Charting Kidney Cancer Metabolism Changes in cell metabolism are increasingly recognized as an important way tumors develop and progress, yet these changes are hard to measure and interpret. A new tool designed by MSK scientists allows users to identify metabolic changes in kidney cancer tumors that may one day be targets for therapy."Dark Side" of the Transcriptome New approach to quantifying gene "read-outs" reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases.Advancing Synthetic Biology Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.Structure of Brain Plaques in Huntington's Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder. Visualizing a Cancer Drug Target at Atomic Resolution Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.Pumpjack" Mechanism for Splitting and Copying DNA High-resolution structural details of cells' DNA-replicating proteins offer new insight into how these molecular machines functionThe Power of Three Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.Biomarker for Recurring HPV-Linked Oropharyngeal Cancers A look-back analysis of HPV infection antibodies in patients treated for oropharyngeal (mouth and throat) cancers linked to HPV infection suggests at least one of the antibodies could be useful in identifying those at risk for a recurrence of the cancer, say scientists at the Johns Hopkins University. Light Signals from Living Cells Fluorescent protein markers delivered under high pressure.Cellular 'Relief Valve' A team led by scientists at The Scripps Research Institute (TSRI) has solved a long-standing mystery in cell biology by showing essentially how a key “relief-valve” in cells does its job.
Too Big for a Small World? Intact Protein Analysis by Nano-UHPLC-MS/MS Mark Parkin, Kings College London, speaking at European Lab Automation 2012
Capacitive Immunosensors – A Tool for Detection Where Sensitivity of Conventional ELISA is Not Sufficient Prof. Bo Mattiasson, Lund University, speaking at Advances in Biodetection and Biosensors 2012.
Circulating Tumor Cells: Current State and Future Perspectives Prof Klaus Pantel, University Medical Center Hamburg-Eppendorf, speaking at Molecular Diagnostics Europe 2012.
Continuous Chromatography (MCSGP) for the Purification of Therapeutic Proteins Dr Thomas Müller-Späth, ETH Switzerland, speaking at BioProcessing, Biologics & Biotherapeutics Congress 2011.
Homology-Driven Proteomics by LC-MS/MS Dr. Andrej Shevchenko, Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), speaking at Mass Spec Europe 2011.
Multiplexed Homogenous Proximity Extension Assays for High-throughput Protein Biomarker Research Dr Martin Lundberg, Olink Bioscience, speaking at Molecular Diagnostics Asia 2011.
Improving Protein Identifications by Utilization of Amino Acid Composition Information Extracted from High-mass Accuracy ETD and HCD Spectra Professor Frank Kjeldsen, University of Southern Denmark, speaking at Mass Spec Europe 2011.
Peptide Fragmentation in a Proteomics Workflow Assistant Professor Maarten Altelaar, Utrecht University, speaking at Mass Spec Europe 2011.
Actionable Biomarkers for Rheumatoid Arthritis Dr William Robinson, Stanford University, speaking at Microarray World Congress 2011.