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Wednesday, January 28, 2015
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Featured Products
Featured Product - CyFlow® Cube 8
CyFlow® Cube 8
Featured Product - microRNA Purification Kit
microRNA Purification Kit

Webcasts
Webcast - Accelerate Your Research With Tecan´s New Multimode Microplate Reader Platform!Accelerate Your Research With Tecan´s New Multimode Microplate Reader Platform!
In this webinar, solutions will be presented for fast DNA quantification, single cell counting and viability analysis, and automating long-term live kinetic cell assays.
Webcast - Bacterial Genomic Changes Revealed through Next-generation Sequencing Data AnalysisBacterial Genomic Changes Revealed through Next-generation Sequencing Data Analysis
Lori Snyder, Kingston University, speaking at NSG & Big Data 2014

Market Reports
RNAi
RI Technologies

The report serves as a guide to global RNAi industry covering 280 plus companies that are engaged in RNAi synthesis, R&D, therapeutics, test kits, tools and services.
Innovation in the Prefilled Syringe Market - Biologics and Autoinjection Devices Shaping Future R&D Trends
Global Data

The report provides insights into possible future avenues of R&D in the prefilled syringe market. This includes an overview of problems and possible solutions, as well as discussion of how the devices have developed to date to address problems with contamination, safety, fragility and ease of use.
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018
GBI Research

The currently marketed monoclonal antibodies are highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. Significant market exclusivity, expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.
qPCR Assay Trends 2013
HTStec

HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
siRNA Screening Trends
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on siRNA screening carried out in September 2012.
MicroRNAs and Exosomes
Select Biosciences Ltd

In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
MicroRNA Market Trends 2011
Select Biosciences Ltd

In this report, we focus upon the microRNA marketplace via primary market research that allows us to identify qualitative and quantitative trends from the bottom-up.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd

In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Circulating Tumor Cells (CTCs) Market Trends 2011
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the circulating tumor cells (CTCs) space. In this report, we focus upon the emerging marketplace for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastasis and mechanisms thereof.
Scientific News
Cancer-Causing Virus Blocks Human Immune Response
Epstein-Barr virus shown to outwit the human immune response using microRNAs.
Major Study Links Gene to Drug Resistance in Testicular Cancer
Researchers used a genetic technique called whole-exome sequencing to examine tumour samples.
New Blood Test For Aggressive Bone Cancer
Researchers at the University of East Anglia are developing a simple blood test to diagnose bone cancer thanks to funding from the Big C.
NIH Researchers Tackle Thorny Side of Gene Therapy
Pre-clinical studies in mice reveal ways to reduce cancer risk with modified treatment.
Tumor Suppressor Protein Plays Key Role In Maintaining Immune Balance
St. Jude Children’s Research Hospital scientists show that the PTEN tumor suppressor protein is essential for proper regulatory T cell function; discovery offers new focus for improving treatment of autoimmune diseases.
GRP78 Protein Possible Universal Therapeutic Target
Drug combination including Viagra is effective tool in targeting the protein.
Bad Luck of Random Mutations Plays Predominant Role in Cancer, Study Shows
Statistical modeling links cancer risk with number of stem cell divisions.
3-D Culture System for Pancreatic Cancer has Potential to Change Therapeutic Approaches
Organoid technology with human tissue provides a model for full progression of the disease.
Targeting The Cell’s ‘Biological Clock’
Researchers target the cell’s ‘biological clock’ in promising new therapy to kill cancer cells, shrink tumor growth.
Whole-Genome Sequencing Successfully Identifies Cancer-Related Mutations
UT Southwestern Medical Center cancer researchers have demonstrated that whole-genome sequencing can be used to identify patients’ risk for hereditary cancer.
Business News
Featured Article
Wyss Institute Videos Now on LabTube
The Wyss Institute for Biologically Inspired Engineering has created a channel on Labtube.

GenomeDx Biosciences Implements Clarity LIMS for use in Clinical Lab
LIMS to support Decipher® Test for personalizing treatment for prostate cancer patients.
Aprea Granted European Orphan Drug Designation for APR-246 in Ovarian Cancer
Company is currently conducting a Phase Ib/II trial of APR-246.
New Oncology and University Hospital Oslo Announce Genomic Profiling Collaboration
Collaboration to identify alterations in cancer-related tumour genes.
Trovagene, Genomac Expand Colorectal Cancer Collaboration
Prospective clinical studies to evaluate Trovagene's Precision Cancer Monitoring platform to determine the emergence of resistance mutations using circulating tumor DNA.
Abcam Acquires Firefly BioWorks
Acquisition will expand Abcam’s capabilities in multiplex analysis.
Prof. Dr. Helga Rübsamen-Schaeff and Joerg von Petrikowsky Join 4SC AG
Prof. Dr. Rübsamen-Schaeff and Mr. von Petrikowsky will replace the Supervisory Board members Dr. Thomas Werner and Klaus Kühn.
Lilly, Merck Enter Collaboration Agreement
Agreement to research immuno-oncology combination regimens in multiple types of cancer.
Dako, Cell Signalling Tech Partner with Companion Diagnostics
Partnership for development of high-quality, cutting-edge companion diagnostic products for diagnosis and treatment of cancer.
Compugen Discloses Initial Experimental Results for Predicted ADC Targets
Pipeline program for oncology to be further expanded and diversified with addition of ADC therapeutic programs to ongoing immuno-oncology programs.

