Charting Kidney Cancer Metabolism Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy."Dark Side" of the Transcriptome New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.Advancing Synthetic Biology Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.Structure of Brain Plaques in Huntington's Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder. Visualizing a Cancer Drug Target at Atomic Resolution Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.Pumpjack" Mechanism for Splitting and Copying DNA High-resolution structural details of cells' DNA-replicating proteins offer new insight into how these molecular machines functionThe Power of Three Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.Biomarker for Recurring HPV-Linked Oropharyngeal Cancers A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University. Light Signals from Living Cells Fluorescent protein markers delivered under high pressure.Cellular 'Relief Valve' A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
Bicyclic Peptides with Antibody-Like Binding Affinity and Specificity Dr Vanessa Baeriswyl, EPFL, speaking at Stem Cells & Bioprocessing Europe 2012.
Typical Phospho-form Abundance Profile of Cellular ERK Discovered by Quantitative UPLC-MS Wolf Lehmann, German Cancer Research Center, speaking at Systems Biology Europe 2012
Proteomic and Bioinformatic Approaches to the Development of Biomarker Signatures of Clinical Utility for Prostate Cancer: From Discovery to Targeted Verification Stephen Pennington, University College Dublin, speaking at Systems Biology Europe 2012
Secretome Proteomics for Tumor Biomarker Discovery Josep Villanueva, Vall d'Hebron Institute of Oncology (VHIO), speaking at Systems Biology Europe 2012
In vivo SILAC-based Proteomics Reveals Phosphoproteome Changes during Skin Carcinogenesis Sara Zanivan, Beatson Institute for Cancer Research, speaking at Systems Biology Europe 2012
Results From Serum-Tumorautoantibody Profiling of Breast, Colon, Lung and Prostate Cancers Using a 16k Protein Array for Improving Minimal Invasive Diagnostics Andreas Weinhäusel, Austrian Institute of Technology GmbH, speaking at Systems Biology Europe 2012
Proteomic Identification of Putative Biomarkers of Radiotherapy Resistance Lynn Cawkwell, University of Hull, speaking at Systems Biology Europe 2012
Recent Progress in Core-shell and Embedded Nanoparticle Technology for Biomarker Separation with Amperometric Sensing at a Boron Doped Diamond Electrode Jeremy Glennon, University College Cork, speaking at European Lab Automation 2012
Kinase Centric Chemical Proteomics Provides Novel Insights into Individual Cancer Biology Bernhard Kuster, Technical University Munich, speaking at Systems Biology Europe 2012