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Integrated Diagnostics Announces $47M Funding

Published: Wednesday, April 30, 2014
Last Updated: Wednesday, April 30, 2014
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Company raises $30.25 million from the closing of its Series B and $17 million in non-dilutive debt financing provided by Life Sciences Alternative Funding LLC.

The financing round was led by Baird Capital and joined by Indi’s (Integrated Diagnostics') existing investors, InterWest Partners and the Wellcome Trust. Indi’s first product, Xpresys™ Lung, is a breakthrough, molecular diagnostic blood test developed to provide physicians with an objective tool to address a major medical dilemma—the management of indeterminate lung nodules. The mixed equity and debt investment will be used to further commercialize Xpresys, which launched in late 2013, and to develop additional proteomic blood tests using Indi’s technology platform.

“Indi’s Series B represents our investors and management’s belief Xpresys Lung has the potential to achieve blockbuster status,” said Albert A. Luderer, Ph.D., chief executive officer, Indi. “Xpresys Lung was designed to aid physicians in managing lung nodules— helping to eliminate unnecessary invasive procedures on benign conditions; enabling payers to improve outcomes and save millions of dollars in unnecessary procedures; and minimizing patient anxiety. We are very excited to welcome our new backers, Baird Capital and Life Sciences Alternative Funding LLC (LSAF). The partners at both firms have long track records of investing in medical diagnostics companies.”

As part of the financing, Michael Liang, Ph.D., partner with Baird Capital’s venture capital group, joins Indi’s board of directors. Indi also announced that Alexandria Venture Investments, the strategic venture arm of Alexandria Real Estate Equities, Inc., has joined the Series B as an investor.

“We are very pleased to help Indi take their early commercial success with Xpresys Lung to the next level,” said Liang. “Indi has taken their innovative proteomic technology and applied it to a massive unmet need: the high costs associated with over-diagnosing lung nodules. Their strategy is a perfect fit for Baird Capital’s focus on investing in companies who produce innovative technologies that address expanding market needs.”

Data from two studies supporting the technology behind Xpresys Lung were published in Science Translational Medicine on October 16, 2013. Click here to access the full study.

“We believe Xpresys Lung will play a significant role in helping physicians more effectively manage lung nodules—and Indi’s technology for blood-based diagnostics has the potential to become an important tool in multiple areas of health care,” said Steve DeNelsky, president, LSAF. “Our aim is to provide non-dilutive capital to outstanding commercial-stage life sciences companies in medical devices and diagnostics. We are delighted to play a role in Indi’s success.”

Today, it is estimated millions of pulmonary nodules are discovered each year; after traditional assessment protocols, which include biopsies and surgeries, most of these nodules are classified as benign. Xpresys Lung allows for the non-invasive assessment of pulmonary nodules in the 8-30 mm size range; traditionally, nodules of this size are associated with significant diagnostic uncertainty. Xpresys Lung provides physicians with objective information to identify nodules with a high probability of being benign, potentially reducing unnecessary invasive procedures that may be risky for the patient and costly to the healthcare system. In developing the test, researchers at Indi followed an innovative strategy: Xpresys Lung is designed only to assist physicians in identifying lung nodules likely to be benign, and is not intended to assist physicians with the identification of lung cancer.

The blood test measures the relative abundance of proteins from multiple pathways associated with lung cancer, using a highly sensitive analytic technique called multiple reaction monitoring mass spectroscopy (MRM-mass spec).


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