Corporate Banner
Satellite Banner
RNAi
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Polymer Nanoparticles Used as Drug Carriers Characterized Using Nanoparticle Tracking Analysis

Published: Tuesday, February 12, 2013
Last Updated: Tuesday, February 12, 2013
Bookmark and Share
NanoSight reports on how Nanoparticle Tracking Analysis, NTA, is used to help with the characterization of polymeric nanoparticles synthesized as drug carrier systems.

This work is being carried out at Saarland University, Saarbrücken in Germany by Dr Christian Ruge and his colleagues.

In the world of pharmaceutical sciences, a detailed and full characterization of particles synthesized as drug carrier systems is indispensable. The particle size is a crucial parameter to be monitored as this will affect the stability of formulations. It will also impact with respect to size-dependent effects in biological experiments, such as the uptake of drug systems by cells.

Nanoparticle Tracking Analysis is used as a complementary tool to a Malvern Zetasizer to characterize the nanoparticles prepared by Dr Christian Ruge, a research scientist in the Department of Biopharmaceutics and Pharmaceutical Technology in the group of Professor Claus-Michael Lehr. The particles are mainly polymer-based and typically in the size range from 100 nm to 400 nm. Especially when studying samples of moderate polydispersity (i.e. with a polydispersity index, PDI, of larger than 0.2), the group uses the NanoSight system to measure the preparations to identify particle populations which are not resolved by the Malvern system.

Talking of the benefits of using NTA rather than techniques such as scanning electron microscopy, SEM, or dynamic light scattering, DLS, Dr Ruge commented, "The fact that the system is performing particle-by-particle-based measurements is a huge advantage, especially in terms of its resolving power. The fact that the instrument gives a concentration value is very useful. I feel that "visualization" of the particles based on their scattered light gives more "insight" as to the sample and its behaviour. I personally find that it is more fun working with the NanoSight instrument compared to the Zetasizer. The interaction with the instrument and being able to visualize the individual particles makes it less of a "black box" instrument and more "interesting" for me as a scientist to use. Also, I have found that during demonstrations for students, the NanoSight appears to be more transparent and thus better suited for educational purposes."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,400+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Method Development to Estimate the Purity of Vesicle Preparations
Nanoparticle tracking analysis is used to estimate the purity of vesicle preparations at the Cardiff University School of Medicine.
Thursday, February 28, 2013
NanoSight Announce New Appointment
Leading UK scientist, Dr Andrew Shuttleworth, joins NanoSight board as Director of Diagnostic Sciences.
Tuesday, June 26, 2012
Duke University Uses NTA to Characterize "Nanoconstructs" for Biomedical Applications
NTA to characterize metal nanoparticle construct materials for use in biosensing, imaging and cancer therapy.
Friday, April 20, 2012
Scientific News
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
Shape Of Tumor May Affect Whether Cells Can Metastasize
Illinois researchers found that the shape of a tumor may play a role in how cancer cells become primed to spread.
MicroRNA Pathway Could Lead to New Avenues for Leukemia Treatment
Cancer researchers at the University of Cincinnati have found a particular signaling route in microRNA (miR-22) that could lead to targets for acute myeloid leukemia, the most common type of fast-growing cancer of the blood and bone marrow.
Analysis of Dog Genome will Provide Insight into Human Disease
An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies – according to a new study led by The Genome Analysis Centre (TGAC).
New Blood Test for The Earlier Diagnosis of Breast Cancer Spread
Researchers at University of Westminster have confirmed that a new blood test can detect if breast cancer has spread to other parts of the body.
First Gene Therapy Successful Against Human Aging
American woman gets biologically younger after gene therapies.
Targeting an ‘Undruggable’ Cancer Gene
RAS genes are mutated in more than 30 percent of human cancers and represent one of the most sought-after cancer targets for drug developers.
Altered Metabolism of Four Compounds Drives Glioblastoma Growth
Findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely.
Improving Engineered T-Cell Cancer Treatment
Purdue University researchers may have figured out a way to call off a cancer cell assassin that sometimes goes rogue and assign it a larger tumor-specific "hit list."
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,400+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!