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 | Non-Coding RNA and Chromatin Remodeling: Epigenetic Control of Transcription Ingrid Grummt, German Cancer Research Center, speaking at Genomics Research Europe 2012 |
 | Guiding Treatment Decisions in Cancer using Protein Biomarker Measurements: from Design to Utility Prof. Stephen Pennington, University College Dublin, speaking at Discovery Chemistry Congress 2013. |
qPCR Assay Trends 2013
HTStec
HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
CTC Technologies
RI Technologies
This report on Circulating Tumor Cells (CTC) Technologies gives a market insight into technologies and services used for cancer detection.
siRNA Screening Trends
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on siRNA screening carried out in September 2012.
MicroRNAs and Exosomes
Select Biosciences Ltd
In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
RNAi
RI Technologies
This report covers both products and services in the RNAi industry. The global RNAi market is analyzed by Tools/Products and Applications for each of the geographic regions- United States, Europe, Asia-Pacific and Rest of World.
RNA Therapeutics Pipeline Database
La Merie
Subscription to La Merie’s proprietary RNA Therapeutics Pipeline Database provides online access to RNA Therapeutics on the market and in research & development.
Personalized Medicine for Cancer
GlobalData
The report is an essential source of information on the Personalized Medicine for Cancer . The report also provides insights on the companion diagnostics and marketed personalized drugs for cancer.
MicroRNA Market Trends 2011
Select Biosciences Ltd
In this report, we focus upon the microRNA marketplace via primary market research that allows us to identify qualitative and quantitative trends from the bottom-up.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd
In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
HTStec
HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
CTC Technologies
RI Technologies
This report on Circulating Tumor Cells (CTC) Technologies gives a market insight into technologies and services used for cancer detection.
siRNA Screening Trends
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on siRNA screening carried out in September 2012.
MicroRNAs and Exosomes
Select Biosciences Ltd
In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
RNAi
RI Technologies
This report covers both products and services in the RNAi industry. The global RNAi market is analyzed by Tools/Products and Applications for each of the geographic regions- United States, Europe, Asia-Pacific and Rest of World.
RNA Therapeutics Pipeline Database
La Merie
Subscription to La Merie’s proprietary RNA Therapeutics Pipeline Database provides online access to RNA Therapeutics on the market and in research & development.
Personalized Medicine for Cancer
GlobalData
The report is an essential source of information on the Personalized Medicine for Cancer . The report also provides insights on the companion diagnostics and marketed personalized drugs for cancer.
MicroRNA Market Trends 2011
Select Biosciences Ltd
In this report, we focus upon the microRNA marketplace via primary market research that allows us to identify qualitative and quantitative trends from the bottom-up.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd
In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Single-Cell Transfection Tool Enables Added Control for Biological Studies
Northwestern University researchers have developed a new method for delivering molecules into single, targeted cells through temporary holes in the cell surface.
ATARiS Informatics Platform Hits the Jackpot
ATARiS is one of several tools developed at the Broad Institute to precisely tune in to the signals within noisy datasets.
miRNA Regulated Networks Identified in Cystic Fibrosis
The IDT newsletter DECODED features the latest research to rescue the CFTR functionality.
Finding, Fighting the Fat that Fuels Cancer
UT Southwestern research examines role of certain fat cells in tumorigenesis.
Yale Cancer Center Carves New Path in Immunotherapy
Cancer immunotherapy is showing promise in treating patients with a variety of advanced, metastatic tumors.
Preclinical Tests Shows Agent Stops “Slippery” Proteins from Binding, Causing Ewing Sarcoma
Some tumors regressed to the point that cancer cells could not be detected microscopically.
Researchers Unearth New Clues About How Prostate Cancer Evolved
With the help of a computational model, Broad researchers were able to reconstruct the genomes of prostate cancer cells.
Researchers Identify Four New Genetic Risk Factors for Testicular Cancer
Large, first-of-its-kind study finds genomic regions associated with higher risk.
CU Study Suggests Link Between Tumor Suppressors and Starvation Survival
A particular tumor suppressor gene that fights cancer cells does more than clamp down on unabated cell division, it also can help make cells more fit by allowing them to fend off stress.
Studies Generate ‘Comprehensive’ List of Genes Required to Defend Sex Cells from Transposons
The piRNA pathway protects eggs and sperm from ‘jumping genes’ that can cause developmental defects, sterility.
