Corporate Banner
Satellite Banner
RNAi
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

RXi Pharmaceuticals Awarded NCI SBIR Funding

Published: Friday, October 12, 2012
Last Updated: Friday, October 12, 2012
Bookmark and Share
Company awarded approximately $300,000 to advance self-delivering RNAi technology.

RXi Pharmaceuticals Corporation has announced that it was awarded a Small Business Innovation Research (SBIR) grant by the National Cancer Institute (NCI) of the National Institutes of Health (NIH).

The grant provides funding for a project enabling the discovery and preclinical development of sd-rxRNAs® as potential therapy for retinoblastoma, a pediatric ocular malignancy.

The project will be completed in collaboration with Dr. David Cobrinik and colleagues at the Memorial Sloan-Kettering Cancer Center.

Dr. Cobrinik commented, "Prior studies performed by RXi and their collaborators at the University of Massachusetts, demonstrated that self-delivering sd-rxRNAs can penetrate the retina and regulate retinal gene expression. As retinoblastomas form within the retina, we hypothesized that sd-rxRNAs might also regulate gene expression in intraocular retinoblastoma cells. This SBIR award will enable us to test this hypothesis, possibly extending the application of sd-rxRNAs from ophthalmic diseases to the cancer setting."

RXi has been awarded approximately $300,000 to fund the collaborative project over six months.

Under this grant (R43CA165899), entitled "Development of sd-rxRNAs® as Therapy for Retinoblastoma and Other Malignancies", sd-rxRNA compounds will be developed to silence one or more targets critical to retinoblastoma cell growth and survival.

The sd-rxRNA compounds will be evaluated for efficacy in in vivo models of retinoblastoma by the Cobrinik lab.

"We are honored to have the opportunity to collaborate with the team at Memorial Sloan-Kettering, and are very pleased to have received financial support from the NCI to further the development of our novel RNAi compounds as potential therapeutics for ocular cancer," said Pamela Pavco, Chief Development Officer at RXi Pharmaceuticals.

Pavco continued, "The grant process is highly competitive, and this award serves to recognize and support the therapeutic potential of RXI's proprietary RNAi platform."

The Small Business Innovation Research (SBIR) program was created by the U.S. Congress to strengthen the role of small, innovative companies in federally supported research and development.

It is one of the largest sources of early-stage technology financing in the U.S. At the National Cancer Institute (NCI), these programs seek small business participation in the development and commercialization of technologies for the treatment and diagnosis of cancer.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Promising New Data on Self-delivering RNAi Compounds
RXi Pharmaceuticals Corporation have presented new data, on the company's proprietary self-delivering RNAi compounds developed to target Tyrosinase (TYR) and Collagenase (MMP1).
Wednesday, May 13, 2015
RXi Pharmaceuticals and Ethicor Announce the Signing of a Distribution Agreement
Agreement for RXI-109 in the European Union under the “Specials” Provision.
Tuesday, November 19, 2013
RXi Pharmaceuticals Appoints H. Paul Dorman and Curtis Lockshin, Ph.D. to Board of Directors
Mr. Dorman and Dr. Lockshin both bring significant industry experience that will be instrumental to supporting RXi’s growth and development initiatives.
Tuesday, April 23, 2013
RXi and miRagen Announce Formation of Research Collaboration in the Field of microRNAs
The collaboration will evaluate the potential utility of RXi’s rxRNA™ technology against specific miRNA targets of interest to mirage.
Tuesday, April 13, 2010
RXi Acquires Exclusive License to Potentially Paradigm-Changing RNAi Delivery Technology from Advirna LLC
The in-licensed technologies encompass four distinct approaches, with the primary focus on “self-delivery” of RNAi therapeutics.
Wednesday, July 29, 2009
RXi Pharmaceuticals Presented Breakthrough RNAi Delivery Technologies at the TIDES® 2009 Conference
Company’s CSO, Anastasia Khvorova, presented new pre-clinical data on therapeutically advanced RNAi compounds and delivery technologies.
Monday, May 25, 2009
RXi Gains Exclusive License to Oral Delivery of RNAi Therapeutics Technology from University of Massachusetts
Company plans to advance the discovery and development Oral rxRNA™ therapeutics for inflammatory diseases.
Wednesday, February 11, 2009
RXi Pharmaceuticals Licenses RNA Chemistry Technologies from TriLink Biotechnologies
The agreement includes rights to sublicense a patented RNA linker technology, a patent application on RNAi compositions and an undisclosed chemistry approach.
Tuesday, September 11, 2007
Scientific News
Liquid Biopsies: Utilization of Circulating Biomarkers for Minimally Invasive Diagnostics Development
Market Trends in Biofluid-based Liquid Biopsies: Deploying Circulating Biomarkers in the Clinic. Enal Razvi, Ph.D., Managing Director, Select Biosciences, Inc.
Watching a Tumour Grow in Real-Time
Researchers from the University of Freiburg have gained new insight into the phases of breast cancer growth.
Childhood Cancer Cells Drain Immune System’s Batteries
Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body’s immune cells, leaving them too physically drained to fight the disease.
Urine Proteins Point to Early-Stage Pancreatic Cancer
A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, researchers at the BCI have shown.
Researcher Discovers Trigger of Deadly Melanoma
New research sheds light on the precise trigger that causes melanoma cancer cells to transform from non-invasive cells to invasive killer agents, pinpointing the precise place in the process where "traveling" cancer turns lethal.
Self-Assembling, Biomimetic Membranes May Aid Water Filtration
A synthetic membrane that self assembles and is easily produced may lead to better gas separation, water purification, drug delivery and DNA recognition, according to an international team of researchers.
Error Correction Mechanism in Cell Division
Cell biologists have reported an advance in understanding the workings of an error correction mechanism that helps cells detect and correct mistakes in cell division early enough to prevent chromosome mis-segregation and aneuploidy, that is, having too many or too few chromosomes.
Researchers Resurrect Ancient Viruses
Researchers at Massachusetts Eye and Ear and Schepens Eye Research Institute have reconstructed an ancient virus that is highly effective at delivering gene therapies to the liver, muscle, and retina.
Cell Aging Slowed by Putting Brakes on Noisy Transcription
Experiments in yeast hint at ways to extend life of some human cells.
Crucial for Stem Cell Survival Protein Identified Using Editing Tool CRISPR
A team of University of Wisconsin-Madison engineers has identified a protein that is integral to the survival and self-renewal processes of human pluripotent stem cells (hPSC).
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!