, “Passing the 1,000 model mark is a significant milestone in our mission to deliver the ‘gold standard’ in well-characterized models and services to help reduce the attrition rate of candidate compounds in the clinic, before they enter the clinic. As drug discovery continues to rapidly evolve, there is a growing desire to screen candidates earlier with more patient-relevant disease models. We believe that through using models which more closely reflect the patient situation in the clinic, we can significantly accelerate our client’s research programs by helping them make better informed decisions about which compounds to progress into clinical trials.”

He continues, “Our comprehensive collection of models is continuing to rapidly expand and evolve, supported by our databases which enable our clients to rapidly identify models which best suit their needs. Screening candidates earlier with more patient-relevant disease models is helping improve the selection of candidates that are taken forward into the clinic. Earlier informed decision making and shorter trials are redefining the cost and success rate in drug development and discovery.”

Crown’s unique database of HuPrime models, HuBase™ offers a comprehensive database of genotypic, pharmacological, and clinical data, allowing clients to identify and choose the models that meet their criteria based on gene expression, RNAseq, copy number, response to Standard of Care, and many other criteria.

Crown Bioscience has a global footprint, spanning three major continents in North America, Europe, and Asia Pacific. The company offers a unique collection of ready-to-run, well-validated in vitro and in vivo models, model development expertise, comprehensive drug discovery platforms, and global capacity to help clients quantify the real efficacy and pharmacological profile of their candidates before they move into the clinic.

As the largest supplier of translational oncology services, Crown Bioscience is committed to providing its pharmaceutical and biopharmaceutical customers with specialized techniques and services to help the world-wide research community turn cancer from an incurable into a manageable, chronic disease and discover new targets and therapies in the treatment of metabolic diseases.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Cell's Waste Disposal System Regulates Body Clock Proteins
New way to identify interacting proteins could identify potential drug targets.
How a Molecular Motor Untangles Protein
Diseases such as Alzheimer’s, Parkinson’s and prion diseases, all involve “tangled” proteins.
Compound Doubles Up On Cancer Detection
Researchers have found that tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer.
How Cell Growth Triggers Cell Division
Researchers in Jan Skotheim's lab have discovered a previously unknown mechanism that controls how large cells grow, an insight that could one day provide insight into attacking diseases such as cancer.
Probing the Forces Involved in Creating The Mitotic Spindle
Scientists at The Rockefeller University reveal new insights into the mechanical forces that govern elements of the mitotic spindle formation.
Identifying Cancer’s Food Sensors May Help to Halt Tumour Growth
Oxford University researchers have identified a protein used by tumours to help them detect food supplies. Initial studies show that targeting the protein could restrict cancerous cells’ ability to grow.
Specific Variations in RNA Splicing Linked to Breast Cancer
Researchers have identified cellular changes that may play a role in converting normal breast cells into tumors. Targeting these changes could potentially lead to therapies for some forms of breast cancer.
Thousands of Protein Interactions Identified
Thanks to the work by Utrecht University researcher Fan Liu and her colleagues, it is now possible to map the interactions between proteins in human cells.
Are Changes to Current Colorectal Cancer Screening Guidelines Required?
Editorial suggests more research is needed to pinpoint age to end aggressive screening.
Cell-Cell Repulsion Mystery Solved
University of Basel findings could be important for cancer research.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos