Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>Products>This Product

MaxDiscovery™ Human IL-15 ELISA Test Kit

Product Description
The MaxDiscovery™ Human IL-15 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-15 in serum, plasma, and cell culture supernatant. Human interleukin 15 (IL-15) is a protein of 114 amino acids after cleavage of a 48 amino acid signal peptide. An alternative splice form of IL-15 has also been identified with an identical mature sequence, but a shorter signal sequence. Interestingly, the shorter prepeptide is not secreted and may represent a functional intracellular molecule. In addition, a membrane-bound form of IL-15 has also been reported, which may be an important physiological form of the molecule. Human IL-15 has 97% and 73% amino acid sequence identity with simian and mouse IL-15, respectively. Both human and simian IL-15s are active on mouse cells. IL-15 is a novel cytokine that shares many biological properties with IL-2. Originally identified in media conditioned by a monkey kidney epithelial cell line (CVI/EBNA) based on its mitogenic activity on the mouse T cell line (CTLL-2), IL-15 was independently discovered as a cytokine produced by a human adult T-cell leukemia cell line (HuT-102) that stimulated T cell proliferation and was designated IL-T . High-affinity cell surface receptors for IL-15 have been detected on a variety of cells including T cells, B cells, and NK cells as well as on non-lymphoid cells. The IL-15 receptor is composed of three molecules; an IL-15 specific a-chain of 237 amino acids, plus a ß-chain and ?-chain that is shared by the receptor system for IL-2. The a-chain binds IL-15 with high affinity. It shows 54% amino acid sequence identity with mouse IL-15 R and exists in multiple alternatively spliced forms. Although the IL-15 receptor is composed of 3 chains, IL-15 will signal through a dimer and the ß?-chain itself may have multiple functions. IL-15 has biological activities similar to IL-2 and has been shown to stimulate the growth of natural killer cells, activated peripheral blood T lymphocytes, tumor infiltrating lymphocytes (TILs), and B cells. In addition, IL-15 has also been shown to be a chemoattractant for human blood T lymphocytes and to induce both lymphokine-activated killer (LAK) activity in NK cells and the generation of cytolytic effector cells. IL-15 apparently also has effects on cells not involved in immune responses. Skeletal muscle cells express IL-15 and IL-15 R mRNAs and respond to the addition of IL-15.
Product MaxDiscovery™ Human IL-15 ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2122-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122

Scientific News
How Cell Growth Triggers Cell Division
Researchers in Jan Skotheim's lab have discovered a previously unknown mechanism that controls how large cells grow, an insight that could one day provide insight into attacking diseases such as cancer.
Probing the Forces Involved in Creating The Mitotic Spindle
Scientists at The Rockefeller University reveal new insights into the mechanical forces that govern elements of the mitotic spindle formation.
Identifying Cancer’s Food Sensors May Help to Halt Tumour Growth
Oxford University researchers have identified a protein used by tumours to help them detect food supplies. Initial studies show that targeting the protein could restrict cancerous cells’ ability to grow.
Specific Variations in RNA Splicing Linked to Breast Cancer
Researchers have identified cellular changes that may play a role in converting normal breast cells into tumors. Targeting these changes could potentially lead to therapies for some forms of breast cancer.
Thousands of Protein Interactions Identified
Thanks to the work by Utrecht University researcher Fan Liu and her colleagues, it is now possible to map the interactions between proteins in human cells.
Are Changes to Current Colorectal Cancer Screening Guidelines Required?
Editorial suggests more research is needed to pinpoint age to end aggressive screening.
Cell-Cell Repulsion Mystery Solved
University of Basel findings could be important for cancer research.
Assessing Cancer Patient Survival and Drug Sensitivity
RNA editing events another way to investigate biomarkers and therapy targets.
New Molecular Marker for Killer Cells
Cell marker enables prognosis about the course of infections.
Controlling Body Temperature in Response to 'Fight or Flight'
New research in The FASEB Journal suggests that blocking TRPV1 protein causes an increased release of noradrenaline, leading to an increase in core body temperatures.
Scroll Up
Scroll Down

Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos