Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>Products>This Product
  Products


MaxDiscovery™ Human IL-17 ELISA Test Kit

Product Description
The MaxDiscovery™ Human IL-17 ELISA Test Kit is designed for quantitative determination of the concentration of human IL-17 in serum, plasma, and cell culture supernatant. Human interleukin 17 (IL-17) is a disulfide-linked homodimer with each ~ 17.5 kDa polypeptide of 136 amino acids (predicted mass = 17.5 kDa) after cleavage of a signal sequence of 19 amino acids. It contains six cysteines plus one potential N-linked glycosylation site, which is variably glycosylated, at least with recombinant proteins. It shares 63% and 58% sequence identity to those of mouse and rat, respectively and 72% identical to the thirteenth ORF of Herpesvirus saimiri. Originally identified as mouse cytotoxic T lymphocyte-associated antigen-8 (CTLA-8), IL-17 is produced by activated memory T lymphocytes. IL-17 appears to mediate communication between the immune system and the hematopoietic system. There is at least some species specificity for in vitro action on bone-marrow stromal cells. The IL-17 receptor (IL-17 R) from the mouse has been characterized. It is a 120 kDa type I transmembrane glycoprotein. There is neither an Ig-like domain nor the WSXWS motif of hematopoietin receptors in the 291 amino acid extracellular segment of the receptor, and there is no identifiable tyrosine kinase domain in the 521 residue cytosolic region. There are, however, serine-rich regions similar to those in IL-2 Rß, IL-4 R and G-CSF R. Thus, the receptor appears to be related to class I cytokine receptors. Based on cell line studies, IL-17 R is expressed by mast cells, fibroblasts, fetal hepatocytes, pre-B cells, and intestinal epithelial cells. It has been reported that IL-17 mediated T cell communication with the hematopoietic system. T cell-derived IL-17 induces fibroblasts to produce IL-6, IL-8, ICAM-1 and G-CSF, apparently by an NF-?B-mediated mechanism. IL-6 in turn promotes development of granulocyte/macrophage colonies, and G-CSF directs development of neutrophils. IL-17 also enhances proliferation of partially activated T cells and upregulates nitric oxide (NO) production in osteoarthritic cartilage. Selected Citations: Akhtar N., Verma, K. K., Sharma A. (Oct 2010) Study of pro- and anti-inflammatory cytokine profile in the patients with parthenium dermatitis Contact Dermatitis 63 (4): 203 – 208. Akhtar, N. et al (Dec 2010)Dysregulation of TH type cytokines in the patients of Parthenium induced contact dermatitis. Clinica Chimica Acta, 411 (23-24): 2024 - 2028.
Product MaxDiscovery™ Human IL-17 ELISA Test Kit
Company BIOO Scientific - Product Directory
Price Request a quote
More Information View company product page
Catalog Number 2124-01
Quantity 1 x 96 wells
Company Logo

BIOO Scientific - Product Directory
3913 Todd Lane Suite 312 Austin, TX 78744, USA

Tel: +1 512-707-8993
Fax: +1 512-707-8122
Email: info@biooscientific.com



Scientific News
Cellular Contamination Pathway for Heavy Elements Identified
Berkeley Lab scientists find that an iron-binding protein can transport actinides into cells.
Lemon Juice and Human Norovirus
Citric acid may prevent the highly contagious norovirus from infecting humans, scientists discovered from the German Cancer Research Center.
Signature of Microbiomes Linked to Schizophrenia
Studying microbiomes in throat may help identify causes and treatments of brain disorder.
Structural Discoveries Could Aid in Better Drug Design
Scientists have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output.
Protein Found to Play a Key Role in Blocking Pathogen Survival
Calprotectin fends off microbial invaders by limiting access to iron, an important nutrient.
Study Identifies the Off Switch for Biofilm Formation
New discovery could help prevent the formation of infectious bacterial films on hospital equipment.
How DNA ‘Proofreader’ Proteins Pick and Edit Their Reading Material
Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have discovered how two important proofreader proteins know where to look for errors during DNA replication and how they work together to signal the body’s repair mechanism.
Protein Found to Control Inflammatory Response
A new Northwestern Medicine study shows that a protein called POP1 prevents severe inflammation and, potentially, diseases caused by excessive inflammatory responses.
X-ray Laser Experiment Could Help in Designing Drugs for Brain Disorders
Scientists found that when two protein structures in the brain join up, they act as an amplifier for a slight increase in calcium concentration, triggering a gunshot-like release of neurotransmitters from one neuron to another.
Team Identifies Structure of Tumor-Suppressing Protein
An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN.
Scroll Up
Scroll Down

Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!