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Webcasts
Webcast - The Tip of the Iceberg - How Pipette Tips Influence Assay ResultsThe Tip of the Iceberg - How Pipette Tips Influence Assay Results
n this webinar, you will learn everything you need to know about pipette tips and the huge impact they can have on your results.
Webcast - Pipette calibration - DonPipette calibration - Don't risk your results!
In this educational webinar, you will learn why the calibration of liquid handling instruments is important, how calibration is performed in a professional service center and which instruments should be calibrated on a regular basis.

Market Reports
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
MicroRNAs and Exosomes
Select Biosciences Ltd

In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
MicroRNA Market Trends 2011
Select Biosciences Ltd

In this report, we focus upon the microRNA marketplace via primary market research that allows us to identify qualitative and quantitative trends from the bottom-up.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd

In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Circulating Tumor Cells (CTCs) Market Trends 2011
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the circulating tumor cells (CTCs) space. In this report, we focus upon the emerging marketplace for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastasis and mechanisms thereof.
Single Cell Omics 2011
Select Biosciences Ltd

The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights

This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Cancer Vaccines & Circulating Tumor Cells (CTCs) 2011 Report
Select Biosciences Ltd

This market report from Select Biosciences presents a comprehensive industry analysis of the cancer vaccines space as well as that of the emerging circulating tumor cells (CTCs) space. These two areas are evolving and expanding driven by the greater emphasis on personalized medicine especially in the cancer/oncology space.
MicroRNA Research and Disease Associations 2010 Market Report
Select Biosciences Ltd

This report contains primary market data characterizing the microRNA research marketplace including market penetrance of different research product vendors into the end-user community, products for microRNA research in the various market segments, research market characteristics—number of experiments performed, research product pricing, segmentation of the microRNA research market across various research areas, and unmet market needs.
Scientific News
Featured Article
Cancer Genetics: Key to Diagnosis, Therapy
When applied judiciously, cancer genetics directs caregivers to the right drug at the right time, while sparing patients of unnecessary or harmful treatments.

New Mechanism to Control Human Viral Infections Discovered
Researchers discover long sought after mechanism in human cells that could help treat diseases caused by viruses.
Study Reveals New Role for Hippo Pathway in Suppressing Cancer Immunity
Hippo pathway signaling regulates organ size by moderating cell growth, apoptosis and stem cell renewal, but dysregulation contributes to cancer development.
RNAi Activated in Response to Influenza
Discovery could lead to better ways of combating serious infections, including Ebola and Zika.
Gene Therapy Maintains Clotting Factor for Hemophilia Patients
Following a single gene therapy dose, the highest levels of an essential blood clotting factor IX were observed in hemophilia B patients.
Transporting Microscopic Cargo Between Human Cells
Scientists have developed a virus-inspired delivery system for material transport between cells.
Improving Drug Production with Computer Model
A model has been developed that can be used to improve and accelerate the production of biotherapeutics, cancer drugs, and vaccines.
Turning Off Asthma Attacks
Researchers discover a critical cellular “off” switch for the inflammatory immune response that causes asthma attacks.
New Strategy May Drop Cancer’s Guard
Scientists eye ways to deconstruct tumors’ protective wall with current diabetes drug.
Scientists Identify Unique Genomic Features in Testicular Cancer
The findings may shed light on factors in other cancers that influence their sensitivity to chemotherapy.
Business News
NantHealth, Oncotest-Teva Signs Reseller Deal
Collaboration aims to distribute its GPS Cancer molecular test in Israel.
Tempus, Penn’s Abramson Cancer Center Collaborate
Collaboration aims to better determine which patients will have a positive response to immunotherapy treatment based on next generation genomic and transcriptomic sequencing.
Cofactor Genomics, FLX Bio Partner
Partnership aims to develop a novel RNA-based IO analysis platform.
Parker Institute, CRI Announces Collaboration on Cancer Neoantigens
This new collaboration, the Tumor neoantigEn SeLection Alliance, includes 30 of the world’s leading cancer neoantigen research groups from both academia and industry.
Trovagene, Boreal Genomics Collaborate
Collaboration aims to co-develop urine and blood ctDNA assay kits.
City of Hope, TGen Collabotare
Collaboration aims to advance precision medicine and speed translational research.
VA, PCF Collaborate
Collaboration aims to prevent, screen and promote research to speed the development of treatments and cures for prostate cancer among Veterans.
GTG, The University of Melbourne Collaborate
Collaboration aims to develop colorectal cancer risk assessment test.
VA, Prostate Cancer Foundation Partner to Expand Clinical Research
The Department of Veterans Affairs and the Prostate Cancer Foundation partner to accelerate the development of treatments and cures for prostate cancer.
Oxford BioMedica, Orchard Therapeutics Announce Alliance
The alliance will develop and supply lentiviral vectors used by Orchard for the manufacture of ex-vivo gene therapy products.

