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Pilot Project to Generate Affinity Reagents to Human Proteins Chooses ProteOn Xpr36

Published: Monday, February 02, 2009
Last Updated: Monday, February 02, 2009
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University of Toronto selected the ProteOn to screen for binding affinities of reagents, as part of an international consortium pilot study.

Bio-Rad Laboratories, Inc. announced the University of Toronto selected the ProteOn™ XPR36 protein interaction array system to screen protein-specific affinity reagents, including antibodies and antibody fragments, as part of an international consortium pilot study arranged by the Structural Genomics Consortium (SGC) and Human Proteome Resource Center.

The consortium, whose goal is to systematically generate high quality affinity reagents for exploration of the human proteome, chose the multiplexed surface plasmon resonance (SPR) instrument from Bio-Rad for its ability to screen biomolecular interactions.

"The pilot project will generate a wealth of protein-specific reagents that will require a fast, accurate evaluation of their binding affinities," said Renee LeMaire-Adkins, marketing manager, Protein Interaction Technology, Bio-Rad. "The design of the ProteOn XPR36 is ideal for this purpose as it permits the label-free kinetic analysis of six ligands measured against six analytes for 36 data points per experiment."

The result of a workshop in March 2008, the pilot study seeks to demonstrate the feasibility of a variety of methods to generate better affinity reagents for specific protein targets.

Researchers from around the world will be sending their affinity reagents to the University of Toronto for testing on the ProteOn and results are expected to be published in the first half of 2009. A second workshop will be held in March 2009 where the initial results will be summarized and evaluated.

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