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A modular and stochastic approach to the study of gene circuits using P systems
Romero-Campero FJ, Blakes J, Cao H, Camara M, Krasnogor N.

presented at Genomes to Systems Manchester, UK March 17-19 2008

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Formal informatics and machine learning for more principled systems and synthetic biology
Romero-Campero FJ, Blakes J, Camara M, Willams P, Perez-Jimenez MJ, Krasnogor N

presented at European Conference on Synthetic Biology (ESF-UB Conference in Biomedicine), Sant Feliu de Guixols, Spain, 24-29 November 2007.

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A systems analysis of the AHL Quorum Sensing system in Pseudomonas aeruginosa
Romero-Campero FJ, Blakes J, Camara M, Krasnogor N.

presented at Systems Biology (ESF-UB Conference in Biomedicine), Sant Feliu de Guixols, Spain, 12-17 April 2008

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An Integrated Development Environment for Synthetic Biology Models
Blakes J, Romero-Campero FJ, Twycross J, Cao H, Krasnogor N

presented at European Conference on Synthetic Biology (ECSB) II: Design, Programming and Optimisation of Biological Systems (ESF-UB Conference in Biomedicine), Sant Feliu de Guixols, Spain, 29 March - 03 April 2009

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Necessity of quantum mechanics for predicting binding free energy
Ting Zhou, Danzhi Huang, Amedeo Caflisch

We demonstrate the necessity of quantum mechanics (QM) for predicting binding free energy by comparing the results of the linear interaction energy model with continuum model (LIECE) and the equivalent model with QM (QMLIECE).

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Force Spectroscopy of the Iron Atom in Heme Proteins
J. T. Sage, B M. Leu, T. H. Ching, Y. Zhang, J. E. Straub, J. Zhao, W. Sturhahn, E. E. Alp

Nuclear resonance vibrational spectroscopy (NRVS) selectively reveals the complete vibrational density of states (VDOS) of a Mössbauer probe nucleus within a protein. Frequency moments of the VDOS determine effective force constants for 57Fe at the active sites of cytochrome c (cyt c) and deoxymyoglobin (Mb).

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Resorufin - a lead for a new protein kinase CK2 inhibitor
Iben Skjøth Sandholt1, Birgitte Brinkmann Olsen1, Barbara Guerra1, Olaf-Georg Issinger1, Brigitte Boldyreff2

Screening of a natural compound library led to the identification of resorufin, as a highly selective and potent inhibitor for protein kinase CK2. Out of 52 kinases tested only CK2 was inhibited. The IC50 values determined for the CK2 holoenzymes were 1.5 µM and for the free catalytic subunits ca. 4 µM. In different cancer cell lines treatment with resorufin led to cell death and endogenous CK2 was inhibited.

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The Expression and Activity of MMPs during Zebrafish (Danio rerio) Development
N.D. Harris, D.H. Li, J.Y. Keow, C. Po, A. Hong, K. Herrmann, B.D. Crawford

Recent advances have made the zebrafish an attractive system for studying MMP activity. However, there are few commercially available antibodies against MMPs that are suitable for studies using zebrafish. The objectives of the study presented in the poster were to develop effective immunological reagents for the study of MMPs in zebrafish and to test commercially available narrow-spectrum fluorogenic MMPs substrates in in vivo zymography.

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Potential Use of RNAi on Human Skin
Christine Collin-Djangoné, Florent Sahuc, Béatrice Bertino, Anne de Brugerolle, Jean-Eric Baudouin, Peggy Sextius, Séverine Teluob, Rachid Boulgana, Dmitry Samarsky, Peggy Tailor, Peter Welch and Yann Mahé

We designed highly efficient StealthTM RNAi targeting human tyrosinase with optimum IC50 in the 10-100 pM range. By silencing tyrosinase in melanocytes, we achieved the reconstruction of an artificial epidermis showing a long term lasting (>30 days) inhibition of melanogenesis. Since skin pigmentation can phenotypically be monitored, the use of StealthTM RNAi against tyrosinase on reconstructed pigmented epidermis is a precious tool for the evaluation of delivery vehicles.

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Showing Results 91 - 100 of 154
Scientific News
Blood Test To Diagnose Depression
Test identifies nine blood markers tied to depression; predicts who will benefit from therapy.
Study Aims to Develop Breath Test for COPD
A new clinical iniative, lead by NYU Langone Medical Center, aims to determine a breath test’s effectiveness to identify volatile organic compounds (VOCs) in human breath that are biomarkers of chronic obstructive pulmonary disease (COPD).
Salamander Skin Peptide Promotes Wound Healing in Mice
New research suggests that the peptide tylotoin exerts the promotion of wound healing with epidermal growth factor in a murine model of a full thickness dermal wound.
Marijuana Compound May Offer Treatment for AD
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease.
Quantitative Western Blotting Using Stain-Free Technology
Bio-Rad hosted two seminars at the EB 2014 in which KOLs discussed approaches to improve the accuracy of western blotting quantitation using Bio-Rad’s stain-free technology.
Repressing the Repressors May Drive Tissue-Specific Cancers
Stowers scientists establish Drosophila and mammalian models to study mutations found in pediatric brain tumors.
MU Researchers Discover Protein's Ability To Inhibit HIV Release
TIM-family proteins have the ability to block the release of HIV and other viruses.
Epigenetic Study Bolsters Alzheimer's Understanding
The current study found that chemical modifications to DNA within the ANK1 gene are strongly associated with measures of neuropathology in the brain.
Identification of Psoriatic Arthritis Mediators in Synovial Fluid
This study represents the most comprehensive proteomic analysis of psoriatic arthritis synovial fluid, to date.
GTEx Project to Expand Functional Studies of Genomic Variation
Larger set of human tissues to be analyzed to contribute to a database and tissue bank that researchers can use to study how genomic variants influence gene activity.
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