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Identification and Characterisation of Novel Positive Allosteric Modulators of the Galanin 2 Receptor
Hayley Jones

An HTS against GalR2 was carried out to find novel PAMs to treat neuropathic pain.

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The Longest Way Round is the Shortest Way Home: HTS Assay Development for Complex Multi-domain Protein Kinases
Doris Hafenbrandl, Vanessa Nardese, Maria Cristina Sidoli, Valeria Wanke, Mariantonietta Rubino and Daniele Carettoni

This study strongly supports the possibility to overcome the major bottlenecks in the production of long kinase recombinant forms, in order to perform drug discovery programmes with proteins more closely preserving the structural and functional properties of the native enzymes.

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Enabling Epigenetics Studies from HTS to SAR : A Novel HTRF® Platform to Identify and Characterize Reader Domain Inhibitors
T. Roux1, M. Badol1, N. Douayry1, L. Sergeant1, E.Trinquet1, F. Degorce1, S. Milhas2, S. Betzi2, C. Derviaux2, C. Eydoux3, J. Letienne2, A. Lugari2, Y. Collette2, J-C. Guillemot3 et X. Morelli2

Discover a novel HTRF platform to identify and characterize the vast variety of epigenetic binding domain.

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Artificial Multi-Gene Expression Systems Design Service for Natural Compound Formation and Hetero Protein Complexes
Bernauer, Hubert, Gregor Zipf and Josef Maier

Drug discovery of natural compounds drug development and drug target analyses as well as bioproduction can benefit from artificial genetic systems and constructions. The direction in which genes are to be developed is written in the genomes. Synthesis oriented genomic analyses of codon bias and tRNA adaption analyses are prerequisites for generating adaptive, highly functional genes.

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Validation of a 3-Dimensional Human Liver Microtissue Model for Long-term Hepatotoxicity Studies
Brad Larson1, Stewart Hunt2, Timothy Moeller3, Diana Long4, and Peter Banks1

Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drug commonly used as analgesics and antipyretics, as well as for management of rheumatological disorders. They are one of the most highly prescribed drug families around the world, and consequently, along with antimicrobial agents, are the most frequent causes of druginduced liver injury (DILI) (Bjornsson et al., 2010).

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Characterization of Proteins and Protein Self Association (Oligomerization) with SEC-MALS
Michel Terray, Mark Pothecary

In this poster, a series of proteins and their oligomers were characterized using SEC-MALS with UV and RI detection. The monomer molecular weights are measured and compared with those from column calibration. The molecular weights of their oligomers are also compared with column calibration and the differences explored.

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Identifying Molecular Signatures of Tumors Using Novel Fluorescence Resonance Energy Transfer Networks
Vishwa Nellore, Chris Dwyer

We developed FRET sensors that can detect 125 fluorophores simultaneously. From experimental analyses of over 1200 time-resolved fluorescence signatures on 300 prototypical sensors, we show that the optical responses are highly repeatable and minor variations between FRET networks can be discriminated resulting in a total of 10^375 unique responses in theory.

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Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
Tinghui Li , Susan. Murphy, Kanwarpal Bakshi, Steven LaConte, Zhi Sheng, and Harry Dorn

We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.

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Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
L.K. Jambi1, J.E. Lees1, S.L. Bugby1, B.S. Bhatia1,2, M.S. Alqahtani1, W.R. McKnight1, A.H. Ng3 and A.C. Perkins3

Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging

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Showing Results 61 - 70 of 236
Scientific News
Tiny Heart, Big Promise
Researchers have discovered a new source of cells that can develop into coronary vessels.
Two New and Very Large Classes of RNAs Linked to a Cancer Biomarker Identified
Study shows two new classes of RNAs could play a role in progression of prostate cancer.
DNA Mutations get Harder to Hide
Rice University researchers have developed a method to detect rare DNA mutations with an approach hundreds of times more powerful than current methods.
New Way of Preventing Diabetes-Associated Blindness
Researchers have discovered a potential treatment for the most common cause of lose of vision in working age adults in the U.S.
Researchers Find “Decoder Ring” Powers in microRNA
MicroRNA can serve as a "decoder ring" for understanding complex biological processes, a team of New York Univ. chemists has found.
3D for Top-Down Proteomics: Extra Dimension for More Proteins
Researchers from the University of Wisconsin- Madison have tested the possible applications of adding a "third dimension" to chromatography.
New Sucess in Making All Blood Types Universally Accepted
Researchers have improved the ability of an enzyme to transform any blood type into the universally accepted type O.
Beyond Average
Researchers have created new platforms to genetically barcode tens of thousands of cells at a time allowing unprecedented detail to be uncovered when studying whole tissue samples.
Watching a Protein “Quake”
Scientists, for the first time, have precisely measured a protein’s natural “knee-jerk” reaction to the breaking of a chemical bond—a quaking motion that propagated through the protein at the speed of sound.
Uncovering Mechanisms of Replication in HPV
The study describes two cellular proteins which are key regulators in the replication of Human Papilloma Virus.
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