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Protein-Based “Cancer Signature” Uncovered
Researchers investigated the expression of ribosomal proteins in human tissues and discovered a cancer type specific signature which could be used to predict the progression of the disease.
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‘NoBody,’ a Microprotein On a Mission
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Largest Resource of Protein-Protein Interactions
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Bright Red Fluorescent Protein Created
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Protein Self-Regulates Abundance
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'Lab on the Skin' for Sweat Analysis
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Building Better Nanodiscs
Researchers have improved upon the design of nanodiscs that provide an unprecedented view of viral infection.
Breast Cancer Cells Starve for Cystine
Depriving triple negative breast cancer, a treatment-resistant form of breast cancer, of cystine results in cancer cell death.
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Novel ProteoPrep® 20 Immunoaffinity Depletion Resin for Human Plasma
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Sigma Aldrich

The study of the human plasma proteome is an area of hugeimportance, especially for the pharmaceutical potential ofidentifying disease biomarkers. Many proteins of interestappear at low concentrations in the plasma and are, therefore,difficult to detect.

Identification of potential biomarkers is especially difficult dueto the presence of higher abundance proteins. To addressthese issues, an affinity resin has been developed for removalof 20 high abundance proteins from 8 µl of plasma. Depletionof these abundant proteins allows for visualization of proteinsthat co-migrate with, and are masked by, the high abundanceproteins during 1-D or 2-D gel electrophoresis andHPLC separations. Plasma proteins can then be loaded ontogels, IPG strips, or HPLC columns at higher levels for improvedvisualization/detection of low copy number proteins.

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