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Charting Kidney Cancer Metabolism
Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy.
"Dark Side" of the Transcriptome
New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.
Advancing Synthetic Biology
Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.
Structure of Brain Plaques in Huntington's
Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder.
Visualizing a Cancer Drug Target at Atomic Resolution
Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.
Pumpjack" Mechanism for Splitting and Copying DNA
High-resolution structural details of cells' DNA-replicating proteins offer new insight into how these molecular machines function
The Power of Three
Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.
Biomarker for Recurring HPV-Linked Oropharyngeal Cancers
A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University.
Light Signals from Living Cells
Fluorescent protein markers delivered under high pressure.
Cellular 'Relief Valve'
A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
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Bicyclic Peptides with Antibody-Like Binding Affinity and Specificity
Dr Vanessa Baeriswyl, EPFL, speaking at Stem Cells & Bioprocessing Europe 2012.

Typical Phospho-form Abundance Profile of Cellular ERK Discovered by Quantitative UPLC-MS
Wolf Lehmann, German Cancer Research Center, speaking at Systems Biology Europe 2012

Proteomic and Bioinformatic Approaches to the Development of Biomarker Signatures of Clinical Utility for Prostate Cancer: From Discovery to Targeted Verification
Stephen Pennington, University College Dublin, speaking at Systems Biology Europe 2012

Secretome Proteomics for Tumor Biomarker Discovery
Josep Villanueva, Vall d'Hebron Institute of Oncology (VHIO), speaking at Systems Biology Europe 2012

In vivo SILAC-based Proteomics Reveals Phosphoproteome Changes during Skin Carcinogenesis
Sara Zanivan, Beatson Institute for Cancer Research, speaking at Systems Biology Europe 2012

Results From Serum-Tumorautoantibody Profiling of Breast, Colon, Lung and Prostate Cancers Using a 16k Protein Array for Improving Minimal Invasive Diagnostics
Andreas Weinhäusel, Austrian Institute of Technology GmbH, speaking at Systems Biology Europe 2012

Proteomic Identification of Putative Biomarkers of Radiotherapy Resistance
Lynn Cawkwell, University of Hull, speaking at Systems Biology Europe 2012

Recent Progress in Core-shell and Embedded Nanoparticle Technology for Biomarker Separation with Amperometric Sensing at a Boron Doped Diamond Electrode
Jeremy Glennon, University College Cork, speaking at European Lab Automation 2012

Kinase Centric Chemical Proteomics Provides Novel Insights into Individual Cancer Biology
Bernhard Kuster, Technical University Munich, speaking at Systems Biology Europe 2012

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