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ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.
New Cancer Drug Target Found in Dual-Function Protein
Findings from a study from TSRI have shown that targeting a protein called GlyRS might help to halt cancer growth.
HIV Structure Stabilized
Findings represent ‘big accomplishment’ in biomedical engineering and design.
New Cancer Drug Target in Dual-Function Protein
Scientists at The Scripps Research Institute (TSRI) have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients.
“Amazing Protein Diversity” Discovered in Maize
The genome of the corn plant – or maize, as it’s called almost everywhere except the US – “is a lot more exciting” than scientists have previously believed. So says the lead scientist in a new effort to analyze and annotate the depth of the plant’s genetic resources.
Proteins in Blood of Heart Disease Patients May Predict Adverse Events
Nine-protein test shown superior to conventional assessments of risk.
Self-Assembling Protein Shell for Drug Delivery
Made-to-order nano-cages open possibilities of shipping cargo into living cells or fashioning small chemical reactors.
Molecular Map Provides Clues To Zinc-Related Diseases
Mapping the molecular structure where medicine goes to work is a crucial step toward drug discovery against deadly diseases.
Nanoprobe Enables Measurement of Protein Dynamics in Living Cells
Mass. General and Harvard researchers use device to measure how anesthetic affects levels of Alzheimer's-associated proteins.
Diagnosing Systemic Infections Quickly, Reliably
Team develop rapid and specific diagnostic assay that could help physicians decide within an hour whether a patient has a systemic infection and should be hospitalized for aggressive intervention therapy.
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microRNA Microarray Service
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This month researchers at the Department of Biological Sciences at the University of Lethbridge published the latest in a series of papers describing characterization of breast cancer using microRNA expression profiling and epigenomic and proteomic measurements in rat model.

“Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications and Aberrant MicroRNA Expression” by Kovalchuk and co-workers

One most important outcome of the current study is the first time demonstration of miRNA expression in mammary tissue correlates with epigenetic dysregulation manifested in morphological changes and alteration of DNA methylation and histone methylation. In particular, using miRNA microarray analysis (provided by LC Sciences) of the E2-induced carcinogenesis development in rat, the down‑regulated miR‑22, miR‑99a, miR‑99b, and miR‑127 are shown to correlate with elevated target oncogene activities.  In this series of studies of the three main components of epigenetics, the authors concluded that “Changes in DNA and histone methylation, and, importantly, deregulation in the miRNAome may lead to the emergence of epigenetically reprogrammed cells with a tumor‑specific phenotype (inhibition of cell cycle arrest and apoptosis, activation of cell proliferation) leading to subsequent malignant transformation”.

LC Sciences pioneered miRNA microarray service and continues to be the leader in providing the most current miRNA probe content for miRNA expression profiling.  We currently offer the only comprehensive microRNA microarray service available with probe content of all species from Release 10.0 of the miRBase sequence database. The service package provided by LC Sciences has been developed and extensively used in thousands of successful experiments for addressing the questions in miRNA research.  Our results are proven to be of highest quality, reliable, relevant to related biological studies. In addition to standard public released miRNAs, LC Sciences offers fully customizable microarray products for detection and profiling of other types of regulatory RNAs, including ncRNAs and viral RNAs.



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