Evotec offers unique proteomics services to address key issues in drug and biomarker discovery. The Company continuously advances its capabilities in mass spectrometry-based proteomics to ensure unrivalled comprehensiveness and data quality when analysing cells, animal models and patient samples.
The Company’s offering includes:
Highly optimised experimental strategies tailored to different proteomics applications and project needs
Industry-leading capabilities in high-end quantitative mass spectrometry
Experience and infrastructure to analyse the enormous amounts of data generated in large-scale proteomics projects
Advanced statistics and bioinformatics for systems-wide data analysis
In-depth data interpretation to extract relevant drug target and mode-of-action information from proteomics experiments
Extensive track record to deliver high-quality results within agreed timelines
Evotec’s chemical proteomics technologies such as Cellular Target Profiling® reveal cellular drug targets and selectivity in an unbiased manner. Other Evotec proteomics technologies record protein modification and expression on a proteome-wide scale for drug mode-of-action analysis or biomarker discovery efforts. Thus, the Company’s platform offers highly innovative solutions that can be leveraged across the entire drug discovery and development pipeline.
Retractable Protein Nanoneedles The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.A Crystal Clear View of Biomolecules Fundamental discovery triggers paradigm shift in crystallography.Charting Kidney Cancer Metabolism Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy."Dark Side" of the Transcriptome New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.Advancing Synthetic Biology Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.Structure of Brain Plaques in Huntington's Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder. Visualizing a Cancer Drug Target at Atomic Resolution Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.Pumpjack" Mechanism for Splitting and Copying DNA High-resolution structural details of cells' DNA-replicating proteins offer new insight into how these molecular machines functionThe Power of Three Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.Biomarker for Recurring HPV-Linked Oropharyngeal Cancers A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.