Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
Key to Natural Detoxifier’s Reactivity Discovered
Results have implications for health, drug design and chemical synthesis.
New Protein Found in Immune Cells
Immunobiologists from the University of Freiburg discover Kidins220/ARMS in B cells and demonstrate its functions.
Cell's Waste Disposal System Regulates Body Clock Proteins
New way to identify interacting proteins could identify potential drug targets.
How a Molecular Motor Untangles Protein
Diseases such as Alzheimer’s, Parkinson’s and prion diseases, all involve “tangled” proteins.
Compound Doubles Up On Cancer Detection
Researchers have found that tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer.
How Cell Growth Triggers Cell Division
Researchers in Jan Skotheim's lab have discovered a previously unknown mechanism that controls how large cells grow, an insight that could one day provide insight into attacking diseases such as cancer.
Probing the Forces Involved in Creating The Mitotic Spindle
Scientists at The Rockefeller University reveal new insights into the mechanical forces that govern elements of the mitotic spindle formation.
Identifying Cancer’s Food Sensors May Help to Halt Tumour Growth
Oxford University researchers have identified a protein used by tumours to help them detect food supplies. Initial studies show that targeting the protein could restrict cancerous cells’ ability to grow.
Specific Variations in RNA Splicing Linked to Breast Cancer
Researchers have identified cellular changes that may play a role in converting normal breast cells into tumors. Targeting these changes could potentially lead to therapies for some forms of breast cancer.
Thousands of Protein Interactions Identified
Thanks to the work by Utrecht University researcher Fan Liu and her colleagues, it is now possible to map the interactions between proteins in human cells.
Scroll Up
Scroll Down

Attamole Detection of Proteins in a Complex Mixture Using the SYNAPT G2-S System
Bookmark and Share

Waters Corporation

Protein identification is often challenged by the sensitivity and specificity required. For example, the presence of contaminating peptides within the collision cell during the collision-induced dissociation process leading to mixed fragment ion spectra is often ignored. This is overcome by the use of mobility assisted data independent acquisition (HDMSE) to qualitatively and quantitatively characterize enzymatic protein digests. This method has proven to be highly efficient when dealing with protein mixtures of varying complexity. Advancements in instrument technology allow HDMSE data acquisitions to be accompanied with increased sensitivity by incorporating StepWave™ ion optics. The StepWave device allows significantly more ions to be introduced while utilizing a robust mechanism for the elimination of neutral components and gas stream from the instrument, resulting in sub-femtomole sensitivity over a wide dynamic range. Here, we demonstrate the identification of known standard proteins spiked at varying levels into a complex sample matrix.

Further Information

Related Content

Waters’ Centers of Innovation Program Honors Ohio State University Laboratory
Wysocki-led facility recognized for proteomics, disease research and mass spectrometry excellence.
Wednesday, September 23, 2015
Waters Centers of Innovation Program Honors CSU Laboratory
Proteomics and metabolomics facility recognized for innovation in biological mass spectrometry.
Wednesday, October 29, 2014
Waters Q3 Revenues up 8 Percent
Company reports third quarter sales of $493 million, an increase of 8% versus sales of $457 million in the third quarter of 2013.
Tuesday, October 21, 2014
Waters Teams With Biochemical Society on Proteomics Training Day and Symposium
The consecutive events will take place on March 24 - 27, 2014 in Chester, England.
Wednesday, November 27, 2013
Waters Acquires Nonlinear Dynamics
Nonlinear Dynamics is best known for their Progenesis software which offers researchers unique ways to analyze and visualize the raw proteomic data.
Thursday, August 08, 2013
Waters Users’ Meeting at ASMS 2013
Register for the Waters Users’ meeting at ASMS 2013 and learn about the latest developments in Mass Spectrometry from Waters experts as we reveal our new technologies and solutions.
Monday, May 13, 2013
St. John’s Research Institute Honored by Waters Center of Innovation Program
Structural Proteomics Laboratory directed by Professor Dr Amit Kumar Mandal recognized for global disease research.
Thursday, April 11, 2013
Waters Updates Alliance HPLC Designs without Impacting Established Validated Methods
The updated system will maintain key Alliance performance specifications and control algorithms to ensure that analysts can seamlessly replicate their existing methods.
Tuesday, February 26, 2013
Biological Research Laboratory at Indiana University Receives Waters Center of Innovation Honors
Mass Spec research by Professor David Clemmer has paved the way for new discoveries in proteomics and protein characterization.
Thursday, December 13, 2012
Waters Corporation Releases 2012 Sustainability Report with GRI Certification
The report provides an in-depth review of the company’s sustainability efforts within the 2011 calendar year.
Thursday, October 25, 2012
Waters and Ireland's NIBRT Partner on Training and Research
The partnership will increase large molecule characterization capacity and knowledge, helping to deliver new, more effective therapeutic options.
Thursday, September 27, 2012
Waters and Nonlinear Dynamics to Co-Develop Next Generation Research Solutions
Firms to combine complimentary expertise in analytical science and informatics to advance proteomics and metabolomics research.
Friday, August 03, 2012
Thomson Mass Spectrometry Laboratory Selected as Waters Center of Innovation
Waters recognizes Prof. Marcos Eberlin for pioneering mass spectrometry.
Tuesday, January 31, 2012
Waters Welcomes Duke University Proteomics Core Facility into Centers of Innovation Program
Arthur Moseley, Ph.D. recognized for laboratory’s research and support of biomedical research at Duke University School of Medicine.
Monday, May 16, 2011
Waters Corporation and UCLA to Convene Leading Life Scientists
Will present latest research at applications of time of flight mass spectrometry conference September 13-15.
Monday, September 06, 2010
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos