Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Sneaky Bacteria Change Key Protein’s Shape to Escape Detection

Published: Wednesday, May 28, 2014
Last Updated: Wednesday, May 28, 2014
Bookmark and Share
Researchers believe that this deeper understanding could help lead to new treatments for bacterial diseases.

Every once in a while in the U.S., bacterial meningitis seems to crop up out of nowhere, claiming a young life. Part of the disease’s danger is the ability of the bacteria to evade the body’s immune system, but scientists are now figuring out how the pathogen hides in plain sight. Their findings, which could help defeat these bacteria and others like it, appear in the Journal of the American Chemical Society.

Linda Columbus and colleagues explain that the bacteria Neisseria meningitidis, one cause of meningitis, and its cousin Neisseria gonorrhoeae, which is responsible for gonorrhea, have key-like proteins that allow them to enter human cells and do their damage. Gonorrhea can be cured, though one type of the responsible bacteria has reached “superbug” status, becoming resistant to known drugs. If meningitis is not treated immediately with antibiotics, it can cause severe disability and death. In a search for new ways to treat these diseases, scientists are looking more closely at how the bacteria sneak around in the body undetected. When someone gets an infection, specific proteins — called antigens — that stud the pathogen’s outer layer usually raise an alarm, and the body’s immune system goes on the attack. But these two kinds of Neisseria bacteria can elude the body’s look-out cells, and Columbus’ team wanted to know how.

They combined two approaches to figure out the architecture of one of the bacteria’s outer proteins that help it gain entry into human cells. They found that the protein’s outer loops that jostle against each other, causing their structure to constantly change. This shape-shifting makes for a kind of camouflage that hides them from the body’s sentinels, at the same time preserving its ability to bind to and enter a person’s cells. This deeper understanding could help lead to new treatments for bacterial diseases, the scientists state.

The article “Structure of the Neisserial Outer Membrane Protein Opa60: Loop Flexibility Essential to Receptor Recognition and Bacterial Engulfment” is published in the Journal of the American Chemical Society and is  available online. 


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Mass Spec Technology Drives Innovation Across the Biopharma Workflow
With greater resolving power, analytical speed, and accuracy, new mass spectrometry technology and techniques are infiltrating the biopharmaceuticals workflow.
One Step Closer to Precision Medicine for Chronic Lung Disease Sufferers
A study led by University of North Carolina at Chapel Hill, and National Jewish Health, has provided evidence of links between SNPs and known COPD blood protein biomarkers.
New Imaging Technique in Alzheimer’s Disease
Study confirms new imaging technique corresponds a higher degree of actual brain changes.
Ancient Eggshell Protein Breaks Through DNA Time Barrier
Fossil proteins from a 3.8million year-old eggshell have been identifed, suggests proteins could give insight into evolutionary tree.
New Weapon Against Hard-to-Treat Bacterial Infections
Using peptides, researchers have been able to prevent drug-resistance bacteria from forming abscesses.
Designing Drugs with a Whole New Toolbox
Researchers develop methods to design small, targeted proteins with shapes not found in nature.
Protein Studies Discover Molecular Secrets
Two protein studies have mapped proteins that reveal the secrets to recycling carbon and healing cells.
Tapping Evolution to Improve Biotech Products
Researchers show how 'ancestral sequence reconstruction' can be used to guide engineering of a blood clotting protein.
Death-or-Repair Switch Protein Identified
Researchers have identified a protein that plays a key role in the decision process of cell damage repair or cellular suicide.
Gene Deletion Reveals Cell Secrets
Researchers have deleted 174 genes in yeast to analyse the effect of individual gene deletion.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!