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Featured Products
Featured Product - microRNA Purification Kit
microRNA Purification Kit
Featured Product - Streamlining ChIP for qPCR Analysis
Streamlining ChIP for qPCR Analysis

Webcasts
Webcast - Accelerate Your Research With Tecan´s New Multimode Microplate Reader Platform!Accelerate Your Research With Tecan´s New Multimode Microplate Reader Platform!
In this webinar, solutions will be presented for fast DNA quantification, single cell counting and viability analysis, and automating long-term live kinetic cell assays.
Webcast - Bacterial Genomic Changes Revealed through Next-generation Sequencing Data AnalysisBacterial Genomic Changes Revealed through Next-generation Sequencing Data Analysis
Lori Snyder, Kingston University, speaking at NSG & Big Data 2014

Market Reports
RNAi
RI Technologies

The report serves as a guide to global RNAi industry covering 280 plus companies that are engaged in RNAi synthesis, R&D, therapeutics, test kits, tools and services.
Innovation in the Prefilled Syringe Market - Biologics and Autoinjection Devices Shaping Future R&D Trends
Global Data

The report provides insights into possible future avenues of R&D in the prefilled syringe market. This includes an overview of problems and possible solutions, as well as discussion of how the devices have developed to date to address problems with contamination, safety, fragility and ease of use.
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018
GBI Research

The currently marketed monoclonal antibodies are highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. Significant market exclusivity, expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.
qPCR Assay Trends 2013
HTStec

HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
siRNA Screening Trends
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on siRNA screening carried out in September 2012.
MicroRNAs and Exosomes
Select Biosciences Ltd

In this report, we focus upon the microRNA research marketplace from the perspective of the translational opportunities in these spaces. The focus of this field is moving from basic research towards the utility of associations of microRNA expression patterns in disease.
MicroRNA Market Trends 2011
Select Biosciences Ltd

In this report, we focus upon the microRNA marketplace via primary market research that allows us to identify qualitative and quantitative trends from the bottom-up.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd

In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Circulating Tumor Cells (CTCs) Market Trends 2011
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the circulating tumor cells (CTCs) space. In this report, we focus upon the emerging marketplace for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastasis and mechanisms thereof.
Scientific News
Fighting the Colorado Potato Beetle with RNA
RNA interference protects potato plants against herbivore attack.
Acetate Supplements Shown to Speed Up Cancer Growth
A major compound produced in the gut by host bacteria.
Two Cell-Signaling Molecules Found to Suppress the Spread of Melanoma
Findings advance efforts to identify who would benefit from more aggressive therapy at earliest stages.
Single-Cell, 42-plexed Protein Analysis Achieved with a New Microchip Technology
A novel microdevice capable of detecting 42 unique immune effector proteins has been developed.
MAGE Genes Provide Insight into Optimizing Chemotherapy
UT Southwestern Medical Center scientists have identified a new biomarker that could help identify patients who are more likely to respond to certain chemotherapies.
Researchers Identify ‘Achilles heel’ in Metabolic Pathway
Achilles heel could lead to new lung cancer treatments.
New Resource to Study the Mechanism and Regulation of Autophagy
New online resource will provide an integrated and systems-level database for autophagy research.
Researchers Discover Possible Mechanism for Faster Evolution
Results hold great promise for gene therapy development.
Yale Team Identifies Key Process In Brain Development
miR-107 shown to play essential role in regulating normal brain development.
Cancer Treatment with KU Origins Enters Second Clinical Trial
Cleave Biosciences has begun a Phase 1 clinical trial to evaluate CB-5083.
Business News
BIOTECHNICA, LABVOLUTION and ELA: Strong Trio in October
Deutsche Messe AG to launch the new trade fair from 6 to 8 October this year.
Collaboration with MD Anderson Cancer Center on Colorectal Cancer
Collaboration to investigate the clinical use of ANGLE’s Parsortix system.
Dako; ONO Pharmaceutical Collaborate
Collaboration is for development of PD-L1 companion diagnostic test for investigational cancer drug Opdivo® (Nivolumab).
Bioo Scientific Partners with the Icahn School of Medicine at Mount Sinai
Partnership to reduce ligation bias in next generation sequencing.
Epistem Announces the Successful Evaluation of New RNA-AMP™ Technology
A highly sensitive and reproducible method to derive cDNA from picogram to nanogram quantities of RNA.
Maverix Wins $150,000 STTR Award
Award from The National Institute on Drug Abuse for detection of RNA modifications.
Consort Medical plc Signs Multi-Year Supply Agreement for IDC System
First agreement for oral variant of IDC-containing device.
Biogazelle has Established a Quality Management System
Company is ISO 17025 accredited for gene expression services.
AstraZeneca Forms CRISPR Collaborations
AstraZeneca announces collaborations to use CRISPR technology for genome editing across its drug discovery platform.
Nanotechnologies in Drug Delivery Conference
Technology Networks partners with MnM Conferences for their inaugural congress on Nanotechnologies in Drug Delivery.

