Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

UK Researchers use Nanoscale Thermal Analysis Techniques to Improve Drug Delivery Systems

Published: Tuesday, December 04, 2012
Last Updated: Tuesday, December 04, 2012
Bookmark and Share
Anasys Instruments report on the use of their award-winning nanoscale characterization instrumentation to advance developments in the understanding of drug delivery systems.

The Drug Delivery & Materials Characterization Group at the University of East Anglia, UK, is internationally recognized for work involving the development of novel thermal, dielectric, rheological and microscopic techniques as analytical tools within the pharmaceutical sciences. There is particular emphasis on the study of the physical properties of drugs and dosage forms in relation to performance.

Post-doctoral researcher, Jonathan Moffat, is focused on delivery of poorly water soluble drugs and in particular characterization of delivery systems. His team creates solid dispersions using a variety of different methods which include hot melt extrusion, spray drying and spin coating. Solid dispersions are systems where one or more components are molecularly dispersed in a matrix/carrier. This idea means that if you are able to disperse your drug in a water soluble matrix such as a polymer, then you can improve the dissolution profile and improve the bioavailability of the drug.

The standard characterization methods for these systems include DSC, FTIR and PXRD. Their drawback is that they only provide bulk information. Dr Moffat comments: "As we are analyzing samples consisting of two or more components, we are interested in looking at the distribution, form and at the interface of components. These standard techniques cannot provide this information. Also, the surface of these systems is extremely important as this is the interface between the delivery system and the body. We chose the Anasys nano-TA system as it permits a thorough surface characterization. It is used alongside standard AFM & SEM imaging methods."

Dr Moffat continues: "Whilst these methods can provide high resolution images of the surface of our samples, they cannot provide information on the components within the system. Using nanoTA along with AFM allows the user to pick out features on the surface, interrogate them and subsequently determine the individual component via its transition temperature. As well as determining the component, it is also possible to determine its morphological properties as the transition temperature is sensitive to differences in these properties. This is something that can be difficult to determine with spectroscopic techniques. We also use Transition Temperature Microscopy, TTM, for our samples. This gives a systematic approach to determine the distribution and form of the components and also provides information on how well mixed the systems and whether there is any phase separation."

An example of this work was presented in a poster at the recent AAPS meeting held in Chicago. Dr Moffat's poster presented with co-author, Professor Duncan Craig from UEA, was entitled "Thermal Probe Methods for Nanoscale Characterization of Cyclosporin A Solid Dispersions Prepared by Hot Melt Extrusion."

Kevin Kjoller, Anasys' co-founder and Vice President, says "We're very excited about this new work by Dr Moffat and Professor Craig which potentially opens up a new market for our nanoscale thermal analysis technology." For more details, visit

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
Tolerant Immune System Increases Cancer Risk
Researchers have found that individuals with high immunoCRIT ratios may have an increased risk of developing certain cancers.
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
New Gene Therapy for Vision Loss From a Mitochondrial Disease
NIH-funded study shows success in targeting mitochondrial DNA in mice.
Predictive Model for Breast Cancer Progression
Biomedical engineers have demonstrated a proof-of-principle technique that could give women and their oncologists more personalized information to help them choose options for treating breast cancer.
Specific Variations in RNA Splicing Linked to Breast Cancer
Researchers have identified cellular changes that may play a role in converting normal breast cells into tumors. Targeting these changes could potentially lead to therapies for some forms of breast cancer.
Gene Expression: A Snapshot of Stem Cell Development
New genes found that regulate development of stem cells.
Assessing Cancer Patient Survival and Drug Sensitivity
RNA editing events another way to investigate biomarkers and therapy targets.
Editing Genes to Create HIV Killers
Seattle scientists have managed to genetically transform human cells in the lab from HIV targets to HIV killers, and the technique could have implications for cancer and other diseases.
Researchers Disguise Drugs As Platelets to Target Cancer
Researchers have for the first time developed a technique that coats anticancer drugs in membranes made from a patient’s own platelets.
A New Single-Molecule Tool to Observe Enzymes at Work
A team of scientists at the University of Washington and the biotechnology company Illumina have created an innovative tool to directly detect the delicate, single-molecule interactions between DNA and enzymatic proteins.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos