Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Scripps Scientists Awarded NIH Grant for Biomarker Studies

Published: Tuesday, May 06, 2014
Last Updated: Tuesday, May 06, 2014
Bookmark and Share
$2.3 million grant awarded to develop new diagnostics for cancer, rheumatoid arthritis, colitis.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded a $2.3 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to develop new technology to diagnose cancer, rheumatoid arthritis and colitis.

Paul Thompson, a TSRI associate professor, will be the primary principal investigator for the four-year study.

“We’ve already identified a number of biomarkers for rheumatoid arthritis that we’re in the process of validating,” Thompson said. “The platform we are developing is faster and more versatile than existing technologies.”

Such biomarkers could allow for better, more individually tailored treatments because they could be used to diagnose and monitor disease progression or remission as patients experience different treatment options.

At the heart of the new study is a unique group of enzymes known as protein arginine deiminases (PAD). An increase in PAD activity has been noted in a number of conditions, such as inflammatory diseases like rheumatoid arthritis as well as cancer and Alzheimer’s disease.

PADs participate in reactions in the body that form the amino acid citrulline in proteins through a process known as citrullination, a modification that can have a significant impact on the structure and function of the modified proteins.

While the exact role of citrullination remains unknown, inhibition of citrullination in animal models, using a compound developed by Thompson, has been shown to alleviate the severity of rheumatoid arthritis, ulcerative colitis, atherosclerosis, lupus, nerve damage and cancer.

In addition to developing biomarkers, the scientists will use the grant to better understand this modification and whether it provides a common link among these disparate diseases.

The number of the grant is 1R01GM110394-01.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Targets for Diabetes, Inflammation Discovered
The Scripps Research Institute and Salk Scientists discover 'outlier' enzymes that could offer new targets to treat diabetes and inflammation.
Tuesday, March 29, 2016
Single ‘Transformer’ Proteins
A new study led by scientists at The Scripps Research Institute (TSRI) and St. Jude Children’s Research Hospital shows how a protein involved in cancer twists and morphs into different structures.
Monday, January 11, 2016
TSRI Team Finds Unique Anti-Diabetes Compound
Scientists from The Scripps Research Institute (TSRI) have deployed a powerful new drug discovery technique to identify an anti-diabetes compound with a novel mechanism of action.
Thursday, December 10, 2015
Protein 'Talks' to Wrong Partners in Cystic Fibrosis
Scientists at The Scripps Research Institute (TSRI) have found evidence that a mutant protein responsible for most cases of cystic fibrosis is so busy “talking” to the wrong cellular neighbors that it cannot function normally and is prematurely degraded.
Monday, December 07, 2015
'Fingerprints' for Major Drug Development Targets
For the first time, scientists from the Florida campus of The Scripps Research Institute (TSRI) have created detailed “fingerprints” of a class of surface receptors that have proven highly useful for drug development.
Friday, December 04, 2015
Long-Sought Protein Sensor for the ‘Sixth Sense’ Discovered
In a study led by scientists from The Scripps Research Institute (TSRI)the sensor protein for propioception has been identified.
Monday, November 16, 2015
TSRI, UC San Diego Launch 'Virtual Cell' Project
Drawing on complementary strengths of two San Diego institutions, The Scripps Research Institute (TSRI) and the University of California, San Diego (UC San Diego) have formed a new consortium with a big mission: to map cells in space and time.
Monday, September 21, 2015
Scientists Solve 40-year Mystery of How Sodium Controls Opioid Brain Signaling
The findings pave way for new therapies for treating pain and mood disorders.
Thursday, January 16, 2014
Scientists Discover a New Type of Protein Modification that May Play a Role in Cancer and Diabetes
Scientists at The Scripps Research Institute (TSRI) have discovered a new type of chemical modification that affects numerous proteins within mammalian cells.
Tuesday, August 06, 2013
Chemists Devise Inexpensive, Benchtop Method for Marking and Selecting Cells
Chemists at The Scripps Research Institute have found an easier way to perform one of the most fundamental tasks in molecular biology.
Wednesday, January 16, 2013
Scientists Discover How Two Proteins Help Keep Cells Healthy
The work has implications for cancer drug development.
Thursday, December 06, 2012
Team Reveals Key Protein Interactions Involved in Neurodegenerative Disease
New study reveals the structure of c-jun-N-terminal kinases (JNK) enzymes.
Thursday, November 15, 2012
Scientists Find Structure of a Protein that Makes Cancer Cells Resistant to Chemotherapy
A research team at the Scripps Research Institute has obtained the first glimpse of a protein that keeps certain substances, including many drugs, out of cells.
Monday, March 30, 2009
Scientific News
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
HIV Particles Used to Trap Intact Mammalian Protein Complexes
Belgian scientists from VIB and UGent developed Virotrap, a viral particle sorting approach for purifying protein complexes under native conditions.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
Computational Model Finds New Protein-Protein Interactions
Researchers at University of Pittsburgh have discovered 500 new protein-protein interactions (PPIs) associated with genes linked to schizophrenia.
New Insights into Gene Regulation
Researchers have solved the three-dimensional structure of a gene repression complex that is known to play a role in cancer.
Controlling RNA in Living Cells
Modular, programmable proteins can be used to track or manipulate gene expression.
Soy Shows Promise as Natural Anti-Microbial Agent
Soy isoflavones and peptides may inhibit the growth of microbial pathogens that cause food-borne illnesses, according to a new study from University of Guelph researchers.
Potential Target for Revolutionary Antibiotics
An international team of including the Lomonosov Moscow State University researchers discovered which enzyme enables Escherichia coli bacterium (E. coli) to breathe.
DNA Barcodes Gone Wild
A team of researchers at University of Toronto’s Donnelly Centre and Sinai Health System’s Lunenfeld-Tanenbaum Research Institute (LTRI) has developed a new technology that can stitch together DNA barcodes inside a cell to simultaneously search amongst millions of protein pairs for protein interactions.
Biomarkers for Profiling Prostate Cancer Patients
Exiqon A/S has announced the publication of validation of prognostic microRNA biomarkers for the aggressiveness of prostate cancer in independent cohorts.
Scroll Up
Scroll Down
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!