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Sorting Through Cellular Statistics
Aaron Dinner, professor in chemistry, and his graduate student Herman Gudjonson are trying to read the manual of life, DNA, as part of the Dinner group’s research into bioinformatics—the application of statistics to biological research.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
The Genetic Roots of Adolescent Scoliosis
Scientists at the RIKEN Center for Integrative Medical Sciences in collaboration with Keio University in Japan have discovered a gene that is linked to susceptibility of Scoliosis.
HIV Susceptibility Linked to Little-Understood Immune Cell Class
High levels of diversity among immune cells called natural killer cells may strongly predispose people to infection by HIV, and may be driven by prior viral exposures, according to a new study.
New Tech Enables Epigenomic Analysis with a Mere 100 Cells
A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer has been developed by researchers at Virginia Tech.
TOPLESS Plants Provide Clues to Human Molecular Interactions
Scientists at Van Andel Research Institute have revealed an important molecular mechanism in plants that has significant similarities to certain signaling mechanisms in humans, which are closely linked to early embryonic development and to diseases such as cancer.
Toxin from Salmonid Fish has Potential to Treat Cancer
Researchers from the University of Freiburg decode molecular mechanism of fish pathogen.
Study Finds Non-Genetic Cancer Mechanism
Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found.
Long-sought Discovery Fills in Missing Details of Cell 'Switchboard'
A biomedical breakthrough reveals never-before-seen details of the human body’s cellular switchboard that regulates sensory and hormonal responses.
Rice Disease-Resistance Discovery Closes the Loop for Scientific Integrity
Researchers reveal how disease resistant rice detects and responds to bacterial infections.
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This month researchers at the Department of Biological Sciences at the University of Lethbridge published the latest in a series of papers describing characterization of breast cancer using microRNA expression profiling and epigenomic and proteomic measurements in rat model.

“Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications and Aberrant MicroRNA Expression” by Kovalchuk and co-workers

One most important outcome of the current study is the first time demonstration of miRNA expression in mammary tissue correlates with epigenetic dysregulation manifested in morphological changes and alteration of DNA methylation and histone methylation. In particular, using miRNA microarray analysis (provided by LC Sciences) of the E2-induced carcinogenesis development in rat, the down‑regulated miR‑22, miR‑99a, miR‑99b, and miR‑127 are shown to correlate with elevated target oncogene activities.  In this series of studies of the three main components of epigenetics, the authors concluded that “Changes in DNA and histone methylation, and, importantly, deregulation in the miRNAome may lead to the emergence of epigenetically reprogrammed cells with a tumor‑specific phenotype (inhibition of cell cycle arrest and apoptosis, activation of cell proliferation) leading to subsequent malignant transformation”.

LC Sciences pioneered miRNA microarray service and continues to be the leader in providing the most current miRNA probe content for miRNA expression profiling.  We currently offer the only comprehensive microRNA microarray service available with probe content of all species from Release 10.0 of the miRBase sequence database. The service package provided by LC Sciences has been developed and extensively used in thousands of successful experiments for addressing the questions in miRNA research.  Our results are proven to be of highest quality, reliable, relevant to related biological studies. In addition to standard public released miRNAs, LC Sciences offers fully customizable microarray products for detection and profiling of other types of regulatory RNAs, including ncRNAs and viral RNAs.



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