Northwestern University researchers have developed a new method for delivering molecules into single, targeted cells through temporary holes in the cell surface.
ATARiS Informatics Platform Hits the Jackpot
ATARiS is one of several tools developed at the Broad Institute to precisely tune in to the signals within noisy datasets.
miRNA Regulated Networks Identified in Cystic Fibrosis
The IDT newsletter DECODED features the latest research to rescue the CFTR functionality.
Finding, Fighting the Fat that Fuels Cancer
UT Southwestern research examines role of certain fat cells in tumorigenesis.
Yale Cancer Center Carves New Path in Immunotherapy
Cancer immunotherapy is showing promise in treating patients with a variety of advanced, metastatic tumors.
Preclinical Tests Shows Agent Stops “Slippery” Proteins from Binding, Causing Ewing Sarcoma
Some tumors regressed to the point that cancer cells could not be detected microscopically.
Researchers Unearth New Clues About How Prostate Cancer Evolved
With the help of a computational model, Broad researchers were able to reconstruct the genomes of prostate cancer cells.
Researchers Identify Four New Genetic Risk Factors for Testicular Cancer
Large, first-of-its-kind study finds genomic regions associated with higher risk.
CU Study Suggests Link Between Tumor Suppressors and Starvation Survival
A particular tumor suppressor gene that fights cancer cells does more than clamp down on unabated cell division, it also can help make cells more fit by allowing them to fend off stress.
Studies Generate ‘Comprehensive’ List of Genes Required to Defend Sex Cells from Transposons
The piRNA pathway protects eggs and sperm from ‘jumping genes’ that can cause developmental defects, sterility.
RaySearch and IBA to Increase Proton Therapy Precision
Collaboration agreement signed on the development of proton treatment planning system.
RBCC Opens Talks to Acquire Tech Innovators in $142 Billion Drug Delivery Market
Talks come as part of the company’s push to carve out a share of the $142 billion U.S. drug delivery market.
Successful Validation and Approval of the PapilloCheck HPV Test
The PapilloCheck HPV test from Greiner Bio-One GmbH has now received approval from the Dutch Society for Pathology.
G-BA Issues Final Assessment Report for PIXUVRI®
Pricing negotiations to begin in June.
Novozymes Biopharma Helps Innovative Dry Eye Therapy Move into Clinical Trials
A novel ophthalmic solution has recently obtained FDA approval to undergo Phase I/II clinical trials in the United States.
Elan Announces Transactions: Decisively Transforming the Company
Upon shareholder approval, the totality of these strategically driven decisions will form a dynamic and unique business foundation for Elan in the years ahead.
Nuvilex, Inc. and Celgene, Corp. Can Both Replace Eli Lilly's Cancer Drug Gemzar
The race is on, and patients with advanced stage, inoperable pancreatic cancer will be the recipients of the winner's treatment.
GE Scientists in Technology “Relay Race” Against Cancer
GE technologies being developed to impact every stage of cancer patient care from screening to treatment and monitoring.
Aeolus Strengthens Board of Directors
Aeolus Pharmaceuticals, Inc. announced the appointment of John M. Clerici, Mitchell D. Kaye, and Jeffrey A. Scott, M.D., to its board of directors.
Curie-Cancer and Roche Strengthen Partnership
Curie-Cancer and Roche build on four years partnership by increasing translational research programs, speeding up development of new cancer treatments.
Collaboration agreement signed on the development of proton treatment planning system.
RBCC Opens Talks to Acquire Tech Innovators in $142 Billion Drug Delivery Market
Talks come as part of the company’s push to carve out a share of the $142 billion U.S. drug delivery market.
Successful Validation and Approval of the PapilloCheck HPV Test
The PapilloCheck HPV test from Greiner Bio-One GmbH has now received approval from the Dutch Society for Pathology.
G-BA Issues Final Assessment Report for PIXUVRI®
Pricing negotiations to begin in June.
Novozymes Biopharma Helps Innovative Dry Eye Therapy Move into Clinical Trials
A novel ophthalmic solution has recently obtained FDA approval to undergo Phase I/II clinical trials in the United States.
Elan Announces Transactions: Decisively Transforming the Company
Upon shareholder approval, the totality of these strategically driven decisions will form a dynamic and unique business foundation for Elan in the years ahead.
