Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Olink Bioscience Introduces a 92-protein Biomarker Panel

Published: Wednesday, July 02, 2014
Last Updated: Wednesday, July 02, 2014
Bookmark and Share
Proseek® Multiplex Inflammation I 96x96 for inflammatory diseases.

Olink Bioscience has launched Proseek® Multiplex Inflammation I 96x96, a new protein biomarker panel that targets a wide range of inflammatory diseases. This panel complements the existing panels directed against Oncology and Cardiovascular diseases in a growing collection.

Proseek Multiplex Inflammation I 96x96 will be an important tool in the search for new multivariate protein expression patterns that could serve as biomarkers to improve prediction and prognosis of inflammatory diseases, as well as discovery of new drug targets.

Inflammatory mechanisms are involved in many types of diseases where the immune system creates a chronic inflammation often resulting in functional impairment of organs. Rheumatoid arthritis, multiple sclerosis, psoriasis, irritable bowel diseases, and asthma are examples of such diseases.

The inflammatory response also plays a major role in other diseases such as cardiovascular disorders, cancer, diabetes and Alzheimer’s disease. Chronic immune system disorders affect millions of people every year, and there is a great unmet need in predicting the efficacy of treatment options at individual level. It is crucial to find new biomarkers to meet these needs in personalized medicine but also for better healthcare in general through improving diagnostic and prognostic tools.

“With the launch of our next exciting multiplex immunoassay panel we are another step closer to the vision of identifying protein profiles that will change the way we prevent, diagnose and treat diseases. Proseek Multiplex makes anyone with access to biological material able to screen for protein biomarker profiles in an exceptionally efficient way.” says Andrea Ballagi, Chief Operating Officer at Olink Bioscience.

Proseek Multiplex Inflammation I 96x96 is a high throughput multiplex immunoassay that efficiently measures 92 inflammation-related proteins across 96 samples (including controls) simultaneously in only one microliter of serum or plasma. When used in combination with Fluidigm’s Biomark TM HD system, a high throughput real-time PCR platform, it enables researchers to analyze thousands of samples per week, which greatly accelerates the speed of discovery of new protein biomarkers.

“We are very pleased with the initial results obtained with Proseek Multiplex Inflammation I 96x96. We have already found several interesting biomarker candidates and we will now extend our study to compare the results with other available panels. Proseek Multiplex Inflammation I 96x96 is certainly a promising tool for future use in rheumatoid arthritis” say Professor Lars Klareskog and Assoc.Prof. Anca Catrina, Rheumatology clinic and research unit, Karolinska University Hospital and Karolinska Institutet.

The Proseek Multiplex Inflammation I 96x96 panel comprises established inflammatory markers as well as a few proteins with great potential to become new biomarkers for inflammatory disorders. The content of the panel has been designed in close collaboration with experts in various inflammatory disease fields such as rheumatoid arthritis, Crohn’s disease, ulcerative colitis, neuro inflammation, and respiratory diseases. The panel is therefore well suited to elucidating protein expression profiles in clinically relevant samples. Proseek Multiplex Inflammation I 96x96 is the third panel from Olink Bioscience.

Proseek Multiplex is based on the proprietary Proximity Extension Assay (PEA) technology developed by Olink Bioscience. PEA is a homogeneous assay that uses pairs of antibodies equipped with DNA reporter molecules which upon target binding give rise to new DNA amplicons, each ID-barcoding their respective antigens. Cross-reactive events are not detected since the sequence design allows only the correctly matched antibody pairs to give rise to a signal. The amplicons are subsequently quantified by high throughput real-time PCR.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

A New European Consortium to Boost our Understanding of IBD
A multi-modal integrated biomarker study Consortium to increase diagnostic precision in detection of the diseases.
Thursday, May 23, 2013
Olink Bioscience Appoints Sigma-Aldrich as Distributor of Duolink
Olink Bioscience will continue to develop the protein biomarker market.
Friday, May 17, 2013
Olink Bioscience Appoints Simon Fredriksson Ph.D. as Executive Vice President
With the new appointment follow increased responsibilities for global business development and external research collaborations.
Monday, June 20, 2011
Olink Bioscience and Sapphire Bioscience Sign a Distributorship Agreement for the Australian & New Zealand Market
Agreement with Sapphire Bioscience for the distribution of the Duolink® product line in Australia and New Zealand.
Wednesday, April 06, 2011
Olink Bioscience and Pioneer Biomed Sign Distributorship Agreement for the Chinese Market
The agreement covers distribution of Duolink regent kit based on PLA® technology.
Monday, March 08, 2010
Scientific News
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Closing the Loop on an HIV Escape Mechanism
Research team finds that protein motions regulate virus infectivity.
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Gut Microbes Signal to the Brain When They're Full
Don't have room for dessert? The bacteria in your gut may be telling you something.
Turning up the Tap on Microbes Leads to Better Protein Patenting
Mining millions of proteins could become faster and easier with a new technique that may also transform the enzyme-catalyst industry, according to University of California, Davis, researchers.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Measuring microRNAs in Blood to Speed Cancer Detection
A simple, ultrasensitive microRNA sensor holds promise for the design of new diagnostic strategies and, potentially, for the prognosis and treatment of pancreatic and other cancers.
Novel Proteins Linked to Huntington's Disease
University of Florida Health researchers have made a new discovery about Huntington's disease, showing that the gene that causes the fatal disorder makes an unexpected "cocktail" of mutant proteins that accumulate in the brain.
Enzyme Critical to Maintaining Telomere Length Discovered
New method expected to speed understanding of short telomere diseases and cancer.
New Method Identifies Up to Twice as Many Proteins and Peptides
An international team of researchers developed a method that identifies up to twice as many proteins and peptides in mass spectrometry data than conventional approaches.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos