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Featured Product - microRNA Purification Kit
microRNA Purification Kit

Webcasts
Webcast - Bacterial Genomic Changes Revealed through Next-generation Sequencing Data AnalysisBacterial Genomic Changes Revealed through Next-generation Sequencing Data Analysis
Lori Snyder, Kingston University, speaking at NSG & Big Data 2014
Webcast - A High Content Imaging Platform to Study Spatio-temporal Signaling Networks during Neuronal DifferentiationA High Content Imaging Platform to Study Spatio-temporal Signaling Networks during Neuronal Differentiation
Olivier Pertz, University of Basel, speaking at High Content Analysis 2014

Market Reports
RNAi
RI Technologies

The report serves as a guide to global RNAi industry covering 280 plus companies that are engaged in RNAi synthesis, R&D, therapeutics, test kits, tools and services.
Innovation in the Prefilled Syringe Market - Biologics and Autoinjection Devices Shaping Future R&D Trends
Global Data

The report provides insights into possible future avenues of R&D in the prefilled syringe market. This includes an overview of problems and possible solutions, as well as discussion of how the devices have developed to date to address problems with contamination, safety, fragility and ease of use.
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018
GBI Research

The currently marketed monoclonal antibodies are highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. Significant market exclusivity, expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.
qPCR Assay Trends 2013
HTStec

HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
siRNA Screening Trends
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on siRNA screening carried out in September 2012.
MicroRNAs and Exosomes
Select Biosciences Ltd

In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
MicroRNA Market Trends 2011
Select Biosciences Ltd

In this report, we focus upon the microRNA marketplace via primary market research that allows us to identify qualitative and quantitative trends from the bottom-up.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd

In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Circulating Tumor Cells (CTCs) Market Trends 2011
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the circulating tumor cells (CTCs) space. In this report, we focus upon the emerging marketplace for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastasis and mechanisms thereof.
Scientific News
Scientists Identify New and Beneficial Function of Endogenous Retroviruses
Researchers found that ERV play a critical role in the body’s immune defense against common bacterial and viral pathogens.
Long Noncoding RNAs: A Novel Prognostic Marker in Older Patients with Acute Leukemia
This study describes a new marker that might help doctors choose the least toxic, most effective treatment for older patients with acute myeloid leukemia.
Proteins Drive Cancer Cells To Change States
When RNA-binding proteins are turned on, cancer cells get locked in a proliferative state.
Signaling Mechanism Could Be Target For Survival, Growth Of Tumor Cells In Brain Cancer
Non-canonical EGFR signalling shown to make glioblastoma tumor cells more resistant to chemotherapy treatment.
New Way To Turn Genes On
Technique allows rapid, large-scale studies of gene function.
CSHL Team Finds a Way to Make shRNA Gene Knockdown More Effective
A powerful algorithm that improves the effectiveness of an important research technology.
Genes that Cause Pancreatic Cancer Identified by New Tool
Screening system in mice spots cancerous changes invisible to sequencing.
A Yardstick to Measure the Malignancy of Prostate Cancer
Researchers have been searching for regulatory proteins that change the epigenetic characteristics of prostate cancer cells.
Genetic Errors Linked To Aging Underlie Leukemia That Develops After Cancer Treatment
New research by Daniel Link, MD, and colleagues at The Genome Institute at Washington University has revealed that mutations that accumulate randomly as a person ages can play a role in a fatal form of leukemia that develops after treatment for another cancer.
New Cause of Child Brain Tumour Condition Identified
Doctors and scientists have identified changes in SUFU gene which can cause Gorlin syndrome.
Business News
CMC Biologics and OncoSynergy Enter into an Agreement
Agreement for accelerated process development and GMP manufacture of an investigational drug to combat Ebola.
Curie-Cancer and GamaMabs Pharma Renew their Research Partnership
Clinical trials are scheduled for 2015 to explore the value of the candidate drug 3C23K in relapsing ovarian cancer.
OHSU and FEI Expand Living Lab with New Equipment for Cancer Research
Installation is part of an expansion of the OHSU/FEI Living Lab for Cell Biology collaboration.
BioLineRx Presents Multi-Year Clinical Development Plan for BL-8040
Clinical trials in three additional indications for BL-8040 to be initiated in 2015.
Takeda Announces Formalization of Takeda Oncology
Enhance discovery, development and global commercialization of cancer medicines.
4SC Reports Positive Topline Data from Clinical Phase I Trial with 4SC-205
4SC-205 is the only oral inhibitor of the Eg5 kinesin protein in clinical development worldwide. Eg5 plays a crucial role in cell division and tumour growth.
RainDance Forms Hematologic Oncology Consortium
HemOnc experts validate unmet need and performance of new ThunderBolts Myeloid NGS Panel at ASH 2014.
Immunocore and MedImmune Win the SCRIP Award
Immunocore and MedImmune are working together to generate ImmTACs against selected cancer targets.
New Companies Join Cancer Research UK Consortium
Three new biomarker companies have been selected to work with the Early Diagnosis Consortium, a collaboration between Cancer Research UK, its commercial arm, Cancer Research Technology and Abcodia.
GE Healthcare Licenses CRISPR Gene Engineering Technology Patents
Agreement will drive bioscience research by enabling development of novel Dharmacon genome engineering toolsets.

