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Bone Marrow-on-a-Chip...
An ULTImate Y2H project at Hybrigenics S...PGS 24 Chromosomes...Virus-inspired DNA Nanodevices...

Featured Products
Featured Product - Streamlining ChIP for qPCR Analysis
Streamlining ChIP for qPCR Analysis
Featured Product - QuantiSir Specific Gene Knockdown Quantification Kit For Tumor Suppressors/Oncogenes
QuantiSir Specific Gene Knockdown Quantification Kit For Tumor Suppressors/Oncogenes

Webcasts
Webcast - Discovery of Potent and Selective Inhibitors of Monopolar Spindle 1 (MPS1) KinaseDiscovery of Potent and Selective Inhibitors of Monopolar Spindle 1 (MPS1) Kinase
Rob van Montfort, The Institute of Cancer Research, speaking at Discovery Chemistry Congress 2015.
Webcast - Fit-for-Purpose Biomarker Assay Validation - From Research Tool to Diagnostic TestFit-for-Purpose Biomarker Assay Validation - From Research Tool to Diagnostic Test
Jeff Cummings, Cancer Research UK, speaking at Diagnostics & Biomarkers 2015.

Market Reports
RNAi
RI Technologies

The report serves as a guide to global RNAi industry covering 280 plus companies that are engaged in RNAi synthesis, R&D, therapeutics, test kits, tools and services.
Innovation in the Prefilled Syringe Market - Biologics and Autoinjection Devices Shaping Future R&D Trends
Global Data

The report provides insights into possible future avenues of R&D in the prefilled syringe market. This includes an overview of problems and possible solutions, as well as discussion of how the devices have developed to date to address problems with contamination, safety, fragility and ease of use.
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018
GBI Research

The currently marketed monoclonal antibodies are highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. Significant market exclusivity, expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.
qPCR Assay Trends 2013
HTStec

HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
siRNA Screening Trends
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on siRNA screening carried out in September 2012.
MicroRNAs and Exosomes
Select Biosciences Ltd

In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
MicroRNA Market Trends 2011
Select Biosciences Ltd

In this report, we focus upon the microRNA marketplace via primary market research that allows us to identify qualitative and quantitative trends from the bottom-up.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd

In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Circulating Tumor Cells (CTCs) Market Trends 2011
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the circulating tumor cells (CTCs) space. In this report, we focus upon the emerging marketplace for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastasis and mechanisms thereof.
Scientific News
It Runs in the Family
Distantly related viruses share a common machinery for replication.
Inexpensive Technique Developed to Manufacture Nanofibers
Current methods for producing nanofibers are incredibly costly and therefore limit accessibility, this new study opens the door to cheap, mass produced nanofibers.
Normal Skin Accrues High Number of Mutations Associated with Cancer
Researchers used genomic sequencing to gain insights into how somatic mutations build up in normal cells before the onset of cancer, a process that is poorly understood.
New Device May Shed Light on Why Cancer Cells Metastasize
Scientists from the University of Michigan think they are now a step closer to understanding why some cancer cells metastasize.
Could GM Lettuce Fight Cancer?
New research in the controversial field of genetic modification points to lettuce as a vector for delivering microRNA to combat cancer.
Designing Better Medical Implants
A team of MIT researchers have discovered a novel method for reducing the typical immune system rejection response when implanting biomedical devices into the body.
Laser Technique for Self-Assembly of Nanostructures
Researchers have developed a low-cost technique that holds promise for a range of scientific and technological applications.
Smoking Signs
Research reveals epigenetic alterations caused by smoking.
Microchip Captures Clusters of Circulating Tumor Cells
Researchers have developed a microfluidic chip that can capture rare clusters of circulating tumor cells, which could yield important new insights into how cancer spreads.
One Molecule at a Time
The ability to study single molecules provides tangible targets for personalised medicine.
Business News
UT Southwestern Faculty Members Named HHMI Investigators
Appointment of Dr. Kim Orth and Dr. Joshua Mendell to HHMI.
Vermillion Awarded $7.5M Grant
The grant awarded is to aid the development of a multi-site pelvic mass registry.
Comprehensive Biomarker Center GmbH Accredited by German DAkkS
DIN EN ISO/IEC 17025:2005 accreditation to analyze RNA-based biomarkers from body fluids.
HedgePath Pharmaceuticals To Receive $2.5 Million in Funding
The company plan to use this new funding to immediately accelerate their cancer treatment research.
Johnson & Johnson Expects Lucrative Return on Drug Pipeline
Following the recent announcement of a number of collaborations and upcoming projects, the company hope their pharmaceutical business will continue to grow.
GeneNews, Cobalt Healthcare Buy Out HDL's Stake in CLIA Lab JV
GeneNews and Cobalt Healthcare announce they will now be 50 percent stake holders following the buy out.
BioNTech, Genmab Launch Up-to-$15M Collaboration
This recently announced partnership will see the companies jointly research, develop and commercialize cancer immunotherapies.
Abcodia Secures £5.25M Funding
Investment enables the launch of the ROCA® test for early detection of ovarian cancer in US and UK in 2015, as well as the establishment of a US presence.
Genzyme, Ablynx Launch MS Collaboration
Genzyme has agreed to use Ablynx's therapeutic proteins to carry out in vitro and in vivo research on multiple sclerosis models, then develop therapies against the disease.
Mayo, Baylor Collaborate
They aim to study genomic links to drug metabolism and other interactions which could be used to provide more tailored patient care.

