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  Events - November 2012


Introduction to Photostability

23 Nov 2012 - 23 Nov 2012 - Islington, London,



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Course objectives
All PharmaTraining courses focus on two key objectives. These are to provide attendees with knowledge - information, which will assist you in making better judgements - and skills, which will allow you to apply the knowledge you have received. We guarantee to engage your interest and commitment on the course, and we expect our training to improve your effectiveness.

About this course
The purpose of this course is to give an overview of photostability,and where it fits in the stability testing programme and the importance of photostability. The course is highly interactive and held in a relaxed environment.

It will cover:
. Why do we do photostability tests?
. Concepts and background in photostability
. Identifying drug substances most likely to absorb light and display signs of poor photostability
. Understanding photostability terminology
. Where does phototstability fit in the overall stability testing program?
. Why does photostability matter? (exercise)

Who will benefit: The course is designed for people working in:
. Analytical Development
. Analytical Chemistry
. Stability Testing

Course Programme
Coffee and registration will be available from 8.30am, course proper will commence at 9.00am. We anticipate the course will finish at 5.00pm.

Formulating and manufacturing unstable products
. Formulation development and evaluation for photolabile materials
. Protection during the manufacturing process
. Getting the product to the patient

ICH guidelines for photostability testing: Using ICH Q1B guidance in practice
. understanding the terms and procedures used in the guideline

Practicalities
. Light source selection - Options 1 and 2
. Sample presentation
. Humidity and temperature control
. Selecting sample containers

Forced degradation: Practical and regulatory aspects of photostability
stress testing
. Selecting experimental conditions for stressing samples with respect to light
Meeting regulatory requirements
. Documentation – principles and practice
. Stability testing and the Quality System
. SOPs for stability testing
. Equipment validation and calibration – do the chambers work?
. Protocol development and approval
Reporting stability test data
Delegate Workshop
Problems and issues for discussion

Additional Resources
Online access to comprehensive publications including all relevant guidance will be provided as well as colour copies of all presentations and case studies.
. Technical Operations
. Research and Development Chemistry
. QA/QC
. Formulation Development
. Pharmaceutical & Biopharmaceutical Manufacturing/Production
. Product Development
. Regulatory Affairs
. GLP/GMP Compliance

Speaker:
Dr Michael Gamlen is Managing Director of Pharmaceutical Development Services Ltd, a pharmaceutical consultancy based in Nottingham (UK). Dr Gamlen has over 30 years experience of product stability testing. Awarded a First Class Honours degree in Pharmacy, specialising in Pharmaceutical Engineering, he studied for a PhD at Nottingham University. He was Head of Tablet Development at the The Wellcome Foundation for 15 years, and worked as an outsourcing manager before starting his consultancy business in 2000. Dr Gamlen specialises in managing product development, formulation, tablet and process development studies. He has been teaching professional tabletting courses for many years and his courses are highly rated, exceeding the expectation of the participants in many cases.

Michael continually updates the content of his courses with the latest guidance and extracts of up-to-the minute scientific papers. He provides a substantial body of relevant literature to all course participants as well as copies of all notes and guidance used and a workbook. He is a popular and highly respected presenter.



Further information
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Self-Assembling, Biomimetic Membranes May Aid Water Filtration
A synthetic membrane that self assembles and is easily produced may lead to better gas separation, water purification, drug delivery and DNA recognition, according to an international team of researchers.
Error Correction Mechanism in Cell Division
Cell biologists have reported an advance in understanding the workings of an error correction mechanism that helps cells detect and correct mistakes in cell division early enough to prevent chromosome mis-segregation and aneuploidy, that is, having too many or too few chromosomes.
Researchers Resurrect Ancient Viruses
Researchers at Massachusetts Eye and Ear and Schepens Eye Research Institute have reconstructed an ancient virus that is highly effective at delivering gene therapies to the liver, muscle, and retina.
Cell Aging Slowed by Putting Brakes on Noisy Transcription
Experiments in yeast hint at ways to extend life of some human cells.
Crucial for Stem Cell Survival Protein Identified Using Editing Tool CRISPR
A team of University of Wisconsin-Madison engineers has identified a protein that is integral to the survival and self-renewal processes of human pluripotent stem cells (hPSC).
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
A Gene-Sequence Swap Using CRISPR to Cure Haemophilia
For the first time chromosomal defects responsible for hemophilia have been corrected in patient-specific iPSCs using CRISPR-Cas9 nucleases
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