Events
Biomarkers from Research to Cl
15 Jan 2015
Biomarkers from Research to Cl ...
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Diagnostics & Biomarkers - DB
27 Jan 2015
Diagnostics & Biomarkers - DB ...
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RNA Therapeutics
16 Feb 2015
RNA Therapeutics ...
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8th Oncology Biomarker
18 Mar 2015
8th Oncology Biomarker ...
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ePosters
Experimental Evolution in Diatoms - Thermal longterm acclimation in two model diatom species
1 University of East Anglia, School of Environmental Science, Norwich, UK 2Institute of Evolutionary Biology, University of Edinburgh, Kings Building, Ashworth Laboratories, West

Experimental Evolution in two model Diatoms
Efficacy of Gene Therapy in Restoring Vision in Leber's Congenital Amaurosis
Open University

The research reviews current knowledge of the genetic causes of Leber's congenital amaurosis (LCA) and the development of a gene therapy intervention for LCA. The efficacy as well as the limitations of this form of treatment are evaluated in detail and recommendations are made for the future directions of gene therapy for Leber's congenital amaurosis.

Flow Enhancement and Dynamic of Microfluidic Base Biosensor
University Malaysia Pahang

The design of new biosesnor base on microfluidic system is presented. The design is consist of two chips, Microchannels chip and electrodes chip. By varying the size and optimizing the microchannels and electrode, the sensitivity of the biosensor will increase.
Recent Technical Developments in the Standardized Separation and Measurement of Extracellular Vesicles
(1) Izon Science US Ltd, Christchurch, New Zealand (2) The University of Queensland, Brisbane, QLD, Australia

We present robust and practical solutions for the standardization of EV isolation and concentration measurement. EV concentration also needs to have a defined size range. With these solutions, significant improvement in the reproducibility and comparability of results between different researchers is possible.
Artificial Multi-Gene Expression Systems Design Service for Natural Compound Formation and Hetero Protein Complexes
ATG:biosynthetics GmbH, IStLS

Drug discovery of natural compounds drug development and drug target analyses as well as bioproduction can benefit from artificial genetic systems and constructions. The direction in which genes are to be developed is written in the genomes. Synthesis oriented genomic analyses of codon bias and tRNA adaption analyses are prerequisites for generating adaptive, highly functional genes.
Identifying Molecular Signatures of Tumors Using Novel Fluorescence Resonance Energy Transfer Networks
Duke University

We developed FRET sensors that can detect 125 fluorophores simultaneously. From experimental analyses of over 1200 time-resolved fluorescence signatures on 300 prototypical sensors, we show that the optical responses are highly repeatable and minor variations between FRET networks can be discriminated resulting in a total of 10^375 unique responses in theory.

Liposomes and Nanoparticles as Delivery Vehicles for the Treatment of Lung Diseases
1Clemson University, Clemson, SC, 2Ralph H. Johnson VA Medical Center, Charleston, SC

Targeted nanoparticle-based drug delivery to the lungs is an emerging area of interest for both scientists and medical workers because it allows better drug retention in the lungs and can provide prolonged drug release. In our study we investigated the potential of using liposomes and polymeric nanoparticles surface modified with a specific antibody as drug carriers for targeted drug delivery to the lungs.
Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
Department of Chemistry, Virginia Tech,Virginia Tech Carilion Research Institute

We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.
Next Generation Multivalent PRINT Nanoparticle Vaccine Targeting Pneumococcal Disease
Liquidia Technologies, PATH

A new generation PRINT nanoparticle Pneumococcal vaccine matrix has been designed to mimic size and structural aspects of bacterial pathogens to efficiently present and deliver polysaccharide and protein antigens to elicit robust immune responses.
Print Nanoparticle Vaccine Carrying Bacterial Polysaccharide And Protein Antigens Induces Enhanced B- And T-Cell (Il-17) Immunity
1 Liquidia Technologies, 419 Davis Drive, Suite 100, Morrisville, NC 27560 2 PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA 98121 USA

Antigenic multivalent PRINT nanoparticle formulations leverage precise control of size, shape and composition, sterile filterability and scalable cGMP roll-to roll manufacturing to offering a low cost and simplified manufacturing advantage over traditional conjugate vaccines.
Application Notes
Assessing Drug Encapsulation Efficiency using Nanoparticle Tracking Analysis
Malvern Instruments Limited

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Automated Illumina NGS Sample Preparation: TruSeq® Stranded mRNA on the Hamilton Microlab STAR
Hamilton Robotics

Illumina’s sample preparation kits produce high quality libraries for DNA and RNA sequencing. Hamilton offers the robust Microlab STAR line of robotic liquid handling workstations for automating sample preparation. Together, the automation of the TruSeq Stranded mRNA sample preparation protocol on the STAR gives the user hours of reliable, unattended library preparation.
Automating Aqueous Compound Solubility Using the 96-Well Multiscreen® Solubility Filter Plate on a Hamilton Microlab® Star Workstation
Hamilton

Here we describe an automated method for determining drug solubility using Millipore’s MultiScreen Solubility filter plate on the Hamilton MICROLAB STAR workstation.
A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
BMG LABTECH

Post-translational histone modifications like acetylation play a pivotal role in the epigenetic regulation of transcription. Catalyzing the latter reaction HDACs affect various cellular processes especially cancerogenesis. Although the mechanism of starting cancerogenesis by epigenetic events is not clearly explained inhibition of HDACs has highlighted as a viable principle in cancer therapy.
Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.
Sequence-Specific DNA Assay
Molecular Devices

The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
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