Events
SLAS2017
04 Feb 2017
SLAS2017 ...
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2nd International Cancer Study
20 Feb 2017
2nd International Cancer Study ...
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RNA Therapeutics 2017
22 Feb 2017
RNA Therapeutics 2017 ...
More information
Phase Separation & RNA Process
24 Feb 2017
Phase Separation & RNA Process ...
More information

ePosters
Functional Analysis of RAD51B and RAD23B SNPs using Circular Chromosome Conformation Capture (4C) in Human Prostate Cell Lines
[sup}1.[/sup} The Institute of Cancer Research, 123 Old Brompton Road, London, UK 2.The Royal Marsden NHS Foundation Trust, Fulham Road, London, UK

The aim of this study is to understand the mechanism behind the association between single nucleotide polymorphisms (SNPs), lying in non-coding regions near or within RAD51B and RAD23B, and prostate cancer risk by analysing their interactions with the whole genome using Circular Chromosome Conformation Capture (4C).
Microfluidic extrusion of cell-laden hydrogel fibers for 3D-Bioprinting
CLNS - iit@Sapienza - Viale Regina Elena 291 - 00161 - Roma

An overview on how the incorporation of microfluidic platforms in 3D-bioprinters can open new routes in the creation of heterogeneous, tissue-specific bio-constructs and in the high-throughput screening of bioinks compositions for regenerative medicine and in vitro tissue modeling.
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
GE Healthcare Dharmacon, Inc.

Chemical synthesis has been easily applied for rapidly generating either crRNA and tracrRNA or synthetic sgRNA for direct delivery into cells for gene editing applications such as DNA-free options and high throughput arrayed screening.
The Chemical Synthesis of Long and Highly Modified RNA using 2'-ACE Chemistry
GE Healthcare Dharmacon, Inc.

Dharmacon has previously developed a novel RNA synthesis chemistry making RNA synthesis as reliable, accessible and of comparable quality as routinely observed in DNA synthesis.
Blood Transcriptomic Diagnosis of Active TB with Five Genes
1Infection & Immunity, University College London, UK 2Department of Microbiology, University College London Hospitals NHS Trust, UK 3Blizard Institute, Queen Mary Univ

This study aimed to identify the minimal set of genes that can accurately diagnose active TB, both pulmonary and extrapulmonary, and evaluate their specificity.
Experimental design considerations for efficient and specific gene knockin using a CRISPR-Cas9 for HDR with synthetic crRNA and tracrRNA
Dharmacon, part of GE Healthcare

Precise genome engineering with CRISPR-Cas9 and single-stranded DNA oligo or double-stranded DNA plasmid donors via homology-directed repair (HDR).
Super-resolution single molecule localization microscopy of the exocytotic machinery underlying insulin secretion.
Heriot-Watt Univeristy

Single molecule imaging of the tSNARE proteins involved in insulin secretion.
Resistance-Associated Variants in HCV Genotype 1 Populations
1Vela Diagnostics Pte. Ltd., Singapore; 2Molecular Diagnosis Centre, Department of Laboratory Medicine, National University Hospital, Singapore; 3Department of Patholo

In this study we specifically investigated RAVs emerging in HCV genotype 1.
Integrated Next-Generation Sequencing and qPCR Workflow in Clinical Diagnostics
Vela Diagnostics Pte. Ltd., Singapore

Combined automated qPCR and NGS Sentosa workflow is a reliable and efficient in vitro diagnostics (IVD) tool for the detection and/or quantitation of a wide range of bacterial and viral pathogens as well as gene mutations.
A Synthetic CRISPR-Cas9 System for Homology-directed Repair
Dharmacon (part of GE Healthcare)

Synthetic, dual-RNA-encoded Cas9 is used for precise homology-directed repair (HDR) gene engineering. Both short and long (GFP) inserts are covered.
Application Notes
Using DSC to Characterize Thermotropic Phase Transitions in Lipid Bilayer Membranes
Malvern Instruments Limited

The basics of liposome sample preparation and DSC studies.
A Novel Lipid Screening Platform that Provides a Complete Solution for Lipidomics Research
SCIEX

The Lipidyzer™ Platform, powered by Metabolon®.
Novel Chemical Standards Kits Enable Facile Lipid Quantitation
SCIEX

The Lipidyzer platform provides more accurate lipid analysis with less quantitative bias.
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Determining the Fluorescence Limit of Detection for a Given Flourophore
Malvern Instruments Limited

This note works through an experiment to approximately establish a baseline in terms of the fluorescence limit of detection for a given fluorophore.
Assessing Drug Encapsulation Efficiency using Nanoparticle Tracking Analysis
Malvern Instruments Limited

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Automated Illumina NGS Sample Preparation: TruSeq® Stranded mRNA on the Hamilton Microlab STAR
Hamilton Robotics

Illumina’s sample preparation kits produce high quality libraries for DNA and RNA sequencing. Hamilton offers the robust Microlab STAR line of robotic liquid handling workstations for automating sample preparation. Together, the automation of the TruSeq Stranded mRNA sample preparation protocol on the STAR gives the user hours of reliable, unattended library preparation.
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