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Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
L.K. Jambi1, J.E. Lees1, S.L. Bugby1, B.S. Bhatia1,2, M.S. Alqahtani1, W.R. McKnight1, A.H. Ng3 and A.C. Perkins3

Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging

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Side by Side: An Evaluation of 2D vs. 3D Cell Culture for High Throughput Screening in Drug Discovery
Sophie Quick 1,2, Sinead Knight 1, Jon Winter 3

•3D cell culture has the potential to provide a more physiologically relevant model compared to standard tissue culture plastic.
•From a screening perspective the technology offers the possibility of more predictive drug responses but has an increased cost.
•The question: is it possible and, more importantly, is it worthwhile moving towards screening in High Throughput using a 3D model?

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High Throughput Screening in the European Lead Factory
S.P. van Helden, W.H. Rutjes, C.A.A. van Boeckel and J.H.M. van den Broek

This paper describes workflows that have been implemented at the screening centre of the European Lead Factory and presents screening statistics on the first 18 months of operation.

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Use of a Microlitre Digital Liquid Handler for Screening Applications
Joby Jenkins, Gillian Lewis, Wayne Bowen

Digital dispensing offers researchers the most freedom for experimental design and sample placement with each microplate. It makes it relatively simple to plan and execute the most desirable experimental design and not one predicated by manual or automated liquid handling.

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Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method
Sarah Kessel, Eric Sincoff, Olivier Dery, Lori Fitton

3D Tumorspheroid models for improved predictivity in cancer drug discovery.

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Design and Evaluation of High Definition Probe for HPV genotyping Microarray
Sihn Ae Lee, Ah Reum Park, Inyoung Kim, Ji Hyung Lee, and Jongwon Kim

To improve the sensitivity and specificity of the HPV DNA Microarray, we adopted triple oligonucleotide probes for each targets and selected these probes not to have higher similarity of 75% with each others. These triple probes have shown 10 ~ 100 times higher sensitivities with comparable specificities than the conventional HPV DNA microarray of single oligonuclotide probe.

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Gut Microbial Metabolites and Hepatic Xenobiotic Metabolism: A High Throughput Screening Approach
Glynn Martin, James Sidaway, Jonathan Swann

This poster highlights the combination of metabonomics and high throughput screening by the identification of gut microbial metabolites and a screening assay designed to determine their cytotoxicity to liver-like cell cultures.

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Digital PCR to Determine the Number of Transcripts from Single Neurons after Patch-clamp Recording
Nóra Faragó1,2, Ágnes K. Kocsis3, Sándor Lovas3, Gábor Molnár3, Márton Rózsa3, Viktor Szemenyei3, Ágnes Zvara2, Gábor Tamás3, László G Puskás1,2

Whole-cell patch-clamp recording enables detecting electrophysiological signals from neurons, and RNA can be harvested into the patch pipette from the cells.We have optimized a dPCR protocol for determining exact transcript numbers in single neurons after patch-clamp recording by using dPCR based on high-density nanocapillary PCR.

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Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells: High Throughput and High Content Assessment of Cardiac Toxicity and Drug Efficacy by Monitoring Cytosolic Free Calcium Transients
1Kettenhofen R, 1Duenbostell A, 2Niedereichholz T, 3D’Angelo JM, 4Horai H, 5Schwengberg S, 1Bohlen H, 6Licher T"

Introduction of selected, pure human cardiomyocytes derived from induced pluripotent stem cell (hiPSCM) into a calcium transient imaging high throughput screening (HTS) assay to assess cardiotoxicity and drug efficacies.

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Showing Results 61 - 70 of 229
Scientific News
Protein Shake-Up
Researchers use neutron scattering and supercomputing to study shape of a protein involved in cancer.
Scientists Uncover Key Cellular Mechanism Involved in Neurodegeneration and Herpes
The discovery of a protein complex at the heart of cellular transport networks could have broad implications for disease research.
Kidney Cancer Detected Early With Urine Test
Washington University School of Medicine researchers have developed a noninvasive method to screen for kidney cancer by measuring the presence of proteins in the urine.
A Vaccine Against Placental Malaria Made with ExpreS2
ExpreS2ion Biotechnologies’ protein expression technology is ready to start human tests in Germany and Benin.
Protein The Clue To Solving A Darwinian Mystery
Scientists at the University of York provided the key to solving the evolutionary puzzle surrounding that Charles Darwin called the ‘strangest animals ever discovered’.
No Humans Required
Automated tool for tracking proteins and the molecules they interact with in living cells developed.
Milk Protein Comparison Unveils Nutritional Gems For Developing Babies
The study revealed the first comprehensive macaque milk proteome and newly identified 524 human milk proteins.
Day-Night Cycles Linked to Mutations
TSRI scientists show that proteins critical in day-night cycles also protect cells from mutations.
Towards A Blood-Based Test For Diagnosing Alzheimer’s Disease
An effective blood test would be safe, affordable and easy to administer in large groups or in rural areas.
Biofuel Proteomics
Joint BioEnergy Institute Researchers use proteomics to profile switchgrass.
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