Events
Sony DADC, SCIENION & Invetech
28 Jan 2015
Sony DADC, SCIENION & Invetech ...
More information
Webinar: Accelerate Your Resea
10 Feb 2015
Webinar: Accelerate Your Resea ...
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RNA Therapeutics
16 Feb 2015
RNA Therapeutics ...
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8th Oncology Biomarker
18 Mar 2015
8th Oncology Biomarker ...
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ePosters
Population characterization of Brazilian isolates of Ceratocystis spp. using microsatellites
1Faculdade de ciências agronômicas, UNESP Botucatu, SP. Brazil   2Forestry and Agricultural Biotechnology Institute (FABI), Private Bag X20, University of Pretoria, Pretoria, 0028, South Africa

The genus Ceratocystis includes several species of economically important plant pathogens and has a global distribution. In Brazil, species in the genus cause disease and death of hosts such as cacao, eucalypts and mango. This study aimed to characterize the population structure and diversity of isolates of Ceratocystis fimbriata sensu lato collected from diseased Eucalyptus species and to compare these to isolates from cacao, mango, teak, fig, rubber and atemoya.
Geneious R8: A Powerful and Comprehensive Suite of Molecular Biology Tools

Biomatters, Inc & Biomatters, Ltd.

Geneious R8: A powerful and comprehensive suite of molecular biology tools.
Putative Genes Identified on Two Growth Conditions of G. boninense


Putative genes identified on two growth conditions of Ganoderma boninense.
TFAP2B is Associated with WNT/ß-catenin Pathway in Luminal Breast Cancer
1. Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Germany 2. Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Germany 3. Department of Clinica

Here we aimed to investigate which molecular mechanisms are associated with TFAP2B expression in luminal breast cancer.
Transcription Factors to Classify Tumor Types and Subtypes
1. Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Germany 2. Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Germany 3. Department of Clinica

Here we introduce the use of the unsupervised approach to identify transcription factors (TFs) that are specific for different tumor types.
Expression Profiling of Circulating Tumor Cells: a Prognostic and Predictive Biomarker in Cancer.
Bauer4.1TATAA Biocenter, Göteborg, Sweden (www.tataa.com); 2Inst. of Biotechnology, CAS, Czech Republic; 3AdnaGen GmbH, Ostpassage7, D-30853 Langenhagen, Germany (www.adnagen.com); 4Dep of Gynecoland

We show non-responders to treatment among breast cancer patients can be identified by expression profiling of circulating tumor cells
Experimental Evolution in Diatoms - Thermal longterm acclimation in two model diatom species
1 University of East Anglia, School of Environmental Science, Norwich, UK 2Institute of Evolutionary Biology, University of Edinburgh, Kings Building, Ashworth Laboratories, West

Experimental Evolution in two model Diatoms
Efficacy of Gene Therapy in Restoring Vision in Leber's Congenital Amaurosis
Open University

The research reviews current knowledge of the genetic causes of Leber's congenital amaurosis (LCA) and the development of a gene therapy intervention for LCA. The efficacy as well as the limitations of this form of treatment are evaluated in detail and recommendations are made for the future directions of gene therapy for Leber's congenital amaurosis.

Flow Enhancement and Dynamic of Microfluidic Base Biosensor
University Malaysia Pahang

The design of new biosesnor base on microfluidic system is presented. The design is consist of two chips, Microchannels chip and electrodes chip. By varying the size and optimizing the microchannels and electrode, the sensitivity of the biosensor will increase.
Recent Technical Developments in the Standardized Separation and Measurement of Extracellular Vesicles
(1) Izon Science US Ltd, Christchurch, New Zealand (2) The University of Queensland, Brisbane, QLD, Australia

We present robust and practical solutions for the standardization of EV isolation and concentration measurement. EV concentration also needs to have a defined size range. With these solutions, significant improvement in the reproducibility and comparability of results between different researchers is possible.
Application Notes
Assessing Drug Encapsulation Efficiency using Nanoparticle Tracking Analysis
Malvern Instruments Limited

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Automated Illumina NGS Sample Preparation: TruSeq® Stranded mRNA on the Hamilton Microlab STAR
Hamilton Robotics

Illumina’s sample preparation kits produce high quality libraries for DNA and RNA sequencing. Hamilton offers the robust Microlab STAR line of robotic liquid handling workstations for automating sample preparation. Together, the automation of the TruSeq Stranded mRNA sample preparation protocol on the STAR gives the user hours of reliable, unattended library preparation.
Automating Aqueous Compound Solubility Using the 96-Well Multiscreen® Solubility Filter Plate on a Hamilton Microlab® Star Workstation
Hamilton

Here we describe an automated method for determining drug solubility using Millipore’s MultiScreen Solubility filter plate on the Hamilton MICROLAB STAR workstation.
A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
BMG LABTECH

Post-translational histone modifications like acetylation play a pivotal role in the epigenetic regulation of transcription. Catalyzing the latter reaction HDACs affect various cellular processes especially cancerogenesis. Although the mechanism of starting cancerogenesis by epigenetic events is not clearly explained inhibition of HDACs has highlighted as a viable principle in cancer therapy.
Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.
Sequence-Specific DNA Assay
Molecular Devices

The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
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