Nuvilex, Inc. and Celgene, Corp. Can Both Replace Eli Lilly's Cancer Drug Gemzar
The race is on, and patients with advanced stage, inoperable pancreatic cancer will be the recipients of the winner's treatment.
GE Scientists in Technology “Relay Race” Against Cancer
GE technologies being developed to impact every stage of cancer patient care from screening to treatment and monitoring.
Aeolus Strengthens Board of Directors
Aeolus Pharmaceuticals, Inc. announced the appointment of John M. Clerici, Mitchell D. Kaye, and Jeffrey A. Scott, M.D., to its board of directors.
Curie-Cancer and Roche Strengthen Partnership
Curie-Cancer and Roche build on four years partnership by increasing translational research programs, speeding up development of new cancer treatments.
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The Challenges of Relieving Cancer Pain: A Literature Review
NHS
This study aims to explore the discrepancy between the increasing array of treatments for cancer pain, as well as the evidence that it can be managed effectively in the majority of cases, and its persisting prevalence.
Evaluation of 2012 Bowel Cancer Awareness and Early Diagnosis Campaign at a District General Hospital
Brighton and Sussex University Hospitals
Following the regional Be Clear on Cancer campaign, the Department of Health launched a national bowel cancer awareness campaign from 30 January 2012. The campaign ran until the end of March.
FDG PET/CT Utility in Gynecologic Malignancies: A comprehensive review of anatomy, pathways of metastatic spread and scan findings
Emory University Hospital
Our objective was to review the five major gynaecologic cancers (cervical, ovarian, uterine, vaginal, and vulvar) and demonstrate the role of FDG PET/CT in diagnosis, surveillance, FIGO staging and treatment strategy.
FDG PET/CT Characteristics of Adrenal Benign and Malignant Lesions
Emory University Hospital
We selected FDG PET/CT cases with strong key representative findings to help illustrate benign and malignant adrenal lesions. Tabular review of PET SUV values, Hounsfield units and lesion size in the different cases will be discussed.
Discovery of Conserved Domains for Development of Functional Markers and Identification of microRNAs from Drought Responsive Expressed Sequence Tags (ESTs) in Chickpea (Cicer arietinum L.)
DOR, Hyderabad
This stidy identified that conserved domains or gene families from the ESTs could be utilized for the identification of gene-targeted markers and for development of functional markers to accelerate marker assisted backcross breeding in chickpea.
Mohamad Al-shammari wins Poster Award at System Biology Europe 2012
University of Bradford
Mohamad Al-shammari wins Poster Award at System Biology Europe 2012
Gene Expression from Pseudourine and 5-Methylcytidine Modified Messenger RNA
TriLink BioTechnologies, Inc.
Study objective was to develop methodologies for gram scale synthesis of messenger RNA (mRNA) for gene therapy applications, as well as scalable purification methods that yield highly expressed, persistent and non-toxic mRNA.
A Dynamic Glucose-Sensitive Insulin Delivery System: poly(NIPAm/MAA) Nanoparticle Membrane
Bergen County Academies
It can be stated that there exists a spatial and temporal differential paradox of dynamic glucose levels in the body. Conventional insulin injections are unable to resolve this paradox.
Random Homozygous Gene Perturbation (RHGP) as a Tool for Target Discovery and Validation
Functional Genetics
Random homozygous gene perturbation (RHGP) can identify and validate any host (cellular) gene target that directly causes a desired phenotype without requiring prior knowledge of the target. The central feature of RHGP is a unique lentiviral-based genetic element, known as a gene search vector (GSV) designed to interrogate the entire genome and identify target genes that cause the phenotype of interest.
Simultaneous RT-qPCR Measurement of 1718 Long Non-Coding RNAs
biogazelle
Massively parallel RNA-sequencing revealed that the human genome is pervasively transcribed, resulting in the production of thousands of non-coding RNA transcripts.
NHS
This study aims to explore the discrepancy between the increasing array of treatments for cancer pain, as well as the evidence that it can be managed effectively in the majority of cases, and its persisting prevalence.
Evaluation of 2012 Bowel Cancer Awareness and Early Diagnosis Campaign at a District General Hospital
Brighton and Sussex University Hospitals
Following the regional Be Clear on Cancer campaign, the Department of Health launched a national bowel cancer awareness campaign from 30 January 2012. The campaign ran until the end of March.
