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Chemical Biology Approaches to Target Protein Modification in Disease
Imperial College London

My group works in the emerging multidisciplinary field of chemical proteomics, where we design and apply chemistry-driven approaches to explore posttranslational modification (PTM) in living systems. A constant theme in our work is the validation of enzymes involved in PTM as drug targets and discovery of novel drug-like enzyme inhibitors, using tools ranging from protein total synthesis and labelling to activity-based protein profiling and proteomics. Recent technological advances based on bioorthogonal ligation chemistry have enabled several classes of PTM, including protein lipidation, to be probed with greatly enhanced speed and flexibility, and are rapidly supplanting older approaches such as radiolabelling. In this presentation I will highlight some of our recent advances in probing protein lipidation using chemical proteomics, and describe how we have applied this technology to understand and exploit novel drug targets in protein lipidation pathways in parasitic infection and cancer.

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