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Retractable Protein Nanoneedles
The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.
A Crystal Clear View of Biomolecules
Fundamental discovery triggers paradigm shift in crystallography.
Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
"Dark Side" of the Transcriptome
New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.
Advancing Synthetic Biology
Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.
Structure of Brain Plaques in Huntington's
Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder.
Visualizing a Cancer Drug Target at Atomic Resolution
Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.
Pumpjack" Mechanism for Splitting and Copying DNA
High-resolution structural details of cells' DNA-replicating proteins offer new insight into how these molecular machines function
The Power of Three
Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.
Biomarker for Recurring HPV-Linked Oropharyngeal Cancers
A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.
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microRNA Microarray Service
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LC Sciences

This month researchers at the Department of Biological Sciences at the University of Lethbridge published the latest in a series of papers describing characterization of breast cancer using microRNA expression profiling and epigenomic and proteomic measurements in rat model.

“Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications and Aberrant MicroRNA Expression” by Kovalchuk and co-workers

One most important outcome of the current study is the first time demonstration of miRNA expression in mammary tissue correlates with epigenetic dysregulation manifested in morphological changes and alteration of DNA methylation and histone methylation. In particular, using miRNA microarray analysis (provided by LC Sciences) of the E2-induced carcinogenesis development in rat, the down‑regulated miR‑22, miR‑99a, miR‑99b, and miR‑127 are shown to correlate with elevated target oncogene activities.  In this series of studies of the three main components of epigenetics, the authors concluded that “Changes in DNA and histone methylation, and, importantly, deregulation in the miRNAome may lead to the emergence of epigenetically reprogrammed cells with a tumor‑specific phenotype (inhibition of cell cycle arrest and apoptosis, activation of cell proliferation) leading to subsequent malignant transformation”.

LC Sciences pioneered miRNA microarray service and continues to be the leader in providing the most current miRNA probe content for miRNA expression profiling.  We currently offer the only comprehensive microRNA microarray service available with probe content of all species from Release 10.0 of the miRBase sequence database. The service package provided by LC Sciences has been developed and extensively used in thousands of successful experiments for addressing the questions in miRNA research.  Our results are proven to be of highest quality, reliable, relevant to related biological studies. In addition to standard public released miRNAs, LC Sciences offers fully customizable microarray products for detection and profiling of other types of regulatory RNAs, including ncRNAs and viral RNAs.



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