FDG PET/CT Utility in Gynecologic Malignancies: A comprehensive review of anatomy, pathways of metastatic spread and scan findings
Emory University Hospital
Our objective was to review the five major gynaecologic cancers (cervical, ovarian, uterine, vaginal, and vulvar) and demonstrate the role of FDG PET/CT in diagnosis, surveillance, FIGO staging and treatment strategy.
FDG PET/CT Characteristics of Adrenal Benign and Malignant Lesions
Emory University Hospital
We selected FDG PET/CT cases with strong key representative findings to help illustrate benign and malignant adrenal lesions. Tabular review of PET SUV values, Hounsfield units and lesion size in the different cases will be discussed.
Discovery of Conserved Domains for Development of Functional Markers and Identification of microRNAs from Drought Responsive Expressed Sequence Tags (ESTs) in Chickpea (Cicer arietinum L.)
DOR, Hyderabad
This stidy identified that conserved domains or gene families from the ESTs could be utilized for the identification of gene-targeted markers and for development of functional markers to accelerate marker assisted backcross breeding in chickpea.
Mohamad Al-shammari wins Poster Award at System Biology Europe 2012
University of Bradford
Mohamad Al-shammari wins Poster Award at System Biology Europe 2012
Gene Expression from Pseudourine and 5-Methylcytidine Modified Messenger RNA
TriLink BioTechnologies, Inc.
Study objective was to develop methodologies for gram scale synthesis of messenger RNA (mRNA) for gene therapy applications, as well as scalable purification methods that yield highly expressed, persistent and non-toxic mRNA.
A Dynamic Glucose-Sensitive Insulin Delivery System: poly(NIPAm/MAA) Nanoparticle Membrane
Bergen County Academies
It can be stated that there exists a spatial and temporal differential paradox of dynamic glucose levels in the body. Conventional insulin injections are unable to resolve this paradox.
Random Homozygous Gene Perturbation (RHGP) as a Tool for Target Discovery and Validation
Functional Genetics
Random homozygous gene perturbation (RHGP) can identify and validate any host (cellular) gene target that directly causes a desired phenotype without requiring prior knowledge of the target. The central feature of RHGP is a unique lentiviral-based genetic element, known as a gene search vector (GSV) designed to interrogate the entire genome and identify target genes that cause the phenotype of interest.
Simultaneous RT-qPCR Measurement of 1718 Long Non-Coding RNAs
biogazelle
Massively parallel RNA-sequencing revealed that the human genome is pervasively transcribed, resulting in the production of thousands of non-coding RNA transcripts.
Automating Aqueous Compound Solubility Using the 96-Well Multiscreen® Solubility Filter Plate on a Hamilton Microlab® Star Workstation
Hamilton
Here we describe an automated method for determining drug solubility using Millipore’s MultiScreen Solubility filter plate on the Hamilton MICROLAB STAR workstation.
A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
BMG LABTECH
Post-translational histone modifications like acetylation play a pivotal role in the epigenetic regulation of transcription. Catalyzing the latter reaction HDACs affect various cellular processes especially cancerogenesis. Although the mechanism of starting cancerogenesis by epigenetic events is not clearly explained inhibition of HDACs has highlighted as a viable principle in cancer therapy.
Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices
Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.
Sequence-Specific DNA Assay
Molecular Devices
The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices
The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition
BMG Labtech
Pgp expression has been linked to the effl ux of chemotherapeutic drugs in human cancers leading to multidrug resistance. Pgp activity can also result in low oral absorption and poor brain penetration. Interaction of drugs with the Pgp may also cause an increase in toxicity of co-administered compounds.
Validated Luminometric DLR™ Reporter Gene Assay with Thermo Scientific Varioskan® Flash
Thermo Fisher Scientific
One of the most common luminometric assays is Dual Luciferase® Reporter Assay from Promega corp. This application note shows how this assay is performed with Varioskan Flash multitechnology microplate reader. The note includes the performance of the normal DLR assay and results from some tests showing important aspects of the basic behaviour and performance of the DLR™ chemistry. This paper describes the overall efficiency of the Varioskan Flash in the measurement of DLR assay.
