Corporate Banner
Satellite Banner
Proteomics
Scientific Community
 
Become a Member | Sign in
Home>Resources>Application Notes>This Application Note
  Application Notes
Scientific News
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Structure of Essential Digestive Enzyme Uncovered
Using a powerful combination of techniques from biophysics to mathematics, researchers have revealed new insights into the mechanism of a liver enzyme that is critical for human health.
Getting a Better Look at How HIV Infects and Takes Over its Host Cells
A new approach, developed by a team of researchers led by The Rockefeller University and The Aaron Diamond AIDS Research Center (ADARC), offers an unprecedented view of how a virus infects and appropriates a host cell, step by step.
Untangling Disease-Related Protein Misfolding
Work advances understanding of genetic forms of thrombosis, emphysema, cirrhosis of the liver, neurodegenerative diseases and inflammation, among others.
Scientists Find Evidence That Cancer Can Arise Changes
Researchers at Rockefeller University have found a mutation that affects the proteins that package DNA without changing the DNA itself can cause a rare form of cancer.
US-India Collab Finds Molecular Signatures of Severe Malaria
Study may be a significant advancement in understanding the causes of severe malaria.
Triple-Negative Breast Cancer Target Is Found
Researchers at UC Berkeley discover a target that drives cancer metabolism in triple-negative breast cancer.
Crucial Reaction for Vision Revealed
Scientists have tracked the reaction of a protein responding to light, paving the way for a new understanding of life's essential reactions.
Cancer Can Arise from Histone Mutations
A mutation that affects the proteins that package DNA—without changing the DNA itself—can cause a rare form of cancer.
Scroll Up
Scroll Down

Visualisation and Comparison of SYNAPT G2-S LC/MS Data with Progenesis LC/MS
Bookmark and Share

Waters Corporation

In this technology brief, we present the precise large-scale, label-free analysis of high-density proteomic LC/MS data combined with a qualitative protein strategy that accurately identifies proteins and software that accurately quantifies proteins – both with high reproducibility. The depth to which a complex sample can be interrogated with minimal technical variation is crucial as this characterizes the lowest abundance limit of proteins that can be quantified. This is of equal importance for the software that analyzes LC/MS data since it ultimately defines protein and peptide false quantification rates. ProteinLynx GlobalSERVER™ and Progenesis LC/MS have been integrated, enabling highly accurate, label-free, relative protein quantification.


Large scale LC/MS-based discovery experiments that investigate increasingly complex proteomic samples are conducted to assess variation (either experimental or biological), profile samples, or to quantitatively gauge differences in protein abundance. These factors place a demand on the performance of the analytical LC/MS system, as well as on the bioinformatics software required to analyze the data. Robust peak detection, normalization, and alignment of multiple LC/ MS runs in larger scale studies are required as this will determine the lowest possible amount of proteins that can be resolved. Results from the SYNAPT® G2-S MS for differentially spiked protein standards in a complex cell lysate of Escherichia coli were used to demonstrate the application of Progenesis LC/MS.

To access this application note please click here for details.

Further Information

Related Content

It is All About the Product, Right?
Technology Networks met with Waters Corporation at its head office in Milford, MA to better understand the factors they use to drive business success.
Monday, January 11, 2016
Waters’ Centers of Innovation Program Honors Ohio State University Laboratory
Wysocki-led facility recognized for proteomics, disease research and mass spectrometry excellence.
Wednesday, September 23, 2015
Waters Centers of Innovation Program Honors CSU Laboratory
Proteomics and metabolomics facility recognized for innovation in biological mass spectrometry.
Wednesday, October 29, 2014
Waters Q3 Revenues up 8 Percent
Company reports third quarter sales of $493 million, an increase of 8% versus sales of $457 million in the third quarter of 2013.
Tuesday, October 21, 2014
Waters Teams With Biochemical Society on Proteomics Training Day and Symposium
The consecutive events will take place on March 24 - 27, 2014 in Chester, England.
Wednesday, November 27, 2013
Waters Acquires Nonlinear Dynamics
Nonlinear Dynamics is best known for their Progenesis software which offers researchers unique ways to analyze and visualize the raw proteomic data.
Thursday, August 08, 2013
Waters Users’ Meeting at ASMS 2013
Register for the Waters Users’ meeting at ASMS 2013 and learn about the latest developments in Mass Spectrometry from Waters experts as we reveal our new technologies and solutions.
Monday, May 13, 2013
St. John’s Research Institute Honored by Waters Center of Innovation Program
Structural Proteomics Laboratory directed by Professor Dr Amit Kumar Mandal recognized for global disease research.
Thursday, April 11, 2013
Waters Updates Alliance HPLC Designs without Impacting Established Validated Methods
The updated system will maintain key Alliance performance specifications and control algorithms to ensure that analysts can seamlessly replicate their existing methods.
Tuesday, February 26, 2013
Biological Research Laboratory at Indiana University Receives Waters Center of Innovation Honors
Mass Spec research by Professor David Clemmer has paved the way for new discoveries in proteomics and protein characterization.
Thursday, December 13, 2012
Waters Corporation Releases 2012 Sustainability Report with GRI Certification
The report provides an in-depth review of the company’s sustainability efforts within the 2011 calendar year.
Thursday, October 25, 2012
Waters and Ireland's NIBRT Partner on Training and Research
The partnership will increase large molecule characterization capacity and knowledge, helping to deliver new, more effective therapeutic options.
Thursday, September 27, 2012
Waters and Nonlinear Dynamics to Co-Develop Next Generation Research Solutions
Firms to combine complimentary expertise in analytical science and informatics to advance proteomics and metabolomics research.
Friday, August 03, 2012
Thomson Mass Spectrometry Laboratory Selected as Waters Center of Innovation
Waters recognizes Prof. Marcos Eberlin for pioneering mass spectrometry.
Tuesday, January 31, 2012
Waters Welcomes Duke University Proteomics Core Facility into Centers of Innovation Program
Arthur Moseley, Ph.D. recognized for laboratory’s research and support of biomedical research at Duke University School of Medicine.
Monday, May 16, 2011
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!