Retractable Protein Nanoneedles The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.A Crystal Clear View of Biomolecules Fundamental discovery triggers paradigm shift in crystallography.Charting Kidney Cancer Metabolism Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy."Dark Side" of the Transcriptome New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.Advancing Synthetic Biology Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.Structure of Brain Plaques in Huntington's Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder. Visualizing a Cancer Drug Target at Atomic Resolution Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.Pumpjack" Mechanism for Splitting and Copying DNA High-resolution structural details of cells' DNA-replicating proteins offer new insight into how these molecular machines functionThe Power of Three Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.Biomarker for Recurring HPV-Linked Oropharyngeal Cancers A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.
A New Proteomics Workflow for the Identification of PTMs (Post Translational Modifications) Quantitative proteomics is an essential tool in molecular biology and biomedical sciences. SILAC is a commonly used workflow in which proteins are labelled with stable isotopes, digested into peptides and separated by chromatography for detection in a mass spectrometer.
Translation of Omic Data into Personalised Oncology Tools The Challenge and the Reward William Gallagher, University College Dublin, speaking at Diagnostics & Biomarkers 2015.
Plasma Vitronectin Predicts Response to Fluoropyrimidine-oxaliplatin (FOLFOX) Chemotherapy in Metastatic Colorectal Cancer Sarah Hayes, University of Sydney, speaking at Diagnostics & Biomarkers 2015.
Microwave-to-Terahertz Sensing in Microfluidic Systems Norbert Klein, Imperial College London, speaking at Lab-on-a-Chip & Microfluidics 2015
Parallel Tracking i-biomarkerT Development with Drug Development for Maximum Benefit Kevin Cox, Imanova Limited, speaking at Diagnostics & Biomarkers.
Development of a Point-of-Care Diagnostic for Influenza Detection with Antiviral Treatment Effectiveness Indication Richard Murdock, USAF, speaking at Point of Care Diagnostics 2015
Drug Sensitivity and Resistance Testing Platform for Personalized Medicine at the Institute for Molecular Medicine Finland (FIMM) Jani Saarela, Institute for Molecular Medicine, speaking at Screening Europe 2015
Oncology Biomarker Testing Current US Practice Baseline and Emerging Trends Julia Trosman, Center for Business Models in Healthcare, speaking at Diagnostics & Biomarkers 2015.
Interfering Peptides Targeting Protein-Protein Interactions Katja Arndt, University of Potsdam, speaking at Discovery Chemistry Congress 2015.
Highly-integrated Lab-on-a-chip System for Multiparameter Analysis at the Point-of-care Harald Peter, Fraunhofer Institute for Cell Therapy and Immunology IZI-BB