Retractable Protein Nanoneedles The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.A Crystal Clear View of Biomolecules Fundamental discovery triggers paradigm shift in crystallography.Charting Kidney Cancer Metabolism Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy."Dark Side" of the Transcriptome New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.Advancing Synthetic Biology Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.Structure of Brain Plaques in Huntington's Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder. Visualizing a Cancer Drug Target at Atomic Resolution Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.Pumpjack" Mechanism for Splitting and Copying DNA High-resolution structural details of cells' DNA-replicating proteins offer new insight into how these molecular machines functionThe Power of Three Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.Biomarker for Recurring HPV-Linked Oropharyngeal Cancers A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.
The Potassium Channels Kv1.3 and KCa3.1 as Targets for Inflammatory Brain Pathologies Professor Heike Wulff, University of California, speaking at Ion Channel Targets 2011.
Alpha2* Nicotinic Acetylcholine Receptors as a Therapeutic Target for Memory Enhancement Dr Katumi Sumikawa, University of California, speaking at Ion Channel Targets 2011.
Smooth Muscle Kv7 (KCNQ) Potassium Channels: Important New Therapeutic Targets Professor Kenneth Byron, Loyola University Chigaco, speaking at Ion Channel Targets 2011.
A Systematic Investigation of Candidate Breast Cancer Progression-Associated Biomarkers Identified from Omic Screens: Leveraging Antibody-Based Proteomics Prof. William Gallagher, Chief Scientific Officer at OncoMark, speaking at Advances in Microarray Technology 2011.
3D-Gel Electrophoresis, a New Development in Protein Analysis Robert Ventzki, University of Greifswald, speaking at Advances in Separation Technology 2011.
Quantitative Proteomics For Biomarker Discovery and Validation: Prostate Cancer Case Study Stephen Pennington, UCD Dublin, Professor of Proteomics, speaking at European Biomarkers Summit 2011.
Genome-scale Quantitative Tumour Proteomics for Cancer Biomarkers Discovery Metodi Metodiev, Lecturer/Director of Proteomics Unit, University of Essex, speaking at European Biomarkers Summit 2011.
Mode of Action Analysis and Biomarker Discovery Using Mass Spectrometry-Based Phosphoproteomics Technologies Andreas Jenne, CEO, Kinaxo, speaking at European Biomarkers Summit 2011.
Development of a Blood Based Molecular Test to Aid in the Diagnosis of Schizophrenia Emanuel Schwarz, Post Doctoral Researcher, University of Cambridge, speaking at European Biomarkers Summit 2011.