Events
8th Oncology Biomarker
18 Mar 2015
8th Oncology Biomarker ...
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Oncology Leaders Forum 2015
24 Mar 2015
Oncology Leaders Forum 2015 ...
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Personalised Medicine
12 May 2015
Personalised Medicine ...
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BIT
15 May 2015
BIT's 8th Annual World Cancer ...
More information

ePosters
A multiplexed amplicon sequencing technology for FFPE and circulating, cell-free DNA
Swift Biosceinces

A novel amplicon approach allowing for hundreds of amplicons to be multiplexed in a single tube with a two workflow from sample to sequencer.
Stable Chloroplast: Myth or Reality?
South African Sugarcane Research Institute, School of Life Sciences, University of KwaZulu-Natal

Chloroplasts principally encode the photosynthetic machinery in Viridiplantae. It has long been accepted that in photosynthetic plants chloroplast genomic structure is uniquely stable as it is maternally and clonally inherited. The first chloroplast genomes sequenced supported this view. The current study was undertaken to address the potential issue of global chloroplast(in)stability.
Validation of Collection and Extraction Methods of Saliva for Use in Biomarker Research
Department of Pharmaceutical Sciences, South College School of Pharmacy, Knoxville, TN 37922

This poster investigates the collection and extraction methods of saliva for use in biomarker research.
Rapid Detection of Somatic Mutations in Cancer Genes
DiaCarta, Inc.

Rapid higly sensitive detection of tumor gene mutations in DNA derived from FFPE or plasma samples can be achieved with QClamp PCR technology.
Expression of Wnt5a in Urothelial Carcinoma as a Potential Prognostic Marker
1. OMSII; 2. Specialty Medicine; 3. Biomedical Sciences, HCOM

Our results support the previous studies that suggest Wnt5a plays a pathological role in urothelial carcinoma.
DHPLC Technology as a High-throughput Detection of Mutations in a Durum Wheat TILLING Population
1Department of Soil, Plant and Food Sciences, sect. Genetics and Plant Breeding, University of Bari, Via Amendola 165/A, 70126 Bari (Italy) 2 Transgenomics Omaha, NE, USA

This study is a beautiful example of DHPLC technology application and shows an alternative tool to current strategies of SNP detection based on genotyping array.
Population characterization of Brazilian isolates of Ceratocystis spp. using microsatellites
1Faculdade de ciências agronômicas, UNESP Botucatu, SP. Brazil   2Forestry and Agricultural Biotechnology Institute (FABI), Private Bag X20, University of Pretoria, Pretoria, 0028, South Africa

The genus Ceratocystis includes several species of economically important plant pathogens and has a global distribution. In Brazil, species in the genus cause disease and death of hosts such as cacao, eucalypts and mango. This study aimed to characterize the population structure and diversity of isolates of Ceratocystis fimbriata sensu lato collected from diseased Eucalyptus species and to compare these to isolates from cacao, mango, teak, fig, rubber and atemoya.
Geneious R8: A Powerful and Comprehensive Suite of Molecular Biology Tools

Biomatters, Inc & Biomatters, Ltd.

Geneious R8: A powerful and comprehensive suite of molecular biology tools.
Putative Genes Identified on Two Growth Conditions of G. boninense


Putative genes identified on two growth conditions of Ganoderma boninense.
TFAP2B is Associated with WNT/ß-catenin Pathway in Luminal Breast Cancer
1. Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Germany 2. Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Germany 3. Department of Clinica

Here we aimed to investigate which molecular mechanisms are associated with TFAP2B expression in luminal breast cancer.
Application Notes
Assessing Drug Encapsulation Efficiency using Nanoparticle Tracking Analysis
Malvern Instruments Limited

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Automated Illumina NGS Sample Preparation: TruSeq® Stranded mRNA on the Hamilton Microlab STAR
Hamilton Robotics

Illumina’s sample preparation kits produce high quality libraries for DNA and RNA sequencing. Hamilton offers the robust Microlab STAR line of robotic liquid handling workstations for automating sample preparation. Together, the automation of the TruSeq Stranded mRNA sample preparation protocol on the STAR gives the user hours of reliable, unattended library preparation.
Automating Aqueous Compound Solubility Using the 96-Well Multiscreen® Solubility Filter Plate on a Hamilton Microlab® Star Workstation
Hamilton

Here we describe an automated method for determining drug solubility using Millipore’s MultiScreen Solubility filter plate on the Hamilton MICROLAB STAR workstation.
A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
BMG LABTECH

Post-translational histone modifications like acetylation play a pivotal role in the epigenetic regulation of transcription. Catalyzing the latter reaction HDACs affect various cellular processes especially cancerogenesis. Although the mechanism of starting cancerogenesis by epigenetic events is not clearly explained inhibition of HDACs has highlighted as a viable principle in cancer therapy.
Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.
Sequence-Specific DNA Assay
Molecular Devices

The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
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