Events
Target Cancer Metabolism
26 May 2015
Target Cancer Metabolism ...
More information
63rd ASMS Conference on Mass S
31 May 2015
63rd ASMS Conference on Mass S ...
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The 2nd Due Diligence Summit f
09 Jun 2015
The 2nd Due Diligence Summit f ...
More information
Regulating with RNA in Bacteri
09 Jul 2015
Regulating with RNA in Bacteri ...
More information

ePosters
Bovine RNA-seq data analysis of liver and pituitary gland
(1) Functional Genomics Lab. Faculty of Biology and Environmental Protection, Nicolaus Copernicus University, Torun, Poland, (2) Interdisciplinary Centre of Modern Technology, Nicolaus Copernicus Uni

Two key applications of RNA-seq i.e., i) transcriptome read mapping to a reference genome and ii) SNP detections were investigated to analysis of bovine liver and pituitary gland transcriptome. Here, we have presented ONLY the obtained results of bovine pituitary gland.
Innovative technology that enables RNAi in difficult to transfect cells
GE Healthcare Dharmacon, Inc.

Investigations at Dharmacon have led to the development of innovative siRNA molecules that can be delivered into difficult-to-transfect cells without additional lipid reagents, virus, or instruments. This technology, Accell siRNA reagents, enables gene knockdown for functional genomic studies in a wide variety of cell types. In some instances, cells can be continuously dosed with Accell siRNAs to enable target gene knockdown for extended durations.
THe AtSCL26 transcription factor controls cross-talk between GA and N root architecture in Arabidopsis thaliana roots
University of Warwick

Phenotypic and molecular evidence supports the hypothesis that developmental program enabling nodule formation arose during evolution from a lateral root ‘blueprint’ pre-existing in all higher plants . We reasoned that analyzing Arabidopsis genes orthologous to regulators of nodulation could shed insight on control of lateral root development. This led us to the discovery that an Arabidopsis GRAS family transcription factor controls lateral root development under specific nitrogen conditions.
LOHA Comprehensive Assay for Single Nucleotide Polymorphism, Copy Number Variants and Loss of Heterozygosity Using SureSelect Target Enrichment
Agilent Technologies, Diagnostics and Genomics Group

Here we describe a comprehensive assay that enables researchers to identify SNP, INDEL, CNV, and LOH using SureSelect target enrichment. This design can be employed as a standalone entity or in concert with other bait designs for SNP and INDEL detection. We also describe methods for data analysis and visualization.
An examination of specific cellular organelle-targeting nanotags using combined 3D Raman and SERS imaging
Renishaw plc,

We investigated the specific targeting of endoplasmic reticulum and trans-Golgi network in Chinese hamster ovarian cells using functionalised nanotags. The targeting was examined using the combined 3D SERS and Raman imaging method.

SOFT DEVICES FOR HEALTHCARE MONITORING APPLICATIONS
CETEMMSA

Printed Electronics allow the creation of new and innovative functionalized textile products, in the demanding and highly specialized world of Medical Devices. The main aim of this whole new sector is to produce wearable, conformable, flexible and low-cost textile-based devices bringing innovative solutions to different markets.
The Power Decoder simulator for the evaluation of pooled shRNA screen performance
GE Healthcare Dharmacon, Inc.

Power Decoder (written in R and Python) simulates shRNA pooled screening experiments in silico to allow for the estimation of a screen’s statistical power. Populations of shRNAs were engineered in such a way that the magnitude of depletion and enrichment was known, then using the negative binomial distribution, an in silico model was developed to successfully resemble data from an actual laboratory experiment.
Knockdown of long noncoding RNAs in breast cancer
GE Healthcare Dharmacon, Inc.

RNAi global collaboration study using Lincode siRNA in a primary screen of tumor and nontumor breast cell lines. Hundreds of lncRNAs are found to affect viability and cell morphology of breast cancer. Presented at Keystone Symposia on Long Noncoding RNAs: From Evolution to Function, Mar 15 - Mar 20, 2015.
Improved Small RNA Library Preparation Workflow for Next-Generation Sequencing
TriLink BioTechnologies

We describe an optimized small RNA NGS library prep workflow using chemically modified adapters which suppresses adapter dimers, allows for RNA inputs down to 1 ng and eliminates the need for a gel purification step, thus allowing full automation not previously possible.
Fluorescent Nanoprobes Confined in a Drop as a novel Sensing Platform for Detection of Metal Species at Trace Level
University of Vigo (Spain)

In the last years, a great interest has arisen concerning the design and development of new optical probes for the sensitive and selective detection of chemical species making use of miniaturized and environmental friendly methods. In this sense, quantum dots (QDs) and metal nanoclusters (NCs) have important optical properties to be applied in analytical systems as fluorescent probes.
Application Notes
Assessing Drug Encapsulation Efficiency using Nanoparticle Tracking Analysis
Malvern Instruments Limited

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Automated Illumina NGS Sample Preparation: TruSeq® Stranded mRNA on the Hamilton Microlab STAR
Hamilton Robotics

Illumina’s sample preparation kits produce high quality libraries for DNA and RNA sequencing. Hamilton offers the robust Microlab STAR line of robotic liquid handling workstations for automating sample preparation. Together, the automation of the TruSeq Stranded mRNA sample preparation protocol on the STAR gives the user hours of reliable, unattended library preparation.
Automating Aqueous Compound Solubility Using the 96-Well Multiscreen® Solubility Filter Plate on a Hamilton Microlab® Star Workstation
Hamilton

Here we describe an automated method for determining drug solubility using Millipore’s MultiScreen Solubility filter plate on the Hamilton MICROLAB STAR workstation.
A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
BMG LABTECH

Post-translational histone modifications like acetylation play a pivotal role in the epigenetic regulation of transcription. Catalyzing the latter reaction HDACs affect various cellular processes especially cancerogenesis. Although the mechanism of starting cancerogenesis by epigenetic events is not clearly explained inhibition of HDACs has highlighted as a viable principle in cancer therapy.
Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.
Sequence-Specific DNA Assay
Molecular Devices

The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
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