FabRICATOR® - perfect F(ab?)2 fragments in minutes
Genovis
Fab and F(ab?)2 antibody fragments are used in applications or assays where the presence of the Fc region may cause problems. If antibodies are used for staining of a specific target in tissues like spleen, lymph or in peripheral blood preparations, cells with Fc receptors (macrophages, monocytes, natural killer cells and B lymphocytes) can bind to the Fc region of the antibody and cause a background staining in areas that do not contain any antigen. Fab and F(ab?)2 fragments are also desirable
DNA Transfection with High Transfection Efficiency and Low Toxicity Using NIMT®FeOfection
Genovis
Transfection of DNA is used to analyze and study functions of genes, regulatory sequences and metabolism in living cells. To study cells and the effects of the gene transfer researchers need methods that give high transfection efficiencies, during a period of time and with low toxicity. Lipid based transfection agents often generates good transfection rates but with high toxicity. Here the novel NIMT®FeOfection transfection agents are tested for its ability to transfect different cell types and
Efficient Delivery of siRNA in Human Renal Cell Carcinoma Cell Line Using NIMT®FeOfection | PURPLE
Genovis
Short interfering RNA (siRNA) transfection is an exciting new method for introducing foreign genetic information by inducing RNA interference. siRNA works by silencing key sequences on messenger RNA, which turns off specific genes by cleaving them on the RNA strand. For this process to work efficiently one of the key steps is delivery of the siRNA into cells. Here, novel siRNA delivery agent NIMT®FeOfection|PURPLE is tested for its ability to deliver siRNA.
Hamilton
Here we describe an automated method for determining drug solubility using Millipore’s MultiScreen Solubility filter plate on the Hamilton MICROLAB STAR workstation.
A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
BMG LABTECH
Post-translational histone modifications like acetylation play a pivotal role in the epigenetic regulation of transcription. Catalyzing the latter reaction HDACs affect various cellular processes especially cancerogenesis. Although the mechanism of starting cancerogenesis by epigenetic events is not clearly explained inhibition of HDACs has highlighted as a viable principle in cancer therapy.
Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices
Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.
Sequence-Specific DNA Assay
Molecular Devices
The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices
The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition
BMG Labtech
Pgp expression has been linked to the effl ux of chemotherapeutic drugs in human cancers leading to multidrug resistance. Pgp activity can also result in low oral absorption and poor brain penetration. Interaction of drugs with the Pgp may also cause an increase in toxicity of co-administered compounds.
Validated Luminometric DLR™ Reporter Gene Assay with Thermo Scientific Varioskan® Flash
Thermo Fisher Scientific
One of the most common luminometric assays is Dual Luciferase® Reporter Assay from Promega corp. This application note shows how this assay is performed with Varioskan Flash multitechnology microplate reader. The note includes the performance of the normal DLR assay and results from some tests showing important aspects of the basic behaviour and performance of the DLR™ chemistry. This paper describes the overall efficiency of the Varioskan Flash in the measurement of DLR assay.
FabRICATOR® - perfect F(ab?)2 fragments in minutes
Genovis
Fab and F(ab?)2 antibody fragments are used in applications or assays where the presence of the Fc region may cause problems. If antibodies are used for staining of a specific target in tissues like spleen, lymph or in peripheral blood preparations, cells with Fc receptors (macrophages, monocytes, natural killer cells and B lymphocytes) can bind to the Fc region of the antibody and cause a background staining in areas that do not contain any antigen. Fab and F(ab?)2 fragments are also desirable
DNA Transfection with High Transfection Efficiency and Low Toxicity Using NIMT®FeOfection
Genovis
Transfection of DNA is used to analyze and study functions of genes, regulatory sequences and metabolism in living cells. To study cells and the effects of the gene transfer researchers need methods that give high transfection efficiencies, during a period of time and with low toxicity. Lipid based transfection agents often generates good transfection rates but with high toxicity. Here the novel NIMT®FeOfection transfection agents are tested for its ability to transfect different cell types and
Efficient Delivery of siRNA in Human Renal Cell Carcinoma Cell Line Using NIMT®FeOfection | PURPLE
Genovis
Short interfering RNA (siRNA) transfection is an exciting new method for introducing foreign genetic information by inducing RNA interference. siRNA works by silencing key sequences on messenger RNA, which turns off specific genes by cleaving them on the RNA strand. For this process to work efficiently one of the key steps is delivery of the siRNA into cells. Here, novel siRNA delivery agent NIMT®FeOfection|PURPLE is tested for its ability to deliver siRNA.
